ldl cholesterol

Below, you'll find up to date information, and "ldl cholesterol" reports and resources to help you with your awareness of Cholesterol. The Team at Awareness-Guide.com hope you find the answers you are looking for.

Treatment In High Cholesterol Cases
Groshan Fabiola

There are three types of cholesterol: total cholesterol, HDL cholesterol, which is the good and LDL cholesterol, which is bad. To treat actually means to lower the levels of LDL that one has in his/ her blood. This must be done because high almost always leads to heart related problems or even a heart attack. The higher is your risk of having heart problems, the lower LDL levels you must have.

There are two big and important ways that you might use to lower those levels. The main and at hand for everybody when is concerned is to change the way they live. This means that you should change the way you eat at first, in order to lower your LDL level. Plenty of physical exercise is also a must in treating cholesterol. If you are overweight, loosing those extra kilograms is re commanded if you want your level to go down. Using drugs is also another way to lower those levels. However, drugs alone can not do that. One must also change his/ her lifestyle as well if ant results in should be seen.

Doctors use as guideline for levels the number of mg/ dL that one has in his/ her blood. If your goal is to reduce your LDL levels to less than 100mg/ dl, than you definitely must start a diet. This should also be started in cases where your LDL levels is less than that number. If the level of bad in your blood is bigger than that figure, then drugs must also be taken together with the diet. However, there are cases when patients must also take drugs when their level is less than 100mg/ dl, because they have heart problems as well, or they suffer from diabetes. If the level of in your blood is bigger than 130, the diet must start right away. If there are no results in levels in the first three months of the diet, then drugs will be taken after, to better the treatment. There are also many different types of diets that one patient must use if his/ her goal is to lower the LDL level. If you are more at risk of developing a heart problem because of cholesterol, then you should be that more concerned how to lower the levels.

For greater resources on cholesterol please review www.cholesterol-info-guide.com/cholesterol-levels.htm or www.cholesterol-info-guide.com/low-cholesterol-recipe.htm

Additional Resources The Whole Truth About Green Tea Weight Loss Pills By Jason The countless health benefits of green tea has been well documented for many years, and the pills have now appeared on the market claiming to not only give you more energy and help you lose weight Read more...

Additional Resources One Day Miracle Diet By Oliver Turner One Day Miracle Diet – as dieticians put it – is a suitable diet program for gourmet buffs. This cholesterol lowering diet plan is quite simple – you diet for a day and eat full the next day and Read more...

We strive to provide only quality information, so if there is a specific topic related to cholesterol that you would like us to cover, please contact us at any time.

And again, thank you to those contributing daily to our Cholesterol Website, especially regarding "ldl cholesterol".

Impact of a normal or non-specific admission ECG on the treatment and early outcome of patients with myocardial infarction in Swiss hospitals between 2003 and 2008.
CONCLUSIONS: Despite less intensive treatment, AMI patients who presented with a normal/non-specific ECG developed cardiogenic shock less frequently during their hospitalisation and had a lower crude mortality rate compared to those with ECG changes on admission. Nevertheless, reinfarctions and cerebrovascular events occurred evenly in all AMI patients, regardless of their admission ECG. PMID: 20799102 [PubMed - in process] (Source: Swiss Medical Weekly)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prevalence of high serum uric acid is increased in ambulatory subjects with hyperglycemia and dyslipidemia
CONCLUSION: These results show the association between serum levels of uric acid and metabolic syndrome profile, which corroborates to similar results found in other populations worldwide.INTRODUÇÃO: O ácido úrico sérico tem sido considerado um marcador ou componente das alterações clínicas e laboratoriais da síndrome metabólica. OBJETIVO: Avaliar a associação entre o ácido úrico sérico (AU) e o perfil laboratorial composto de glicemia de jejum &gt; 100 mg/dl, triglicerídeos &gt; 150 mg/dl e colesterol da lipoproteína de alta densidade (HDL-C) < 50 mg/dl nas mulheres e < 40 mg/dl nos homens. MÉTODO: Em estudo de corte transversal, amostras de sangue de 4.328 pacientes ambulatoriais não selecionados com idade variando de 20 a 102 anos foram examinadas. RESULTADOS: A media...
Statins can cut RA risk
Cholesterol-lowering statin drugs may reduce the risk of developing rheumatoid arthritis, a large study has shown (Source: Pharmacy Europe)
Resolution of Statin-Induced Myalgias by Correcting Vitamin D Deficiency
Resolution of statin-induced myalgias with vitamin D supplementation may allow the use of powerful statin therapy in cases where it would not otherwise be tolerated. Southern Medical Journal (Source: Medscape Cardiology Headlines)
Cholesterol-Lowering Drugs May Cut RA Risk
People who take cholesterol-lowering statin drugs to reduce heart disease risk may also be cutting their risk for developing the painful inflammatory joint disease rheumatoid arthritis. (Source: WebMD Health)
Statins May Guard Against Rheumatoid Arthritis
Study showed only an association between the two, expert notes (Source: The Doctors Lounge - Cardiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Statins linked to lower rheumatoid arthritis risk
LONDON (Reuters) - Israeli scientists have found a significant link between taking cholesterol-lowering statin drugs like Lipitor or Crestor and a reduced risk of developing rheumatoid arthritis. (Source: Reuters: Health)
Cholesterol drug may block arthritis
Conclusion This large cohort study has established a link between longer use of statins and a reduced risk of rheumatoid arthritis and osteoarthritis. It should be noted that the study compared the incidence of rheumatoid arthritis in people taking different amounts of statins, but did not assess arthritis risk in people who did not use statins. Therefore, this study cannot tell us whether taking the drugs is better at preventing rheumatoid arthritis than taking no statins at all. The study?s design had a number of potential limitations: It is not clear whether the study took into account all possible confounding factors (those linked to the exposure and outcome). One important potential confounder is the cholesterol-lowering action of statin drugs. Lower rates of rheumatoid arthrit...
Study links cholesterol, nonstick coating chemical
CHICAGO (Reuters) - Chemicals used to make non-stick coatings on cookware and to waterproof fabrics may raise levels of cholesterol in children, U.S. researchers said on Monday. (Source: Reuters: Health)
Associatiion Between Regular Statin Use And A Reduced Risk Of Developing Rheumatoid Arthritis
There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis. These are the findings of a study by Gabriel Chodick and colleagues, published in this week's PLoS Medicine. The researchers conducted a retrospective cohort study among the 1.8-million members of Maccabi Healthcare Services (a health maintenance organization [HMO]) in Israel to identify adults who regularly took statins and did not have rheumatoid arthritis... (Source: Health News from Medical News Today)
Explaining An Important Genetic Cardiovascular Risk Factor
New findings reported in the September issue of Cell Metabolism, a Cell Press publication, appear to explain why people who carry specific and common versions of a single gene are more likely to have high cholesterol and to suffer a heart attack. Studies in mice show that the gene, known as sortilin (SORT1), controls the release of LDL (a.k.a. "bad") cholesterol from the liver into the bloodstream. The findings suggest that SORT1 may be a good target for new cholesterol-lowering drugs, according to the researchers... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
In conclusion, M. tamulus gangeticus can be considered a lethal scorpion species. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Regular statin use is associated with a reduced risk of developing rheumatoid arthritis
There is an association between taking statins (lipid lowering drugs), and reduced risk of developing the chronic inflammatory disease, rheumatoid arthritis. (Source: ScienceDaily Headlines)
An important genetic cardiovascular risk factor explained
New findings appear to explain why people who carry specific and common versions of a single gene are more likely to have high cholesterol and to suffer a heart attack. Studies in mice show that the gene, known as sortilin, controls the release of LDL (a.k.a. "bad") cholesterol from the liver into the bloodstream. (Source: ScienceDaily Headlines)
P2.30 Oral fat loading study ? does specific hyperlipemia exist in myotonic dystrophy type 1?
Conclusion: Only FFA showed significant difference in the loading test between MD1 and controls. The lower level of FFA in MD1 could reflect effects of insulin itself. Our results suggested that MD1 had no specific postprandial hyperlipemia. Abnormality of lipid metabolism in MD1 should be clinically treated as secondary hyperlipemia. (Source: Neuromuscular Disorders)
P1.32 A genetic variant within caveolin-3 protects against statin-induced myopathy
Myopathy is a frequent and potentially life-threatening complication of statin therapy. We hypothesized that there is genetic susceptibility to statin-induced myopathy could be associated with skeletal muscle-related genes. We enrolled a cohort of 400 patients, 250 with muscular symptoms and 150 matched asymptomatic individuals, after due approval. We collected all demographic and laboratory data, including genomic DNA. Muscular symptoms associated with statin intake were defined as muscle pain and/or muscle cramps and/or elevated CK. Laboratory and clinical data were available from all patients, including CK, lipids and liver enzymes. We genotyped single-nucleotide polymorphisms (SNPs) in Caveolin-3, a gene associated with ?painful myopathy?. (Source: Neuromuscular Disorders)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Patients on statins to lower cholesterol 'at less risk of arthritis' study finds
Drugs taken by millions of patients to cut cholesterol levels may also keep arthritis at bay. (Source: the Mail online | Health)
Aripiprazole: Hypertriglyceridaemia and first report of hypercholesterolaemia: case report
(Source: Reactions)
Statin-induced myopathy: minimize the risk and manage according to symptoms and creatine kinase levels
(Source: Drugs)
Non-stick cookware linked to cholesterol
MORGANTOWN, W.Va., Sept. 8 (UPI) -- Chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated cholesterol levels, U.S. researchers say. United States - Non-stick surface - Cholesterol - Cookware and bakeware - Health (Source: Health News - UPI.com)
Positive US total and LDL cholesterol trends countered by triglyceride rises
There has been a trend toward an overall decrease in total cholesterol and low-density lipoprotein cholesterol levels in the USA in recent years, say researchers who attribute this in part to the increased use of lipid-lowering medication. (Source: MedWire News - Lipidology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Statins 'may cut arthritis risk'
Taking statins may reduce the risk of developing rheumatoid arthritis, a study suggests. (Source: BBC News | Health | UK Edition)
High Cholesterol Linked to Cookware Chemicals
Exposure to chemicals used in the manufacture of nonstick cookware and waterproof and stain-resistant products could be raising cholesterol levels in children, a new study suggests. (Source: WebMD Health)
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Authors: Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A Recent genome-wide association studies (GWAS) have revealed strong association of hypercholesterolemia and myocardial infarction with SNPs on human chromosome 1p13.3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100. It interacts with apoB100 in the Golgi and facilitates the formation and hepatic export of apoB100-containing lipoproteins, thereby regulating plasma low-density lipoprotein (LDL) cholesterol. Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and athero...
Population-based cohort study shows persistence with statins and delays onset of rheumatoid arthritis
Source: PLoS Medicine Area: News According to research published in PLoS Medicine, taking statins may reduce the risk of rheumatoid arthritis (RA). &nbsp; The retrospective cohort study explored whether persistent use of statins is associated with the onset of RA, using a computerised medical database of a large health organisation in Israel, from which diagnosed RA cases among adults who began statin therapy between 1998 and 2007 were evaluated. Persistence with statins was assessed by calculating the mean proportion of follow-up days covered (PDC) with statins for every study participant. To assess the possible effects of healthy user bias, the risk of osteoarthritis (OA), which is unlikely to be affected by use of statins, was also assessed. A total of 211,627 and 193,770 individua...
High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile
Authors: R Jorde, Y Figenschau, M Hutchinson, N Emaus & G Grimnes (Source: European Journal of Clinical Nutrition)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
A multifactorial analysis of obesity as CVD risk factor: use of neural network based methods in a nutrigenetics context
Conclusions: The ANN based methods revealed factors that interactively contribute to obesity trait and provided predictive models with a promising generalization ability. In general, results showed that ANNs and their hybrids can provide useful tools for the study of complex traits in the context of nutrigenetics. (Source: BMC Bioinformatics - Latest articles)
3 Ways to Reduce the Health Risks of Nonstick Chemical PFOA
The chemical in Teflon is linked to high cholesterol in kids. (Source: U.S. News - Health)
FDA, CDC Warn of Misuse of Fingerstick, Point-of-Care Blood Testing Devices
The FDA has issued a safety alert about the potential for bloodborne infection transmission associated with misuse of fingerstick devices and point-of-care blood testing devices, including blood glucose meters and cholesterol testing devices. At the same time, the CDC has updated its safety information for clinicians related to this topic. (Source: AAFP Health of the Public)
Common Meds Lower the Risk That First MI Will Be a STEMI
Patients who take common medications -- aspirin, beta-blockers, ACE inhibitors, and statins - are at lower risk for ST-segment elevation in a first myocardial infarction (STEMI), Swedish researchers report in the August 9/23 Archives of Internal Medicine. Reuters Health Information (Source: Medscape Medical News Headlines)
Can you survive your personality?
You've undoubtedly heard the term "Type A" personality to refer to someone who is hard-driving, competitive, and impatient. What you might not realize is that the "A" in Type A doesn't really stand for anything in particular. Though, if you are a true "Type A," you might think it's good to be called anything with an A in it. It certainly seems better than "Type A minus."The story behind the term's discovery is revealing in and of itself. Back in the late 1960s, cardiologists Meyer Friedman and Ray Rosenman noticed that the chairs in their waiting room showed uneven patterns of wear. All of them were fraying at the edges of the seats and armrests. It dawned on the good doctors (actually their receptionist) that perhaps their patients seeking treatment for heart disease were anything but "pa...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis
Conclusion Contrast-enhanced ultrasound is effective for in vivo detection of vasa vasorum in atherosclerotic plaques in the RFH swine model. After stimulation of atherosclerosis, contrast-enhanced ultrasound demonstrated a significantly increased IMT and significantly increased density of the vasa vasorum network in the developing atherosclerotic plaque, which was validated by histology. (Source: European Journal of Echocardiography)
Non-stick chemicals linked to high cholesterol in kids
The chemicals contained in non-stick cookware and waterproof fabrics may be linked to elevated levels of cholesterol in children and teenagers, new research shows. (Source: CBC | Health)
Non-stick chemical linked to raised cholesterol
The chemicals that are used to make non-stick cookware, microwave popcorn bags and stain- and water-repellent fabric may also raise cholesterol levels in children, a new study suggests. (Source: CTV Health)
Compounds in Nonstick Cookware May Be Associated with Elevated Cholesterol in Children and Teens
September 6, 2010 (EurekAlert) - Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. read more (Source: Diabetes News from dLife.com)
Non-stick Cookware And Waterproof Fabrics Linked To Higher Cholesterol Levels In Kids
Chemicals used in the production of non-stick cookware and waterproof fabrics, known as perfluoroalkyl acids, can get into children's blood and raise their LDL cholesterol levels ("bad cholesterol" levels), says an article published in Archives of Pediatrics & Adolescent Medicine. Examples of perfluoroalkyl acids include PFOA (perfluorooctanoic acid) and PFOS (perfluorooctanesulfonate). LDL stands for low density lipoprotein, known as "bad cholesterol". HDL stands for high density lipoprotein, known as "good cholesterol" (see further down for an explanation on cholesterol)... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Reduced High-Density Lipoprotein Level is Linked to Worse Ankle Brachial Index and Peak Oxygen Uptake in Postmenopausal Women With Peripheral Arterial Disease
Women with peripheral arterial disease (PAD) have more limited physical function than men but the mechanisms involved are not clear. We determined whether alterations in lipid components, such as decreased high-density lipoprotein cholesterol (HDL-C), are associated with worsening intermittent claudication (IC) in postmenopausal women with PAD. Our cross-sectional cohort study included 69 postmenopausal women with IC (Fontaine stage II). A treadmill test was used to measure initial claudication distance (ICD), absolute claudication distance (ACD), peak oxygen uptake, and ankle systolic blood pressure. High-density lipoprotein cholesterol correlated with ankle brachial index ([ABI]; R = .29, P = .019). No other lipid profile components were associated with exercise performance and hemodynam...
Efficacy of Short-Term High-Dose Atorvastatin for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography
Contrast-induced nephropathy (CIN) is associated with increased morbidity, extended hospital stay, and higher costs. We compared an atorvastatin plus N-acetylcysteine (NAC) regimen with NAC alone in patients undergoing coronary angiography. A total of 130 patients (mean age 54 &plusmn; 10; 77 men) undergoing coronary angiography were studied. Seven CIN cases occurred in the NAC group and 2 in the atorvastatin + NAC group; this difference was not significant. Baseline mean creatinine and estimated glomerular filtration rate (eGFR) were similar between the 2 groups, whereas after the procedure there was a significant creatinine decrease and eGFR increase in the atorvastatin + NAC group. Change in creatinine (baseline creatinine&mdash;creatinine after the procedure) was also significantly hig...
Routine statin use before invasive procedures proposed
US researchers have called for the routine use of statins before invasive procedures to be considered, after their meta-analysis showed it could reduce the subsequent risk of myocardial infarction. (Source: MedWire News - Lipidology)
Non-stick frying pans 'could raise bad cholesterol in children'
Exposure to chemicals used in non-stick frying pans could raise the levels of cholesterol in children, U.S researchers have warned. (Source: the Mail online | Health)
Size at birth and lipoprotein concentrations in adulthood: two prospective studies in Latin American cities
Conclusion The results suggest that those who were of low birth weight and are obese are more likely to have high cholesterol and LDL concentrations. Thus preventing obesity may be especially rewarding in subjects with a low birth weight. (Source: Journal of Epidemiology and Community Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a new article. (Source: ScienceDaily Headlines)
Hormone in Hair May Reveal Heart Risk
Title: Hormone in Hair May Reveal Heart RiskCategory: Health NewsCreated: 9/7/2010 10:36:00 AMLast Editorial Review: 9/7/2010 10:36:35 AM (Source: MedicineNet Cholesterol General)
Winter Sports Tourists at Higher Risk of Heart Attack
Title: Winter Sports Tourists at Higher Risk of Heart AttackCategory: Health NewsCreated: 9/5/2010 10:10:00 AMLast Editorial Review: 9/7/2010 (Source: MedicineNet Cholesterol General)
Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
Title: Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in TeensCategory: Health NewsCreated: 9/6/2010 4:10:00 PMLast Editorial Review: 9/7/2010 (Source: MedicineNet Cholesterol General)
Nonstick Cookware May Raise Kids' Cholesterol (CME/CE)
(MedPage Today) -- Kids who eat food cooked in nonstick pots and pans may have higher levels of LDL cholesterol, a large cross-sectional study found. (Source: MedPage Today Cardiovascular)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Non-stick Cookware May be Associated with Elevated Cholesterol
Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens. (Source: Disabled World)
Non-stick pan 'cholesterol link'
Scientists are concerned that exposure to chemicals used in non-stick frying pans could raise cholesterol levels in children after finding a link. (Source: BBC News | Health | UK Edition)
'That time of the month' might be a factor in women's cholesterol levels
Women who have their cholesterol checked only to be taken aback at an oddly high level of HDL or LDL might want to check the calendar. Was the appointment at the latter end of the menstrual cycle? The beginning? Their estrogen level at the time might be a... (Source: OrlandoSentinel: Medical Research)
Licensing process for top selling diabetes drug under fire
Doctors should demand more rigorous proof of long term risks and benefits for diabetes drugsRelated items from OnMedicaAntihypertensive drugs vary in heart attack riskRisk/benefit balance of alteplase shifts quicklyCare homes drug error rate raises concernsFake medicine warning hits cinemasBenefits of statins 'still outweigh risks' (Source: OnMedica Latest News)
'That time of the month' might play cholesterol role
Women who have their cholesterol checked only to be taken aback at an oddly high level of HDL or LDL might want to check the calendar. Was the appointment at the latter end of the menstrual cycle? The beginning? Their estrogen level at the time might be a... (Source: OrlandoSentinel: Medical Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Study links cholesterol, nonstick coating chemical
Chemicals used to make non-stick coatings on cookware and to waterproof fabrics may raise levels of cholesterol in children, U.S. researchers said Monday. Children in a study with the highest levels of these compounds in their blood had measurably higher... (Source: OrlandoSentinel: Medical Research)
Associations of Fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy
Conclusions: The results of this cross-sectional study suggest that lower fetuin-A levels are associated with macrovascular late complications in high-risk type 2 diabetes patients while there are no associations of fetuin-A with metabolic status or microvascular complications. (Source: Cardiovascular Diabetology)
Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study
Conclusion: This study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels. (Source: Lipids in Health and Disease)
Combination of Fenofibrate with Non-Statin Drug Regimens.
Conclusions: For patients who cannot tolerate statins there are useful combinations of fenofibrate with other drugs affecting lipid metabolism. These combinations improve several metabolic parameters, but more trials should be carried out to reach more robust conclusions about their effects on cardiovascular events. PMID: 20819059 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Persistence with Statins and Onset of Rheumatoid Arthritis: A Population-Based Cohort Study
In a retrospective cohort study, Gabriel Chodick and colleagues find a significant association between persistence with statin therapy and reduced risk of developing rheumatoid arthritis, but only a modest decrease in risk of osteoarthritis. (Source: PLoS Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
Long-term effect of exposure to PFOAs, PFOS compounds still unknown, researchers say (Source: The Doctors Lounge - Cardiology)
Study links cholesterol and nonstick coating chemical
CHICAGO (Reuters) - Chemicals used to make non-stick coatings on cookware and to waterproof fabrics may raise levels of cholesterol in children, U.S. researchers said on Monday. (Source: Reuters: Health)
Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
Long-term effect of exposure to PFOAs, PFOS compounds still unknown, researchers say Source: HealthDay Related MedlinePlus Pages: Cholesterol, Environmental Health, Teen Health (Source: MedlinePlus Health News)
Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome [Article]
Conclusions&nbsp; Biomedical anomalies seen in adults with CFS/ME&mdash;increased oxidative stress and increased white blood cell apoptosis&mdash;can also be observed in children with clinically diagnosed CFS/ME compared with matched controls. Unlike in their adult counterparts, however, arterial stiffness remained within the reference range in these pediatric patients. (Source: Archives of Pediatrics)
Perfluorooctanoic Acid, Perfluorooctanesulfonate, and Serum Lipids in Children and Adolescents: Results From the C8 Health Project [Article]
Conclusion&nbsp; Although the epidemiologic and cross-sectional natures of this study limit causal inferences, the consistently observed associations between increasing PFOA and PFOS and elevated total cholesterol and LDL-C levels warrant further study. (Source: Archives of Pediatrics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The influence of atorvastatin on tendon healing: an experimental study on rabbits.
Authors: Esenkaya I, Sakarya B, Unay K, Elmali N, Aydin NE Hyperlipidemia is a major risk factor for coronary heart disease. The most commonly used antihyperlipidemic drugs are 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), of which atorvastatin is one of the most widely used. Little is known about the relationship between tendinopathy and HMG CoA reductase inhibitors (statins) or the effects of atorvastatin use on tendon healing following surgical repair of tendon rupture. We hypothesized that atorvastatin negatively affects this healing process.The Achilles tendons of 16 New Zealand rabbits were ruptured surgically and repaired with sutures. Eight of the rabbits were given oral atorvastatin. The other 8 served as a surgical control group. Six weeks po...
Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease
Conclusions Portal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease. (Source: Journal of Clinical Pathology)
Almost Half Of All Americans Use Prescription Drugs Each Month
Nearly half of all Americans used at least one prescription drug per month in 2008, according to a study by the Centers for Disease Control and Prevention, Bloomberg reports. That's a 10 percent increase over the preceding decade. Over that time, yearly spending by Americans on drugs doubled to $234 billion. "The two biggest-sellers last year were Pfizer Inc.'s Lipitor for high cholesterol and Bristol-Myers Squibb Co.'s clot-buster, Plavix. The rise of such medicines may continue as insurers add as many as 32 million customers through the U.S... (Source: Health News from Medical News Today)
Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
(JAMA and Archives Journals) Children and teens with higher blood levels of chemicals used in the production of non-stick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. (Source: EurekAlert! - Medicine and Health)
Compounds in nonstick cookware may be associated with elevated cholesterol in children and teens
(JAMA and Archives Journals) Children and teens with higher blood levels of chemicals used in the production of nonstick cookware and waterproof fabrics appear more likely to have elevated total and LDL cholesterol levels, according to a report in the September issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
Common chemicals found in everything from non-stick cookware to grease-resistant food packaging appear to be associated with increases in cholesterol levels in adolescents, a new study suggests. People are exposed to these chemicals -- known as perfluoroalkyl acids (PFAAs) -- in dust, drinking water, non-stain carpets, waterproof fabrics, microwave popcorn bags and a host of other household products. (Source: RWJF News Digest - Public Health)
Study suggests use of some common medicines may alter serum PSA levels
Source: J Clin Oncol Area: News According to the results of a study published in the Journal of Clinical Oncology, use of NSAIDs, statins, and thiazide diuretics may result in clinically relevant reductions in levels of prostate-specific antigen (PSA). &nbsp; The authors note that previous research has suggested use of some common medicines may alter PSA levels. They investigated the impact of individual and combinations of common medications on PSA in a cohort of men (aged 40 years and above) without prostate cancer who participated in the 2003-2004 and 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES) in the US (n=1,864).&nbsp; Those with recent prostate manipulation, prostatitis, and those on hormone therapy were excluded.&nbsp; Use of the ten most c...
Meta-analysis: Pre-procedural statin therapy
Source: J Am Coll Cardiol Area: News According to the findings of this meta-analysis, the initiation of statins prior to invasive procedures may reduce the risk of post-procedural myocardial infarction, and the risk of atrial fibrillation (AF) following coronary artery bypass grafting (CABG). &nbsp; The authors note that invasive procedures carry a risk of adverse cardiovascular events; when these occur they are associated with poor clinical outcomes.&nbsp; Although statins have proven to be beneficial when started during an acute coronary syndrome (ACS), most trials started treatment after percutaneous coronary intervention (PCI) was undertaken.&nbsp; The purpose of this meta-analysis was to evaluate whether statins administered before invasive procedures would reduce adverse cardiov...
Changes in Biochemical Parameters Related to Lipid Metabolism Following Titanium Treatment in Rat
In this study, the effects of titanium on biochemical parameters related to lipid metabolism were investigated. Male Wistar rats were treated with different doses of titanium for a period of up to 60 days. Blood samples were then collected for analysis. Lipid related parameters in plasma were measured by standard methods. It was shown that titanium reduced plasma VLDL and triglycerides concentrations but increase in LDL-C and cholesterol levels were seen in all experimental groups. Titanium also showed to inhibit lipoprotein lipase activity. The finding that titanium increases LDL&nbsp; and cholesterol concentrations should be considered seriously, especially in people exposing to titanium compounds for a long period. (Source: Iranian Journal of Pharmacology and Therapeutics (IJPT))
Commonly used medications may reduce PSA levels
Men using commonly prescribed medications?nonsteroidal anti-inflammatory drugs, statins, and thiazide diuretics?appear to experience reduced PSA levels by clinically significant amounts, researchers from Stanford University, Stanford, CA recently reported. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Dairy products and plasma cholesterol levels.
Authors: Ohlsson L Cholesterol synthesized in the body or ingested is an essential lipid component for human survival from our earliest life. Newborns ingest about 3-4 times the amount per body weight through mother's milk compared to the dietary intake of adults. A birth level of 1.7 mmol/L plasma total cholesterol will increase to 4-4.5 mmol/L during the nursing period and continue to increase from adulthood around 40% throughout life. Coronary artery disease and other metabolic disorders are strongly associated with low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol as well as triacylglycerol concentration. Milk fat contains a broad range of fatty acids and some have a negative impact on the cholesterol rich lipoproteins. The saturated fatty acids (SFAs), s...
Fenofibrate added to pravastatin could help control mixed hyperlipidemia
Adding 160 mg fenofibrate daily to 40 mg pravastatin can significantly improve the lipid profile of high-risk patients whose mixed hyperlipidemia is not controlled by the statin alone, trial findings suggest. (Source: MedWire News - Lipidology)
Colors of Chemistry - September 2010
Mounting evidence suggests that virgin olive oil consumption may mitigate the risk of heart disease by reducing low-density lipoprotein (LDL) cholesterol in the blood stream. This link is thought to be partly due to the antioxidant properties of phenolic substances found along with chlorophyll in virgin olive oil. (Source: CAS - Chemical Abstracts Service)
Americans drowning in prescription drugs
(NaturalNews) Nearly half of all Americans now use prescription drugs on a regular basis according to a CDC report that was just released (1). Nearly a third of Americans use two or more drugs, and more than one in ten use five or more prescription drugs regularly.The report also revealed that one in five children are being regularly given prescription drugs, and nine out of ten seniors are on drugs.All these drugs came at a cost of over $234 billion in 2008. The most commonly-used drugs were:&bull; Statin drugs for older people &bull; Asthma drugs for children &bull; Antidepressants for middle-aged people &bull; Amphetamine stimulants for childrenAmerica has become a nation of druggies. The seniors are being drugged for nearly every symptom a doctor can find, children are being doped up w...
Bisphosphonates may double cancer risk
Long-term oral bisphosphonates may double risk of oesophageal cancerRelated items from OnMedicaBisphosphonate use does not raise cancer riskMortality higher if using paroxetine and tamoxifenNew osteoporosis risk scores highly effectiveFalls prevention services are not evidence-basedBenefits of statins 'still outweigh risks' (Source: OnMedica Latest News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
An improved anion-exchange high-performance liquid chromatography method for measuring oxidized form of LDLs in human plasma
Conclusion Here, we developed a convenient HPLC method and identified LDL-3 as oxidized LDL fractions, although ox-LDLs were present in LDL-2 fraction, albeit lesser concentrations than in LDL-3 subfraction. Measuring ox-LDL levels in human plasma by this method may be useful to evaluate atherosclerotic disorders. (Source: Annals of Clinical Biochemistry)
A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100
We present a 15-year-old girl with untreated total cholesterol levels of 8.8 mmol/L who was heterozygous for both the LDLR p.Leu479Pro and APOB p.Arg3527Gln mutation. Cascade testing confirmed the paternal origin of the LDLR mutation and revealed a maternal diagnosis of FDB. This case provides further evidence that the combined effect of an LDLR and an APOB mutation give rise to a phenotype more severe than either mutation alone and is more severe than homozygous FDB, but less severe than homozygous FH. It also highlights the need to consider the presence of additional mutations in families where relatives have varying phenotypes. (Source: Annals of Clinical Biochemistry)
Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma
Conclusion HTGL plays a major role in HDL metabolism, but not RLP metabolism. These findings suggest that ANGPTL3 is strongly associated with the inhibition of HTGL activity and regulates HDL metabolism, but not associated with the inhibition of LPL activity for the metabolism of RLPs in human plasma. (Source: Annals of Clinical Biochemistry)
Supersize Nutrition With Superfoods
Superfoods won?t give you x-ray vision or invisibility powers, but they may have the power to help fight cancer, heart disease, obesity, and even bad moods. Duke oncology nutritionist Heidi Scarsella, RD, CSO, LDN, says that while there is no dictionary definition of a superfood, the term refers to foods that are nutrient-dense for their serving size. ?A nutrient-dense food provides substantial amounts of vitamins and minerals and relatively few calories,? she explains. Some examples include brightly colored fruits and vegetables, whole grains, low-fat and fat-free milk, cheese, and yogurt; and lean meat, poultry, fish, eggs, beans, and nuts. Standout Superfoods Click through the slideshow to see some of Scarsella?s favorite superfoods and learn what nutritional benefits you can re...
CS Controls Proteolytic Activity of Cell-bound MMP-7 [Lipids]
In this study, we investigated the role of CS in the MMP-7-catalyzed degradation of protein components of ECM. We found that the degradation of laminin-332 (laminin-5) catalyzed by MMP-7 was accelerated dramatically in the presence of CS, whereas the sulfated lipid inhibited the degradation of casein catalyzed by the protease. The MMP-7-catalyzed degradation of fibronectin was partially inhibited in the presence of low concentrations of CS, whereas it was accelerated significantly at high concentrations of the lipid. Therefore, it is likely that CS alters the substrate preference of MMP-7. We also found that the proteins of which MMP-7-catalyzed degradation were accelerated by CS also had affinities for CS, suggesting that CS facilitates the proteolyses by cross-linking MMP-7 to its substr...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Binding of Thapsigargin and Analogs in SERCA [Molecular Biophysics]
We present x-ray crystallographic and intrinsic fluorescence data to show how Tg and chemical analogs of the compound with modified or removed side chains bind to isolated SERCA 1a membranes. This occurs by uptake via the membrane lipid followed by insertion into a resident intramembranous binding site with few adaptative changes. Our binding data indicate that a balanced hydrophobicity and accurate positioning of the side chains, provided by the central guaianolide ring structure, defines a pharmacophore of Tg that governs both high affinity and access to the protein-binding site. Tg analogs substituted with long linkers at O-8 extend from the binding site between transmembrane segments to the putative N-terminal Ca2+ entry pathway. The long chain analogs provide a rational basis for the ...
Statins switching 'may increase patients' cardiovascular risk'
Switching patients from branded to generic statins may increase their risk of cardiovascular events, according to new research. (Source: Pulse)
Prescription Drug Use on the Rise in U.S.
Title: Prescription Drug Use on the Rise in U.S.Category: Health NewsCreated: 9/3/2010 9:03:00 AMLast Editorial Review: 9/3/2010 9:03:48 AM (Source: MedicineNet Cholesterol General)
Health Tip: If You Have Cirrhosis
Title: Health Tip: If You Have CirrhosisCategory: Health NewsCreated: 9/2/2010 10:10:00 AMLast Editorial Review: 9/3/2010 (Source: MedicineNet Cholesterol General)
Vets With Stress Disorder More Likely to Develop Dementia
Title: Vets With Stress Disorder More Likely to Develop DementiaCategory: Health NewsCreated: 9/2/2010 10:10:00 AMLast Editorial Review: 9/3/2010 (Source: MedicineNet Cholesterol General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Should Statin Therapy Be Allocated on the Basis of Global Risk or on the Basis of Randomized Trial Evidence?
In conclusion, the authors propose an alternative approach for incorporating more recent randomized trial data into future statin allocation algorithms and treatment guidelines. (Source: The American Journal of Cardiology)
Direct LDL-cholesterol assay may suit fasting and nonfasting serum samples
Japanese research suggests that epidemiological studies can assess levels of low-density lipoprotein cholesterol using direct homogenous assay in both fasting and nonfasting serum samples. (Source: MedWire News - Lipidology)
Tight blood pressure control can save kidneys
Kidney function preserved in black people with proteinurea by aggressive BP loweringRelated items from OnMedicaBenefits of statins 'still outweigh risks'Bowel disease raises risk of blood clots threefoldRisk/benefit balance of alteplase shifts quicklyConsider statins for patients at risk of clotHigh salt intake strongly linked to stroke and CVD (Source: OnMedica Latest News)
Ezetimibe/Simvastatin Combo Lowers LDL in Type 2 Diabetes
For patients with type 2 diabetes who are not meeting recommended low-density lipoprotein cholesterol goals, adding ezetimibe to simvastatin treatment significantly increases the likelihood of reaching a low-density lipoprotein cholesterol level below 70 mg/dL, according to a study published in the September issue of Diabetes Care. (Source: Modern Medicine)
The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse
In conclusion, in the diabetic Apo-E&ndash;/&ndash; mouse, rosuvastatin confers renal benefits that are independent of lipid lowering and equivalent or greater to those observed with candesartan. The combination treatment is not superior to monotherapies. (Source: AJP: Renal Physiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Prescription Drug Use Rising in U.S., CDC Reports
Statins, asthma meds, antidepressants and stimulants top the list (Source: The Doctors Lounge - Cardiology)
Prescription Drug Use Rising in U.S.
Statins, asthma meds, antidepressants and stimulants top the list Source: HealthDay Related MedlinePlus Pages: Health Statistics, Medicines (Source: MedlinePlus Health News)
September Is National Cholesterol Education Month
Source: Centers for Disease Control and Prevention Related MedlinePlus Page: Cholesterol (Source: MedlinePlus Health News)
Better Than Coffee
Dear Health Conscious Reader, People love this stuff, so in case you missed this? I have something that will electrify you? It?s even better than coffee. When I was hiking through the Amazon Rain Forest last year, I had a first-hand experience with a remarkable healing herb. This rain forest herb gives you lasting energy ? without the crash. Sacred to the nearby Guarani tribe, it was literally a gift  the gods. According to tribal folklore, the Indians of the Amazon River Basin have been using it to prevent fatigue and increase physical endurance since before recorded history. I took it in the early morning before we hit the trail. After 18 hours through the jungles of Peru my mind was crystal clear and I had no feeling of fatigue. Looking back, I had covered 15 miles of rugged te...
Importance of a balanced diet on the physical fitness level of schoolchildren aged 6-12
This article explores the integrated effect of nine nutrients on an individual&rsquo;s physical fitness level. Two-day dietary records and physical fitness assessments were collected in three primary schools. Cluster analysis allowed compliance with nutrient recommendations to be compared among groups of primary school students with different characteristics. Two clusters were identified statistically. Cluster B, which comprised more schoolchildren at the &lsquo;Good&rsquo; and &lsquo;Pass&rsquo; levels and fewer at the &lsquo;Excellent&rsquo; level, had significantly more participants who met the guidelines for total fat, saturated fat, sodium and cholesterol, compared with Cluster A. This finding reveals the benefits of a balanced diet, with physical fitness level as the outcome measure....<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Rosuvastatin-Induced Thrombocytopenia
Since thrombocytopenia can have many different causes, statin therapy might easily have been overlooked as the precipitating factor in this patient taking Rosuvastatin. Southern Medical Journal (Source: Medscape Today Headlines)
Weight Loss Pill Meridia Raises Heart Attack, Stroke Risks
Title: Weight Loss Pill Meridia Raises Heart Attack, Stroke RisksCategory: Health NewsCreated: 9/2/2010 11:01:00 AMLast Editorial Review: 9/2/2010 11:01:05 AM (Source: MedicineNet Cholesterol General)
Overactive Blood Platelets May Play Role in Lupus
Title: Overactive Blood Platelets May Play Role in LupusCategory: Health NewsCreated: 9/1/2010 4:10:00 PMLast Editorial Review: 9/2/2010 (Source: MedicineNet Cholesterol General)
Double-Dose Plavix Benefits Certain Patients, Study Finds
Title: Double-Dose Plavix Benefits Certain Patients, Study FindsCategory: Health NewsCreated: 9/1/2010 6:10:00 PMLast Editorial Review: 9/2/2010 (Source: MedicineNet Cholesterol General)
Effects of Tai Chi on adiponectin and glucose homeostasis in individuals with cardiovascular risk factors
In conclusion, a single bout of TC exercise had a significant positive effect on blood adiponectin concentrations in individuals with cardiovascular risk factors. Content Type Journal ArticleDOI 10.1007/s00421-010-1628-yAuthors Rei-Yeuh Chang, Division of Cardiology, Department of Internal Medicine, Chia-Yi Christian Hospital, Chiayi, Taiwan, ROCMalcolm Koo, Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan, ROCMeng-Ying Ho, Department of Food Science, National Chiayi University, 300 University Road, Chiayi, Taiwan, ROCZi-Zi Lin, Department of Food Science, National Chiayi University, 300 University Road, Chiayi, Taiwan, ROCZer-Ran Yu, Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan, ROCYen-Fen Lin, Laboratory Medici...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients
Conclusions&nbsp;&nbsp; SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with repaglinide therapeutic efficacy in Chinese T2DM patients. Content Type Journal ArticleDOI 10.1007/s00228-010-0882-6Authors Qiong Huang, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan 410078, People?s Republic of ChinaJi-Ye Yin, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan 410078, People?s Republic of ChinaXing-Ping Dai, Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan 410078, People?s Republic of ChinaJing Wu, Department of Endocrinology, The XiangYa Hospital, Cent...
ESC: Pre-Procedure Statins May Cut MI Risk (CME/CE)
STOCKHOLM (MedPage Today) -- Statins delivered before invasive procedures appear to reduce the occurrence of cardiovascular events, a meta-analysis showed. (Source: MedPage Today Cardiovascular)
Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model.
Conclusion: The presence of metabolic syndrome in patients with hypertension significantly inflates economic burden and costs are likely to increase in the future due to an aging population and an increase in the prevalence of components of metabolic syndrome. (Source: BMC Public Health - Latest articles)
ESC: Statins Do Not Raise Cancer Rates and Mortality
Statin therapy does not appear to be associated with increased cancer rates and mortality, according to research presented at the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in Stockholm, Sweden. (Source: Modern Medicine)
ESC: With MI, Non-Cardiac Surgery, Statins Lower MI Risk
Administration of a pre-procedural statin drug significantly reduces myocardial infarction after both percutaneous coronary intervention and non-cardiac surgery, and also lowers the risk of atrial fibrillation after coronary artery bypass grafting, according to research published online Aug. 30 in the Journal of the American College of Cardiology to coincide with the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in Stockholm, Sweden. (Source: Modern Medicine)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Transient Increase in HDL-Cholesterol During Weight Gain by Hyperalimentation in Healthy Subjects.
Authors: Lindström T, Kechagias S, Carlsson M, Nystrom FH Determination of lipid levels is fundamental in cardiovascular risk assessment. We studied the short-term effects of fast food-based hyperalimentation on lipid levels in healthy subjects. Twelve healthy men and six healthy women with a mean age of 26 +/- 6.6 years and an aged-matched control group were recruited for this prospective interventional study. Subjects in the intervention group aimed for a body weight increase of 5-15% by doubling the baseline caloric intake by eating at least two fast food-based meals a day in combination with adoption of a sedentary lifestyle for 4 weeks. This protocol induced a weight gain from 67.6 +/- 9.1 kg to 74.0 +/- 11 kg (P &lt; 0.001). A numerical increase in the levels of high-density l...
Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis.
CONCLUSIONS: Decreasing plasma SM levels through decreasing SMS2 activity could become a promising treatment for atherosclerosis. PMID: 20814016 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Cholesterol Intake Modulates Plasma Triglyceride Levels in GPIHBP1-Deficient Mice.
CONCLUSIONS: Treatment of Gpihbp1(-/-) mice with ezetimibe lowers Lpl expression in the liver and increases plasma triglyceride levels. A high-cholesterol diet had the opposite effects. Thus, cholesterol intake modulates plasma triglyceride levels in Gpihbp1(-/-) mice. PMID: 20814015 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Ameliorative effect of sesame lignans on nicotine toxicity in rats.
Authors: Chattopadhyay K, Mondal S, Chattopadhyay B, Ghosh S Nicotine causes oxidative and genotoxic damages in the tissues leading to several diseases. Any strategy through natural diet that prevents or slows the progression and severity of nicotine toxicity has a significant health impact. This work is designed to investigate natural antioxidants that play effective protective role against nicotine-induced toxicity. Experiments were conducted on male albino rats by injecting nicotine tartrate (3.5mg/kg body wt./day for 15days) subcutaneously and thereby supplementing sesame lignans (0.1g/100g diet and 0.2g/100g diet) orally to them. Significant (P&lt;0.01) increase of total cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol, decrease of HDL-cholesterol, decrease in antioxid...
Statins in women for primary prevention - is there evidence to back up their use??
Authors: Fenton A, Panay N PMID: 20738236 [PubMed - in process] (Source: Climacteric)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Balanced diet cuts heart risk
Conclusion This well-conducted trial benefits from its relatively large size, accurate provision of the three randomised diets and high study completion rates (95%). It also featured a reliable study outcome by using the average of a series of blood pressure measures, which is preferable to relying on a single blood pressure reading. The study found that eight weeks of the DASH diet, which was rich in fruit and vegetables and low in saturated fat, lowered blood pressure and cholesterol. This contributed to a decrease in predicted 10-year CHD risk. The DASH diet reduced this risk by 18% compared to a high-saturated fat ?American? diet and by 11% compared to a diet similar to the American diet but with higher intake of fruit and vegetables. Some points to note when interpreting this stud...
Stronger Heart, Better Sex, and Higher Performance At Any Age
You can tap a reserve of energy inside your body big enough to turbo-charge your heart, lungs, muscles, and your bedroom performance. And it doesn?t matter how old you are or what condition you?re in. You can use this Olympic athlete?s secret even if you?re not likely to be competing in any sports. Elite athletes use a combination of nutrients that allow their blood vessels to relax, giving them bigger blood flow and a surge of oxygen to every cell in their body whenever they want it. Bigger blood flow increases their muscle mass, powers up their performance levels, multiplies their heart?s pumping power, and gives them a lift in the bedroom. Unfortunately, medicine is so dominated by drug therapy, you may get the impression that to stay healthy and vigorous, you need to supple...
Findings of a U.S. National Cardiometabolic Screening Program Among 10,084 Psychiatric Outpatients [Articles]
CONCLUSIONS: The prevalence of metabolic syndrome and cardiometabolic risk factors, such as overweight, hypertension, dyslipidemia, and glucose abnormalities, was substantial and frequently untreated in this U.S. national mental health clinic screening program. (Source: Psychiatr Serv)
Data From Mipomersen Phase 3 Trial In heFH Patients Presented At ESC
Genzyme Corp. (NASDAQ: GENZ) and Isis Pharmaceuticals Inc. (NASDAQ: ISIS) announced that data from the phase 3 study of mipomersen in patients with heterozygous familial hypercholesterolemia (heFH) were presented at the European Society of Cardiology's Congress 2010 in Stockholm, Sweden. The study met its primary endpoint with a 28 percent reduction in LDL-cholesterol, compared with an increase of 5 percent for placebo (pThis double-blind, placebo-controlled phase 3 study was designed to test the efficacy and safety of adding mipomersen to stable lipid-lowering therapy... (Source: Health News from Medical News Today)
Heart news digest
Statins and cancer, insomnia, crisps and father and son's 'end to end' cycle ride (Source: BHF National News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Separating the Contribution of Glucocorticoids and Wakefulness to the Molecular and Electrophysiological Correlates of Sleep Homeostasis
Conclusions: Our findings indicate that corticosterone contributes to the sleep-deprivation&ndash;induced changes in brain transcriptome that have been attributed to wakefulness per se. The study identified 78 transcripts that respond to sleep loss independent of corticosterone and time of day, among which genes involved in neuroprotection prominently feature, pointing to a molecular pathway directly relevant for sleep function. Keywords: Sleep regulation, corticosterone, neuroprotection, microarray, microRNA (Source: Sleep)
DASH Eating Plan Lowers Long-Term Heart Attack Risk, Especially Among African-Americans
The DASH eating plan, known to reduce blood pressure and bad cholesterol, also reduces the 10-year risk of heart attack, especially among African-Americans, according to research reported in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. The DASH eating plan emphasizes fruits, vegetables and low-fat dairy products as well as whole grains, poultry, fish and nuts. The plan also calls for a reduction in fats, red meat, sweets, and sugar-containing beverages. It is recommended by the U.S. government and American Heart Association... (Source: Health News from Medical News Today)
Simplifying cardiovascular risk estimation using resting heart rate
Conclusion Addition of RHR to formulas already containing lipid and blood pressure measures does not appreciably improve risk estimation. However, inclusion of RHR in simple systems, which can potentially enhance cost-effectiveness and accessibility of risk estimation, is useful. (Source: European Heart Journal)
Netherlands Study Shows Need For Dose Management Care When Switching To Generic Statins
Research conducted in the Netherlands has highlighted the need for care when switching patients under treatment for high cholesterol from branded to generic drug families. The study shows that much of the switching can result in patients inadvertently receiving non-equivalent doses, potentially leading to an increased risk of downstream heart disease and stroke. Guidelines have been issued by many national healthcare providers to switch patients away from more expensive branded versions of drugs... (Source: Health News from Medical News Today)
Review Finds No Statin-Cancer Link
Title: Review Finds No Statin-Cancer LinkCategory: Health NewsCreated: 8/31/2010 12:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cancer General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Review Finds No Statin-Cancer Link
Title: Review Finds No Statin-Cancer LinkCategory: Health NewsCreated: 8/31/2010 12:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cholesterol General)
'DASH Diet' Shown to Lower Heart Attack Risk Almost 20%
Title: 'DASH Diet' Shown to Lower Heart Attack Risk Almost 20%Category: Health NewsCreated: 8/31/2010 4:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cholesterol General)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find (Source: Cancercompass News: Other Cancer)
Atherogenic dyslipidemia commonly found with stable coronary disease
A significant proportion of patients with coronary artery disease could benefit from efforts to increase their high-density lipoprotein cholesterol levels and reduce triglycerides, researchers say. (Source: MedWire News - Lipidology)
Editorial - Effect of statins on serum prostate-specific antigen levels
BERKELEY, CA (UroToday.com) - In the online edition of the... (Source: UroToday)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Beyond statin therapy: a review of the management of residual risk in diabetes mellitus
This article will review dyslipidaemia and its role in DM, and will discuss available treatment modalities that address residual cardiovascular risk in this disease. (Source: JRSM)
Angina pill reduces CV death risk for heart failure patients
Ivabradine cut risk of CV death/hospitalisation from heart failure by 18%Related items from OnMedicaIgnored cholesterol blamed for heart attacksHospitals fail women with myocardial infarctionPoor patients more likely to die after heart surgery than richPolypill could halve cardiovascular events NICE should adopt new risk score for heart disease (Source: OnMedica Latest News)
Intracellular molecular effects of insulin resistance in patients with metabolic syndrome
Conclusions In patients with MetS, we found a reduction of mTOR and other mTOR-related molecules involved in insulin resistance, cell repair, coagulation and vasculogenesis. A reduced expression of mTOR may reflect an increased risk of vascular thrombosis. (Source: Cardiovascular Diabetology)
Effects of a sphingolipid-enriched dairy formulation on postprandial lipid concentrations
Authors: L Ohlsson, H Burling, R-D Duan & &#197; Nilsson (Source: European Journal of Clinical Nutrition)
The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial
Authors: X Lin, S B Racette, M Lefevre, C A Spearie, M Most, L Ma & R E Ostlund (Source: European Journal of Clinical Nutrition)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The Effect of Nitric Oxide and Statins on Thrombospondin-1-Induced Chemotaxis in Vascular Smooth Muscle Cells
Vascular smooth muscle cell (VSMC) chemotaxis is important in intimal hyperplasia (IH). Nitric oxide (NO), a diffusible molecule that decreases VSMC chemotaxis to several growth factors, is protective against IH. Thrombospondin-1 (TSP-1), a matricellular glycoprotein that induces VSMC chemotaxis, acts antagonistically to NO in VSMCs. Statins exhibit direct and pleiotropic effects on VSMCs. We showed overnight treatment with lovastatin inhibited TSP-1-induced VSMC chemotaxis by mevalonate pathway inhibition and was Ras dependent. Hypothesis: Short-term statin treatment will inhibit TSP-1-induced VSMC chemotaxis and NO donors will enhance statin inhibitory effects. (Source: Journal of Vascular Surgery)
Regarding ?Preoperative statin therapy is associated with improved outcomes and resource utilization in patients undergoing aortic aneurysm repair?
McNally et al demonstrated, in their retrospective analysis of 401 patients undergoing elective abdominal aortic aneurysm repair, that postoperative mortality rate was significantly decreased in the open repair statin cohort compared with the nonstatin open repair cohort and trended to be decreased in the endovascular repair statin group. Previous meta-analyses, which combined unadjusted odds ratios (ORs) in nonrandomized studies, also suggested that preoperative statin therapy was associated with lower postoperative mortality after vascular surgery. Since these meta-analyses were conducted, however, results of a number of controlled studies have been reported to date. In the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography III (DECREASE III) trial, a recent...
Reply
We read the comments from Takagi et al with great interest. Their letter outlines an interesting and thought-provoking meta-analysis demonstrating the protective benefits of preoperative statin therapy in patients with noncoronary vascular disease. In addition to the studies cited in our manuscript, this letter cites several other important sources which add credence to our hypothesis regarding the influence of statin-class drugs on operative outcomes and resource utilization after aneurysm surgery. Takagi et al should be commended for this analysis, and we would urge the authors to consider a robust publication of the methodology and data. (Source: Journal of Vascular Surgery)
Correlation between unconjugated bilirubin and total cholesterol in the sera of 1?month?old infants
(Source: Journal of Paediatrics and Child Health)
Body mass index, waist circumference, and cardiometabolic risk factors in young and middle-aged Chinese women.
Conclusions: The prevalence of overweight/obesity and abdominal obesity was high in Chinese young and middle-aged women. BMI was a better predictor of cardiovascular disease and diabetes than WC in young and middle-aged women, and moreover, measurement of both WC and BMI may be a better predictor of cardiovascular disease and diabetes mellitus than BMI or WC alone. PMID: 20803767 [PubMed - as supplied by publisher] (Source: J Zhejiang Univ Sci ...)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Effects of consuming diets containing various fats or citrus flavanones on plasma lipid and urinary F2-isoprostane concentrations in overweight cats.
Conclusions and Clinical Relevance-Although the clinical relevance of these findings is unknown, the significant differences detected indicated that lower energy intake with citrus flavanones supplementation or with substitution of saturated fat for monounsaturated fat could be good strategies for decreasing plasma lipids concentration and oxidative stress in overweight cats, even before considerable loss of body weight is observed. (Am J Vet Res 2010;71:1039-1044). PMID: 20807143 [PubMed - in process] (Source: American Journal of Veterinary Research)
A comparative study of dyslipidaemia in men and woman with androgenic alopecia.
Authors: Arias-Santiago S, Guti Eacute Rrez-Salmer Oacute N MI, Buend Iacute A-Eisman AI, Gir Oacute N-Prieto MS, Naranjo-Sintes RO Several studies have analyzed the relationship between androgenetic alopecia and cardiovascular disease (mainly heart disease). However few studies have analyzed lipid values in men and women separately. This case-control study included 300 patients consecutively admitted to an outpatient clinic, 150 with early onset androgenetic alopecia (80 males and 70 females) and 150 controls (80 males and 70 females) with other skin diseases. Female patients with androgenic alopecia showed significant higher triglycerides values (123.8 vs 89.43 mg/dl, p = 0.006), total cholesterol values (196.1 vs 182.3 mg/dl, p = 0.014), LDL-C values (114.1 vs 98.8 mg/dl, p = 0.0006...
Metabolic Syndrome, Its Components, and Mortality in the Elderly.
Conclusions: By showing that an elevated fasting blood glucose potentiates the excess mortality risk associated with lipid abnormality, our study supports the status of MetS as a risk factor for mortality in the elderly. Our findings emphasize the importance of MetS screening and managing dyslipidemia and hyperglycemia in older persons in general practice. PMID: 20810578 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Ethnic Differences in the Relationship between Pericardial Adipose Tissue and Coronary Artery Calcified Plaque: African-American-Diabetes Heart Study.
Conclusions: Pericardial adiposity is strongly associated with coronary atherosclerosis in AA with type 2 diabetes. Novel cardiovascular disease risk factors such as PAT may contribute to ethnic disparities in susceptibility to development of coronary atherosclerosis. PMID: 20810573 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study.
CONCLUSIONS In patients with stable CAD who are free from heart failure at baseline, diabetes and glycemic control are independent risk factors for new-onset heart failure. The mechanisms by which diabetes and hyperglycemia lead to heart failure deserve further study, as the association is independent of baseline functional assessment of ischemia, systolic and diastolic function, and interim myocardial infarction. PMID: 20805280 [PubMed - in process] (Source: Diabetes Care)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with type 2 diabetes.
CONCLUSIONS Compared with simvastatin, atorvastatin reduced hsCRP and its variability in type 2 diabetic patients. This enhanced anti-inflammatory effect may prove beneficial if lower CRP is associated with improved cardiovascular risk. PMID: 20805273 [PubMed - in process] (Source: Diabetes Care)
Red meat from animals offered a grass diet increases plasma and platelet n-3 PUFA in healthy consumers.
Authors: McAfee AJ, McSorley EM, Cuskelly GJ, Fearon AM, Moss BW, Beattie JA, Wallace JM, Bonham MP, Strain JJ Red meat from grass-fed animals, compared with concentrate-fed animals, contains increased concentrations of long-chain (LC) n-3 PUFA. However, the effects of red meat consumption from grass-fed animals on consumer blood concentrations of LC n-3 PUFA are unknown. The aim of the present study was to compare the effects on plasma and platelet LC n-3 PUFA status of consuming red meat produced from either grass-fed animals or concentrate-fed animals. A randomised, double-blinded, dietary intervention study was carried out for 4 weeks on healthy subjects who replaced their habitual red meat intake with three portions per week of red meat (beef and lamb) from animals offered a finis...
Vulnerable disease may induce neointimal coverage after silorimus-eluting stent implantation
Conclusion: Vulnerable disease may promote neointimal coverage after SES implantation. (Source: American Heart Journal)
lipid co?sorting mediated by shiga toxin induced tubulation
To maintain cell membrane homeostasis, lipids must be dynamically redistributed during the formation of transport intermediates but the mechanisms driving lipid sorting are not yet fully understood. Lowering sphingolipid concentration can reduce the bending energy of a membrane, and this effect could account for sphingolipid depletion along the retrograde pathway. However, sphingolipids and cholesterol are enriched along the anterograde pathway, implying that other lipid sorting mechanisms, such as protein?mediated sorting, can dominate. To characterize the influence of protein binding on the lipid composition of highly?curved membranes, we studied the interactions of the B?subunit of Shiga toxin (STxB) with Giant Unilamellar Vesicles (GUVs) containing its glycosphingolipid receptor,...
Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats.
Authors: Neese SL, Korol DL, Katzenellenbogen JA, Schantz SL Estrogens act in the adult brain to modulate cognition, enhancing performance on some learning tests and impairing performance on others. Our previous research has revealed an impairing effect of chronic 17beta-estradiol treatment in young and aged rats on a prefrontally-mediated working memory task, delayed spatial alternation (DSA). Little is known about the mechanisms of these impairing effects. The current study examined the effects of selective estrogen receptor (ER) alpha or ERbeta activation on DSA performance in middle-aged female rats. Ovariectomized 12 month old Long Evans (LE) rats were treated by subcutaneous injection with the ERalpha agonist propyl pyrazole triol (PPT) or the ERbeta agonist diarylpropionitrile (...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Major study finds no evidence that statins cause cancer
In the largest and most reliable study of its type, researchers in the UK and Australia have demonstrated that statin therapy is not a cause of increased cancer rates and deaths. (Source: ScienceDaily Headlines)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find (Source: The Doctors Lounge - Cardiology)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find Source: HealthDay Related MedlinePlus Pages: Cancer, Statins (Source: MedlinePlus Health News)
Statins and cancer
Statins do not raise risk of cancer (Source: BHF National News)

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