causes of high cholesterol

Below, you'll find up to date information, and "causes of high cholesterol" reports and resources to help you with your awareness of Cholesterol. The Team at Awareness-Guide.com hope you find the answers you are looking for.

Four Main Factors Causing High Cholesterol
james ellison

Besides diet, other causes of high are lifestyle, gender and the heritage of the individual.

For some, even maintaining at the right levels and being fit and thin will still not prevent the development of high levels of bad cholesterol. Due to heart risk factors besides diet, some people require a very aggressive approach which includes lowing medication.

Lifestyle issues and high cholesterol:

•When we opt for convenience in eating over nutrition, we are setting ourselves up for problems. Eating fast foods and convenience foods results in eating too many fats and salts, which can raise our bad levels. In addition, a more sedentary lifestyle also contributes to unhealthy levels of cholesterol. If you want to see a graphic representation of this, consider renting the documentary movie “Supersize Me.” This documentary details the attempts of one man to live on fast foods and little exercise alone. The results on his and body health in just 30 days are truly frightening.

•A visit to a nutritionist or dietician can help us all better understand eating for the right reasons and for optimal health. It is never too late to start on this path.

•Regular exercise will effectively lower and will maintain your body strength to function best. Just 20 minutes of aerobic exercise, including walking, each day will lower cholesterol. Exercise does not have to be a large time or money commitment. Simple activities that get you moving and that you enjoy enough to repeat are almost always adequate.

Diet:

•An important consideration in eating is choosing lower fat.

•Buy cooking oils that are unsaturated. Use low fat cooking sprays to replace heavy oils whenever possible. Reduce your overall use of oils even further by using cooking techniques that require little or no oil.

Age and Gender:

•Cholesterol levels increase with age. Women generally have a lower level than men from age 50 to 55. Once a woman starts menopause, the level starts to increase.

• While there is not much that you can do about your age, you can make sure that age does not threaten your heart health by sticking to a healthy lifestyle and diet and by getting your levels monitored.

Heritage:

•Genetics play a key role in a person's health and this includes the amount of you might have.

•Find out if your family battles with high levels of and then bring this to your doctor’s attention right away. If you have a family history of heart disease and high levels, work harder and start earlier in adopting a healthy lifestyle and eating plan.

James makes it easy for you to understand the different low carb diets. If you need to know more about low carb dieting visit: Low Carb Diets

Additional Resources Tips That Doctors Know That Teach You How To Lower Cholesterol By Jimmy High cholesterol is one of the leading causes of heart disease and heart attacks in the world today. Millions of people are afflicted with high cholesterol whether it is because of heredity or diet. Read more...

Additional Resources Know Your Cholesterol Levels By Julia Carmichael Cholesterol is a sterol lipid, a form of fat, found in the cell membranes of all body tissues of humans and animals. Most of it is synthesized internally in the liver, but a part of it comes directly Read more...

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And again, thank you to those contributing daily to our Cholesterol Website, especially regarding "causes of high cholesterol".

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Authors: Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nu&#241;ez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung & Eicke Latz Nature464, 1357&#8211;1361 (2010)In this Letter, the address for author Veit Hornung was listed incorrectly. The correct address is: The Institute of Clinical Chemistry and Pharmacology, University Hospitals, University of Bonn, 53127 Bonn, Germany. Also, Veit Hornung was (Source: Nature)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Pharmaceutical drug contamination of waterways threatens life on our planet
This study was the first national-scale evaluation of pharmaceutical drug contamination in streams, and roughly 80 percent of the streams tested were found to be contaminated as well.In 2008, an AP investigation found that at least 46 million Americans are drinking water contaminated with trace amounts of pharmaceuticals. Even though every city tested has its water treated and "purified" prior to being delivered to the public, trace amounts of pharmaceutical drugs are making their way through to the tap. (Since not all major metropolitan areas were tested, the number of people affected is likely far higher than what was reported by AP.)In spite of all this, water quality reports don't disclose the levels of pharmaceuticals found in tap water. Since the EPA and FDA have failed to establish ...
Effect of saturated fatty acid-rich dietary vegetable oils on lipid profile, antioxidant enzymes and glucose tolerance in diabetic rats
Conclusion : The type of FA in the dietary oil determines its deleterious or beneficial effects. Lauric acid present in CO may protect against diabetes-induced dyslipidemia. (Source: Indian Journal of Pharmacology)
Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats
Conclusion : Because diminished cholinergic transmission and increase in cholesterol levels appear to be responsible for the development of amyloid plaques and dementia in Alzheimer patients, PA may prove to be a useful memory-restorative agent. It would be worthwhile to explore the potential of this plant in the management of Alzheimer&#x0027;s disease. (Source: Indian Journal of Pharmacology)
New Hope for Chronic Kidney Disease Patients After the JUPITER Trial: Myth or Reality?
In their recent paper, Ridker et al. () performed a secondary analysis of JUPITER (Justification for the Use of Statins in Prevention?an Intervention Trial Evaluating Rosuvastatin) to assess the efficacy of rosuvastatin for primary prevention in patients with moderate chronic kidney disease (CKD). According to their results, rosuvastatin reduces first cardiovascular events and all-cause mortality among men and women with low-density lipoprotein cholesterol (Source: Journal of the American College of Cardiology)
Reply
We thank Drs. Roberts and Hare for their interest in our paper describing cardiovascular outcomes among JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin) participants classified according to their baseline renal function status. We agree that there are limitations of the Modification of Diet and Renal Disease equation for estimating glomerular filtration rate (GFR) and that our analysis was based on the Modification of Diet and Renal Disease estimate of GFR using a single baseline serum creatinine level. We also acknowledge that the variability of serum creatinine can influence estimated glomerular filtration rate (eGFR), particularly among individuals with lower serum creatinine levels. Recognizing these limitations, we con...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
JUPITER ?Moderate CKD? Subgroup Is Not Truly ?Moderate? Chronic Kidney Disease
Given that trials of lipid lowering in patients with chronic kidney disease (CKD) requiring dialysis have been neutral (), and the only evidence for lipid-lowering therapy in patients with CKD not requiring dialysis is based on secondary analyses, such as the Pravastatin Pooling Project (), it is commendable that a subgroup defined by kidney function was examined in JUPITER (Justification for the Use of Statins in Prevention?an Intervention Trial Evaluating Rosuvastatin), as reported recently in this journal (). However, we do not believe that it is appropriate to call this a subgroup with ?moderate CKD.? (Source: Journal of the American College of Cardiology)
Abbott's SIMCOR(R) (niacin extended-release / simvastatin) Receives FDA Approval for New Dosage Strengths
ABBOTT PARK, Ill., July 28 (HSMN NewsFeed) -- Abbott (NYSE:ABT ) today received U.S. Food and Drug Administration (FDA) approval for two new dosage strengths of SIMCOR&reg;, a cholesterol medication. The new SIMCOR dosage strengths combine 40 mg of simv... Biopharmaceuticals, Cardiology, FDAAbbott, SIMCOR, niacin, simvastatin, cholesterol (Source: HSMN NewsFeed)
Nutrients and risk of prostate cancer.
This study assesses the association between intake of protein, fats, cholesterol, and carbohydrates and the risk of prostate cancer (PCa). Between 1994 and 1997, in 8 Canadian provinces, mailed questionnaires were completed by 1,797 incident, histologically confirmed cases of PCa and 2,547 population controls. Information was collected on socioeconomic status, lifestyle habits, and diet. A 69-item food frequency questionnaire provided data on eating habits 2 yr before the study. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using unconditional logistic regression, including terms for sociodemographic factors, body mass index, alcohol, and total energy intake. Intake of trans fat was associated with the risk of PCa; the OR for the highest vs. the lowest quartile was 1.4...
Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome
Rimonabant (SR141716) is a specific antagonist of the cannabinoid-1 receptor. Activation of the receptor initiates multiple effects on central nervous system function, metabolism, and body weight. The hypothesis that rimonabant has protective effects against vascular disease associated with the metabolic syndrome was tested using JCR:LA-cp rats. JCR:LA-cp rats are obese if they are cp/cp, insulin resistant, and exhibit associated micro- and macrovascular disease with end-stage myocardial and renal disease. Treatment of obese rats with rimonabant (10 mg&middot;kg&ndash;1&middot;day&ndash;1, 12&ndash;24 wk of age) caused transient reduction in food intake for 2 wk, without reduction in body weight. However, by 4 wk, there was a modest, sustained reduction in weight gain. Glycemic control imp...
FDA clears Abbott's Simcor for two new dosage strengths
The FDA has approved two new dosage strengths of Abbott's Simcor, a cholesterol medication. (Source: Cardiovascular Business News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Selective pediatric cholesterol screening ?misses at-risk individuals?
Using family history to guide selective blood cholesterol screening in children, as recommended by the US National Cholesterol Education Program, misses many individuals who would be eligible for pharmacologic therapy, say researchers. (Source: MedWire News - Lipidology)
Health Insurance and Cardiovascular Disease Risk Factors
Conclusion: The treatment and control of hypertension and hypercholesterolemia are lower among uninsured adults. Increasing the proportion of insured individuals may be a means to improve the treatment and control of cardiovascular disease risk factors and to reduce health disparities. (Source: The American Journal of Medicine)
Beyond the Abstract - Cholesterol and phytosterols differentially regulate the expression of ...
BERKELEY, CA (UroToday.com) - Over the last few years, epidemiological and population studies have suggested that African Americans have a... (Source: UroToday)
Statins for children with familial hypercholesterolemia
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Familial hypercholesterolemia is one of the most common inherited metabolic diseases; the average worldwide prevalence of heterozygous familial hypercholesterolemia is about 1 in 500. Diagnosis of familial hypercholesterolemia in children is based on two measurements of low-density lipoprotein cholesterol level above 4.0 mmol/L or a DNA-based analysis. Coronary stenosis has been detected in men with familial hypercholesterolemia as young as 17 years old and in women with familial hypercholesterolemia at 25 years old. Atherosclerosis and its clinical complications occur prematurely, especially in men, thus lifelong hypolipidemic measures, started in childhood, are needed to reduce the risk of cardiovascular disea...
Crestor 5mg, 10mg, 20mg and 40mg film-coated tablets (Rosuvastatin calcium) - Revised SPC
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC changes includes: &nbsp; Section 1 Additional Text: * Intensive monitoring is requested only when used for the recently licensed indication of prevention of cardiovascular events and paediatric use." &nbsp; Section 4.1 Additional first heading: "Treatment of hypercholesterolaemia" &nbsp; Additional text to first paragraph: "Adults, adolescents and children aged 10 years or older with primary hypercholesterolaemia (type IIa including heterozygous familial hypercholesterolaemia) or mixed dyslipidaemia (type IIb) as an adjunct to diet when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) is inadequate." &nbsp; Addition of 3...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
DOH "Quality, Innovation, Productivity and Prevention (QIPP)" 2010/11 report on medicines management
Source: Department of Health (DH) Area: News In response to the challenges of the current economic climate within the NHS, the Department of Health's has focussed on identifying areas where it can simultaneously improve the quality of care and release substantial efficiency savings, by working at scale and pace across the NHS. This work is called 'Quality, Innovation, Productivity and Prevention (QIPP)'. &nbsp; This QIPP report identifies some key therapeutic medicines management options for local implementation in 2010/11. It has been produced following a multidisciplinary scoping exercise, undertaken to identify a validated list of options for maximising efficient use of NHS spending on primary care prescribing, whilst maintaining quality, in the context of a challenging medium term...
Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis
Background: Several studies demonstrated an association of homocysteine plasma levels and the plasma lipoprotein profile. This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile. Methods: In a retrospective single center approach, we analyzed the laboratory database (2003-2006) of the University Hospital Bonn, Germany, including 1743 individuals, in whom vitamin B12, folate and at least one lipoprotein parameter had been determined by linear multilogistic regression. Results: Higher folate serum levels were associated with lower serum levels of low density lipoprotein cholesterol (LDL-C; Beta=-0.164; p (Source: Nutrition Journal)
Loose cholesterol, get stiff! Focus on "oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation"
(Source: AJP: Cell Physiology)
oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation
In this study, we show that oxLDL induces a decrease in lipid order of membrane domains and that this effect is inversely correlated with endothelial stiffness, contractility, and network formation. Local lipid packing of cell membrane domains was assessed by Laurdan two-photon imaging, endothelial stiffness was assessed by measuring cellular elastic modulus using atomic force microscopy, cell contractility was estimated by measuring the ability of the cells to contract collagen gels, and EC angiogenic potential was estimated by visualizing endothelial networks within the same gels. The impact of oxLDL on endothelial biomechanics and network formation is fully reversed by supplying the cells with a surplus of cholesterol. Furthermore, exposing the cells to 7-keto-cholesterol, a major oxyst...
If You?re Laughing, You?re Living?Longer
Dear Health Conscious Reader, Do you want to hear the funniest joke in the world? If you do searches for the ?funniest joke in the world,? this is the most common winner for U.S. audiences? A couple of hunters are out in the woods when one of them grabs his chest, falls to the ground, and then lies there motionless. The other hunter calls 911. ?My friend won?t get up, and I think he?s dead! What should I do?? The operator, in a calm, soothing voice, says: ?Just take it easy. I can help. First, you have to make sure he?s dead.? There?s a silence? then the operator hears two shots. The hunter?s voice comes back on the line. ?Okay, what do I do next?? Now? I know jokes that I think are a lot funnier, but they?re a little too risqué to put in your letter. But...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands [Pharmacology]
The microsomal antiestrogen binding site (AEBS) is a high-affinity target for the antitumor drug tamoxifen and its cognate ligands that... (Source: Proceedings of the National Academy of Sciences)
FDA Alert - Vialipro Dietary Supplement Recalled: Undeclared Drug Ingredient
The undeclared ingredient may pose a threat to the consumer because the interaction of the analogue with some prescription drugs (such as nitroglycerin) may lower blood pressure to dangerous levels. Consumers with diabetes, high blood pressure, high cholesterol, or heart disease often take other prescription drugs. (Source: NCCAM Featured Content)
Final Results of the Protected Superficial Femoral Artery Trial Using the FilterWire EZ System
Abstract&nbsp;&nbsp;The purpose of this study was to evaluate the safety and efficacy of debris-capture for distal protection using the FilterWire EZ Embolic Protection System (Boston Scientific, Mountain View, CA) with the additional aim to further define the incidence of distal embolization during superficial femoral artery (SFA) interventions. A prospective, single-centre registry was designed to evaluate the performance of the FilterWire EZ in capturing debris during standard SFA percutaneous intervention. The PRO-RATA study included 30 patients suitable for PTA (Fontaine IIb to III or Rutherford I to II classification). The primary end points were occurrence of distal embolization or decreased runoff, improvement in ankle?brachial index ankle?brachial index (ABI) after the p...
Low on-treatment LDL levels confound HDL predictive ability
High-density lipoprotein cholesterol levels may not predict cardiovascular disease risk in statin-treated patients who have achieved very low levels of low-density lipoprotein cholesterol, indicates an analysis of the JUPITER trial. (Source: MedWire News - Lipidology)
Preventing Heart Problems While Keeping A Cool Head
Max Planck researchers explain the cause of the flushing effect arising from cholesterol treatment with nicotinic acid. Cholesterol influences the health of our hearts and blood vessels. Conventional treatment attempts to reduce the level of "bad" cholesterol, LDL cholesterol, in the blood plasma. The opposite approach, which involves increasing the concentration of "good" HDL cholesterol using nicotinic acid, has proven unpopular among patients up to now... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Scientists discover olive oil directly impacts genes to halt inflammation
(NaturalNews) Research has been steadily accumulating that olive oil, a main component of the Mediterranean diet, has extensive health-protective properties. For example, phytonutrient components of olive oil have been found to be effective against breast cancer cells (http://www.naturalnews.com/025633_cancer_olive_oil_brst.html) and studies suggest the abundance of olive oil in the Mediterranean style of eating may be the reason that diet helps prevent depression (http://www.naturalnews.com/027265_depression_mediterranean_diet_health.html). Now scientists have discovered that phenolic compounds in olive oil directly repress genes linked to inflammation. This could be especially important in halting the dangerous effects of metabolic syndrome. Characterized by excess abdominal fat, high ch...
Link Between Depression, Cholesterol May Differ by Gender
Title: Link Between Depression, Cholesterol May Differ by GenderCategory: Health NewsCreated: 7/26/2010 2:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Depression General)
Link Between Depression, Cholesterol May Differ by Gender
Title: Link Between Depression, Cholesterol May Differ by GenderCategory: Health NewsCreated: 7/26/2010 2:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Cholesterol General)
Stroke Prevention Treatment Varies Widely Across U.S.
Title: Stroke Prevention Treatment Varies Widely Across U.S.Category: Health NewsCreated: 7/26/2010 4:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Cholesterol General)
Longer Time Frame for Clot-Busting Drug May Help Beat Stroke
Title: Longer Time Frame for Clot-Busting Drug May Help Beat StrokeCategory: Health NewsCreated: 7/26/2010 8:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Cholesterol General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
To Help Keep Weight Off, Turn to the Web
Title: To Help Keep Weight Off, Turn to the WebCategory: Health NewsCreated: 7/27/2010 8:10:00 AMLast Editorial Review: 7/27/2010 (Source: MedicineNet Cholesterol General)
Link Between Depression, Cholesterol May Differ by Gender
Title: Link Between Depression, Cholesterol May Differ by GenderCategory: Health NewsCreated: 7/26/2010 2:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Heart General)
Link Between Depression, Cholesterol May Differ by Gender
Title: Link Between Depression, Cholesterol May Differ by GenderCategory: Health NewsCreated: 7/26/2010 2:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Senior Health General)
Preventing heart problems while keeping a cool head: Cause of flushing effect arising from cholesterol treatment with nicotinic acid
Cholesterol influences the health of our hearts and blood vessels. Conventional treatment attempts to reduce the level of "bad" cholesterol, LDL cholesterol, in the blood plasma. The opposite approach, which involves increasing the concentration of "good" HDL cholesterol using nicotinic acid, has proven unpopular among patients up to now. The reason for this is that treatment with nicotinic acid has an unpleasant but harmless side-effect: the drug makes patients turn quite red in the face. Scientists have now discovered the mechanism behind this effect, which is known as flushing. This will enable the development of flush inhibitors and thereby the more effective prevention of cardiovascular diseases. (Source: ScienceDaily Headlines)
White matter fractional anisotropy is related to processing speed in metabolic syndrome patients: a case-control study.
Conclusion: We found significant correlations between WM alterations and cognitive impairment in MetSd patients, especially in the frontal lobe. These findings highlight the importance of MetSd prevention and control due to its association with structural and functional damage in the central nervous system. (Source: BMC Neurology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Is it effective to target treatment using just calculated CHD risk?
Statin prescribing for the primary prevention of CHD is based on risk calculated from long-term population data. Here, the author discusses the issues with the current risk models and suggests that money could be better spent on improved targeting through the use of a diagnostic test. Copyright © 2010 Wiley Interface Ltd (Source: Prescriber)
Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes
Background: Treatment guidelines recommend LDL-C as the primary target of therapy in patients with hypercholesterolemia. Moreover, combination therapies with lipid-lowering drugs that have different mechanisms of action are recommended when it is not possible to attain LDL-C targets with statin monotherapy. Understanding which treatment or patient-related factors are associated with attaining a target may be clinically relevant. Methods: Data were pooled from two multicenter, randomized, double-blind studies. After stabilization on simvastatin 20 mg, patients with coronary heart disease (CHD) alone and/or type 2 diabetes mellitus (T2DM) were randomized to ezetimibe 10 mg/simvastatin 20 mg (EZ/Simva) or simvastatin 40 mg. The change from baseline in low-density lipoprotein cholesterol (LDL-...
Addition of Soluble Soybean Polysaccharides to Dairy Products as a Source of Dietary Fiber
Increasing consumption of dietary fiber in food leads to many important health benefits: for example, reduction in blood cholesterol, reduced risk of diabetes, and improved laxation. Water soluble soybean polysaccharide (SSPS) is a dietary fiber extracted and refined from okara, a byproduct of soy manufacturing. It was incorporated into 3 categories of dairy-based products, thickened milkshake-style beverages, puddings, and low-fat ice cream, to the maximum amount without over-texturing the food. Rheological measurements and sensory tests were used to develop desirable SSPS-fortified products. From the rheological data, 4% SSPS-fortified dairy beverages and 4% SSPS -fortified puddings were in the range of commercial products. From sensory analyses, 4% SSPS-fortified dairy beverage with 0.0...
Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis
Conclusions&nbsp;&nbsp;Atorvastatin prevented mucosal damage and inflammation associated with 5-FU-induced OM, but the association of a higher dose of ATV with 5-FU induced hepatotoxicity and amplified leukopenia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1409-7Authors C. A. C. X. Medeiros, State University of Rio Grande do Norte Department of Biomedical Sciences Mossoró BrazilR. F. C. Leitão, Faculty of Medicine, Federal University of Ceará Department of Morphology Rua Delmiro de Farias, sn Fortaleza CE 60430-270 BrazilR. N. Macedo, Federal University of Ceará Department of Physiology and Pharmacology Fortaleza BrazilD. R. M. M. Barboza, Federal University of Ceará Department of Physiology and Pharmacology Fortaleza BrazilA. S. Gomes, Fed...
New links between cholesterol and depression in the elderly
Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one?s risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. However, new findings by French researchers suggest the link between increased cholesterol and depression may be complicated. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Link Between Depression, Cholesterol May Differ by Gender
Regulating 'good' and 'bad' levels may help prevent mood disorder among elderly, researchers say (Source: The Doctors Lounge - Cardiology)
Current Therapies and New Strategies for the Management of Alzheimer's Disease
Alzheimer&rsquo;s disease (AD) is a devastating neurodegenerative disorder that currently affects millions of Americans. There is no cure at present and no real long-term hope for patients with AD. While partially effective in improving symptoms, currently available treatments approved by the US Food and Drug Administration (FDA) do not halt progression of AD, or address the underlying mechanism of the disease, in part because the etiology of AD is still an active area of investigation. Identification of risk factors and the pathogenic mechanism of AD hold the promise of bringing forth novel treatments and perhaps even a cure. In this review, we will summarize some of the risk factors for AD, AD diagnosis, and current treatments. Novel therapeutic strategies such as inhibition of &beta;-am...
Link Between Depression, Cholesterol May Differ by Gender
Regulating 'good' and 'bad' levels may help prevent mood disorder among elderly, researchers say Source: HealthDay Related MedlinePlus Pages: Cholesterol, Depression, Seniors' Health (Source: MedlinePlus Health News)
No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
The European Society of Cardiology (ESC) is concerned that interpretations of a paper about cholesterol, published in the Lancet (1), could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol. Topics: Cardiovascular Disease Prevention - Risk Assessment and Management (Source: European Society of Cardiology)
Molecular Simulation of the DMPC-Cholesterol Phase Diagram
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Physical Chemistry B)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Rare And Common Genetic Variations Responsible For High Triglyceride Levels In Blood
It can make blood look like cream of tomato soup. Patients with high levels of triglycerides in their blood, a disease called hypertriglyceridemia (HTG) face an increased risk for heart disease and stroke. HTG affects one in 20 people in North America and is also associated with obesity, diabetes and pancreatitis. Most people now understand the importance of LDL, the bad cholesterol and HDL, the good cholesterol, to their overall health. But high triglycerides are like the Rodney Dangerfield of the lipid world: they get less respect and notoriety compared to their cholesterol cousins... (Source: Health News from Medical News Today)
Decreasing Atherosclerosis Risk By Inhibiting Fatty Acids In Immune Cells
Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. They report their findings in the July 23 issue of the Journal of Biological Chemistry. Atherosclerosis is the process through which fatty substances, such as cholesterol and cellular waste products accumulate in the lining of arteries... (Source: Health News from Medical News Today)
As Weight Goes Up, So Do Heart Risks
Title: As Weight Goes Up, So Do Heart RisksCategory: Health NewsCreated: 7/23/2010 12:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Cholesterol General)
Relationship Insecurity May Undermine Your Health
Title: Relationship Insecurity May Undermine Your HealthCategory: Health NewsCreated: 7/24/2010 8:10:00 AMLast Editorial Review: 7/26/2010 (Source: MedicineNet Cholesterol General)
Preventing heart problems while keeping a cool head
(Max-Planck-Gesellschaft) Max Planck researchers explain the cause of the flushing effect arising from cholesterol treatment with nicotinic acid. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Effect of carnitine on serum cholesterol of alcoholic cardiomyopathy dogs
Carnitine is known to be essential for metabolism regulation in some heart diseases such as coronary heart disease. We evaluated the effect of carnitine and valsartan on alcoholic cardiomyopathy (ACM); surprisingly, it was found that carnitine leads to variations in serum lipids. The results of our study, supported by cardiac function assessment, LVW/BW ratio, hematoxylin and eosin staining, and electron microscopic morphology, not only demonstrated the validity of our ACM model but also addressed the therapeutic benefits of carnitine and valsartan in antagonizing ACM development. The alcohol group displayed a high LVEDd and low EF and FS, indicating both heart failure and cardiac remodeling. Compared with the alcohol and alcohol/valsartan groups, the concentration of serum cholesterol in ...
Hypertension in Pregnancy and Later Cardiovascular Risk. Common Antecedents?
Conclusions-These results suggest that the positive association of preeclampsia and gestational hypertension with postpregnancy cardiovascular risk factors may be due largely to shared prepregnancy risk factors rather than reflecting a direct influence of the hypertensive disorder in pregnancy. PMID: 20660802 [PubMed - as supplied by publisher] (Source: Circulation)
No Firm Conclusions About HDL Cholesterol Can Be Drawn From JUPITER Sub-analysis
No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis Sophia Antipolis, 23 July 2010: The European Society of Cardiology (ESC) is concerned that interpretations of a paper about cholesterol, published in the Lancet (1), could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol. Caution, the ESC experts advise, should be displayed in the interpretation of the results... (Source: Health News from Medical News Today)
Two Therapies Slow Diabetic Eye Disease Progression
In high-risk adults with type 2 diabetes, researchers have found that two therapies may slow the progression of diabetic retinopathy, an eye disease that is the leading cause of vision loss in working-age Americans. Intensive blood sugar control reduced the progression of diabetic retinopathy compared with standard blood sugar control, and combination lipid therapy with a fibrate and statin also reduced disease progression compared with statin therapy alone. However, intensive blood pressure control provided no additional benefit to patients compared with standard blood pressure control... (Source: Health News from Medical News Today)
Reduction in cholesterol synthesis in response to serum starvation in lymphoblasts of a patient with Barth syndrome.
Authors: Hauff KD, Hatch GM Barth syndrome is a rare X-linked disease in which mild hypocholesterolemia is observed in some patients. We investigated cholesterol biosynthesis in lymphoblasts from a normal and age-matched Barth syndrome patient. Control and Barth syndrome (DeltaTAZ1) lymphoblasts were incubated in the presence or absence of serum to induce cholesterol synthesis and hydroxymethylglutaryl-coenzyme A reductase activity and expression, and cholesterol biosynthesis from radioactive precursors was determined. Cholesterol biosynthesis from [2-14C]pyruvate was stimulated 2-fold in control cells, but was unchanged in DeltaTAZ1 lymphoblasts, and from [1-14C]acetate was stimulated 77% in control but only 26% in DeltaTAZ1 lymphoblasts upon serum removal, indicating a lower ability ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Trends for type 2 diabetes and other cardiovascular risk factors in Mexico from 1993-2006.
CONCLUSIONS: This increasing trends for the prevalence of T2D and cardiovascular risk factors predicts larger increments in the near future for T2D and cardiovascular morbidity and mortality. Intensification of the preventive and remedy strategies is mandatory in order curve the foreseen dramatic increment in the disease burden. PMID: 20585732 [PubMed - in process] (Source: Salud Publica de Mexico)
Prevention of cardiovascular disease based on lipid lowering treatment: a challenge for the Mexican health system.
CONCLUSIONS: Thirty percent of Mexican adults require some form of lipid-lowering treatment (lifestyle modifications in 36.25%, drug therapy in 24.19%). PMID: 20585730 [PubMed - in process] (Source: Salud Publica de Mexico)
Prevalence of dyslipidemias in the Mexican National Health and Nutrition Survey 2006.
CONCLUSIONS: The ENSANUT 2006 data confirm that the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high. PMID: 20585729 [PubMed - in process] (Source: Salud Publica de Mexico)
Metabolic syndrome in Mexican adults: results from the National Health and Nutrition Survey 2006.
DISCUSSION: Regardless of the MS definition, a large proportion of Mexican adults has the condition, so preventive measures are needed to decrease the prevalence of the MS components in this population. MS can predict type 2 diabetes and cardiovascular disease, two of the main causes of death in the adult population in Mexico. The intentional search of MS components allows stratifying the population according to risk levels. Treatment for each component should be implemented properly to prevent or delay onset of type 2 diabetes and cardiovascular disease. PMID: 20585723 [PubMed - in process] (Source: Salud Publica de Mexico)
Comparing self-reported and measured high blood pressure and high cholesterol status using data from a large representative cohort study.
Conclusion: Although self-reported measures are consistent over time there are major differences between the self-reported measures and the actual clinical measurements. Technical aspects associated with clinic measurements could explain some of the difference. Implications: Monitoring of these broad population measures requires knowledge of the differences and limitations in population settings. PMID: 20649780 [PubMed - in process] (Source: Australian and New Zealand Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Protective Effects of Black Cumin (Nigella sativa) Oil on TNBS-Induced Experimental Colitis in Rats
Conclusions&nbsp;&nbsp;BCO, by preventing inflammatory status in the blood, partly protected colonic tissue against experimental ulcerative colitis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1333-zAuthors F. Isik, Marmara University Faculty of Dentistry, Department of Biochemistry Nisantas? 34365 Istanbul TurkeyTugba Tunali Akbay, Marmara University Faculty of Dentistry, Department of Biochemistry Nisantas? 34365 Istanbul TurkeyA. Yarat, Marmara University Faculty of Dentistry, Department of Biochemistry Nisantas? 34365 Istanbul TurkeyZ. Genc, Marmara University Faculty of Dentistry, Department of Biochemistry Nisantas? 34365 Istanbul TurkeyR. Pisiriciler, Marmara University Faculty of Dentistry, Department of Histology and Embryology Istanbul...
Conventional and Novel Drug Therapeutics to Relief Myocardial Ischemia
This article reviews drugs that alleviate the symptoms of chronic angina with emphasis on several novel pharmacological agents. Content Type Journal ArticleDOI 10.1007/s10557-010-6254-8Authors Danny Dvir, Tel Aviv University Cardiology Department, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine 49100 Tel Aviv IsraelAlexander Battler, Tel Aviv University Cardiology Department, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine 49100 Tel Aviv Israel Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Impact of generic competition on market share and prices of cardiovascular medicines on the Bulgarian pharmaceutical market
Abstract Background&nbsp;&nbsp;During the last three decades tremendous progress has been made in the discovery and development of a lot of new molecules in many pharmaceutical areas. These families of real innovative treatment comprise "originator" molecules (first molecule released, which can be under patent or with expired patent), as well a ?generic? version of those originator molecules, whose patent has expired. Usually the patent expires 15?20 years after the creation of the originator molecule. Main objective&nbsp;&nbsp;This research focuses on the effects of the arrival of generic and or therapeutic competitors on the market, in terms of impact on the market share and prices. Methodology&nbsp;&nbsp;Between 2005 and 2007 we follow three classes of medic...
Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease
Conclusion&nbsp;&nbsp;The results in this study suggest that the long-term EZ therapy can lead to improvement in metabolic, biochemical, and histological abnormalities of NAFLD. Therefore, EZ may be a promising agent for treatment of NAFLD. Content Type Journal ArticleCategory Original Article?Liver, Pancreas, and Biliary TractDOI 10.1007/s00535-010-0291-8Authors Hyohun Park, Saiseikai Suita Hospital Department of Gastroenterology and Hepatology 1-2 Kawazono-cho Suita Osaka 564-0013 JapanToshihide Shima, Saiseikai Suita Hospital Department of Gastroenterology and Hepatology 1-2 Kawazono-cho Suita Osaka 564-0013 JapanKanji Yamaguchi, Kyoto Prefectural University of Medicine Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science Kyoto JapanH...
Antihyperlipidemic effect of peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats
CONCLUSION: These results suggest that PPE has hypolipidemic effects in streptozotocin-induced diabetic rats. (Source: Clinics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Blood lipids, elderly depression, linked
MONTPELLIER, France, July 23 (UPI) -- Depression in women is linked to low levels of high-density lipoprotein, the "good" cholesterol, increasing their heart risk, French researchers say. High-density lipoprotein - France - blood lipid - Health - Cholesterol (Source: Health News - UPI.com)
Inhibiting Fatty Acids in Immune Cells Decreases Atherosclerosis Risk
July 23, 2010 (EurekAlert) - Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. They report their findings in the July 23 issue of the Journal of Biological Chemistry. read more (Source: Diabetes News from dLife.com)
Inhibiting Fatty Acids in Immune Cells Decreases Atherosclerosis Risk
July 23, 2010 (EurekAlert) - Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. They report their findings in the July 23 issue of the Journal of Biological Chemistry. read more (Source: Diabetes News from dLife.com)
ESC Press Statement: No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
July 23, 2010 (EurekAlert) - The European Society of Cardiology (ESC) is concerned that interpretations of a paper about cholesterol, published in the Lancet, could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol.  Caution, the ESC experts advise, should be displayed in the interpretation of the results. read more (Source: Diabetes News from dLife.com)
ESC Press Statement: No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
July 23, 2010 (EurekAlert) - The European Society of Cardiology (ESC) is concerned that interpretations of a paper about cholesterol, published in the Lancet, could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol.  Caution, the ESC experts advise, should be displayed in the interpretation of the results. read more (Source: Diabetes News from dLife.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
More From JUPITER: HDL Not Predictive of Risk at Very Low LDL Levels
A new post-hoc analysis of the JUPITER trial has shown that when patients have very low concentrations of LDL cholesterol attained through the use of potent statin therapy, "good" HDL cholesterol may no longer be predictive of cardiovascular risk. Although intriguing, the findings require further study, say the researchers and others. Heartwire (Source: Medscape Today Headlines)
[Adipocytokines and blood pressure, lipids and glucose metabolism in hypertensive perimenopausal women.]
Conclusions: In hypertensive postmenopausal females increased leptin level may play an important role in the pathogenesis of hypertension, independent of body mass index. Menopause per se does not affect blood pressure values. The influence of menopause on serum lipids may modulate the cardiovascular risk profile in postmenopausal females. Kardiol Pol 2010; 68, 7: 753-760. PMID: 20648430 [PubMed - as supplied by publisher] (Source: Kardiologia Polska)
Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
Abstract&nbsp;&nbsp;High-density lipoproteins (HDL) are the major plasma carriers for sphingosine 1-phosphate (S1P) in healthy individuals, but their S1P content is unknown for patients with coronary artery disease (CAD). The aim of the study was to determine whether the S1P levels in plasma and HDL are altered in coronary artery disease. S1P was determined in plasma and HDL isolated by ultracentrifugation from patients with myocardial infarction (MI, n&nbsp;=&nbsp;83), stable CAD (sCAD, n&nbsp;=&nbsp;95), and controls (n&nbsp;=&nbsp;85). In our study, total plasma S1P levels were lower in sCAD than in controls (305 vs. 350&nbsp;pmol/mL). However, normalization to HDL-cholesterol (a known determinant of plasma S1P) revealed higher normalized plasma S1P levels in sCAD than in controls ...
Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes
Conclusions&nbsp;&nbsp;Thiamine administration for 1&nbsp;month decreased glucose and leptin concentrations in drug-naïve patients with T2DM. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00394-010-0123-xAuthors Manuel González-Ortiz, University of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security Cardiovascular Research Unit, Physiology Department, Health Science University Center Montes Urales 1409 44340 Guadalajara, Colonia Independencia MexicoEsperanza Martínez-Abundis, University of Guadalajara and Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medic...
Good Cholesterol Seems Less Important Once Statins Have Lowered Bad Cholesterol
Results of an international trial suggest that once statins have lowered LDL or "bad" cholesterol, the level of HDL or "good" cholesterol is less important in terms of predicting cardiovascular risk than it is during pre-treatment assessment. You can read about the research behind these particular findings from the JUPITER trial in a report published in the early online issue of The Lancet on 22 July... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Cholesterol Study: Low HDL May Not Be So Bad
Title: Cholesterol Study: Low HDL May Not Be So BadCategory: Health NewsCreated: 7/23/2010 11:23:00 AMLast Editorial Review: 7/23/2010 11:23:43 AM (Source: MedicineNet Cholesterol General)
Cholesterol Study: Low HDL May Not Be So Bad
Title: Cholesterol Study: Low HDL May Not Be So BadCategory: Health NewsCreated: 7/23/2010 11:23:00 AMLast Editorial Review: 7/23/2010 11:23:43 AM (Source: MedicineNet Heart General)
Cholesterol Study: Low HDL May Not Be So Bad
Title: Cholesterol Study: Low HDL May Not Be So BadCategory: Health NewsCreated: 7/23/2010 11:23:00 AMLast Editorial Review: 7/23/2010 11:23:43 AM (Source: MedicineNet Senior Health General)
Cholesterol Study: Low HDL May Not Be So Bad
(Source: eMedicineHealth.com)
Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus.
Authors: Kahlon AK, Roy S, Sharma A Dehydrosqualene synthase of Staphylococcus aureus is involved in the synthesis of golden carotenoid pigment staphyloxanthin. This pigment of S. aureus provides the antioxidant property to this bacterium to survive inside the host cell. Dehydrosqualene synthase (CrtM) is having structural similarity with the human squalene synthase enzyme which is involved in the cholesterol synthesis pathway in humans (Liu et al., 2008). Cholesterol lowering drugs were found to have inhibitory effect on dehydrosqualene synthase enzyme of S. aureus. The present study attempts to focus on squalene synthase inhibitors, lapaquistat acetate and squalestatins reported as cholesterol lowering agents in vitro and in vivo but not studied in context to dehydrosqualene synthase...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
(European Society of Cardiology) The European Society of Cardiology is concerned that interpretations of a paper about cholesterol, published in the Lancet, could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol. Caution, the ESC experts advise, should be displayed in the interpretation of the results. (Source: EurekAlert! - Medicine and Health)
Inhibiting fatty acids in immune cells decreases atherosclerosis risk
(Washington University School of Medicine) Scientists at Washington University School of Medicine in St. Louis have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. They did it by interfering with production of a substance called fatty acid synthase, an enzyme that converts dietary sugars into fatty acids in the liver. (Source: EurekAlert! - Medicine and Health)
Inhibiting fatty acids in immune cells decreases atherosclerosis risk
Scientists have found a way to significantly reduce atherosclerosis in mice that does not involve lowering cholesterol levels or eliminating other obesity-related problems. They did it by interfering with production of a substance called fatty acid synthase, an enzyme that converts dietary sugars into fatty acids in the liver. (Source: ScienceDaily Headlines)
No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
The European Society of Cardiology is concerned that interpretations of a paper about cholesterol could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol. Caution, the ESC experts advise, should be displayed in the interpretation of the results. (Source: ScienceDaily Headlines)
The frequency of early, spontaneous miscarriage associates with the leu33pro polymorphism of Glycoprotein IIIa: A pilot study
Conclusions: Our findings indicate that Glycoprotein IIIa leu33pro polymorphism is associated with early, spontaneous miscarriage. The causative role of this polymorphism as risk factor of pregnancy loss needs further investigation by prospective studies. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Angiogenesis and biomarkers of cardiovascular risk in adults with metabolic syndrome
Conclusions. The increase in circulating levels of biomarkers of angiogenesis and cardiac function in subjects with MetSyn mirrors the pathophysiological changes occurring in the cardiovascular system. Over time, these changes might accelerate the formation and progression of atherosclerotic plaques and contribute significantly to cardiovascular morbidity and mortality risk. (Source: Journal of Internal Medicine)
The Collaborative Cardiovascular Risk Reduction in Primary Care (CCARP) Study
Conclusion. This simple cardiovascular care protocol for nonspecialist pharmacists did not result in a clear improvement to cardiovascular risk reduction success among patients in a primary care medical clinic. The intervention did, however, appear to improve statin utilization. (Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy)
Effects of Lipid-Lowering Therapy on Reduction of Cardiovascular Events in Patients with End-Stage Renal Disease Requiring Hemodialysis
Pharmacotherapy 30(8): 823-829 Abstract In the general population, dyslipidemia is an established independent risk factor for cardiovascular disease. In patients with end-stage renal disease (ESRD), comorbid cardiovascular disease is present at alarming rates, and those who require hemodialysis and have cardiovascular disease continue to have a high mortality rate. Lipid abnormalities associated with chronic kidney disease (CKD) vary depending on the stage of disease (stages 1-5), but low-density lipoprotein cholesterol (LDL) has been established as the primary lipid treatment target. Guidelines support an LDL level of less than 100 mg/dl in patients with all stages of CKD, except when the triglyceride level is above 500 mg/dl. As patients progress to stage 5 CKD (ESRD with hemodialysis), ...
Ankle brachial pressure index as a marker of apathy in a community-dwelling population
Apathy is defined as a lack of interest or emotion. Several studies have shown the relationship between apathy and atherosclerotic change in poststroke patients. Although apathy is confused with depression, it might be a specific neuropsychiatric syndrome separate from depression.To clarify the relationship between atherosclerotic change and apathy in a community-dwelling population, which does not include the psychologic factors associated with stroke events.The ankle brachial pressure index (ABI) was measured using a volume-plethymographic apparatus in 860 volunteers (315 males and 545 females) who participated in the Iwaki Health Promotion Project 2008. Starkstein's apathy score and the Center for Epidemiologic Studies Depression Scale (CES-D) were used to assess the psychologic status....
Determinants of paraoxonase activity in healthy adults
Scope: Paraoxonase-1 (PON-1), associated with HDL, is regarded as anti-atherogenic, attributed to its ability to hydrolyze oxidized lipids. Here, the impact of PON and apolipoprotein E genotypes, age, alcohol and HDL-cholesterol (HDL-C) on PON activity is examined. Methods and results: In total, 104 healthy UK adults participated in the study, with basal (PONA) and stimulated (PONB) PON-1 activities and arylesterase activity determined in these individuals. In univariate and correlation analysis age, HDL-C, alcohol intake and both PON genotypes were significantly associated with PONA and PONB activities (p (Source: Molecular Nutrition)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The Impact of Dietary Iodine Intake on Lipid Metabolism in Mice.
In conclusion, dietary iodine intake may affect the metabolism of serum lipids. Hypothyroid function induced by iodine deficiency may be responsible for the changes of lipids. Higher iodine intake might benefit lipid metabolism. PMID: 20652651 [PubMed - as supplied by publisher] (Source: Biological Trace Element Research)
Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism.
Authors: Xiao L, Xie X, Zhai Y Nuclear receptor crosstalk represents an important mechanism to expand the functions of individual receptors. The liver X receptor (LXR, NR1H2/3), both the alpha and beta isoforms, are nuclear receptors that can be activated by the endogenous oxysterols and other synthetic agonists. LXRs function as cholesterol sensors, which protect mammals from cholesterol overload. LXRs have been shown to regulate the expression of a battery of metabolic genes, especially those involved in lipid metabolism. LXRs have recently been suggested to play a novel role in the regulation of drug metabolism. The constitutive androstane receptor (CAR, NR1I3) is a xenobiotic receptor that regulates the expression of drug-metabolizing enzymes and transporters. Disruption of CAR alt...
Effect of Pravastatin on Bleomycin-induced Acute Lung Injury and Pulmonary Fibrosis.
Authors: Kim JW, Rhee CK, Kim TJ, Kim YH, Lee SH, Yoon HK, Kim SC, Lee SY, Kwon SS, Kim KH, Kim YK SUMMARY 1. Pravastatin is best known for its antilipidemic action. Recent studies have demonstrated that statins have immunomodulatory and anti-inflammatory effects. The present study aimed to determine whether or not pravastatin can attenuate acute lung injury and fibrosis in a mouse model. 2. Bleomycin was administrated to C57BL6 mice via intratracheal instillation. Pravastatin was administrated via intraperitoneal injection. To study the effect of pravastatin on the early inflammatory phase and the late fibrotic phase, mice were sacrificed on days 3, 7, 14 and 21. 3. Pravastatin attenuated the histopathologic change of bleomycin-induced lung injury and fibrosis. The accumulation of neu...
Half of Young Adults Have CHD Risk Factors
Although half of young adults have at least one CHD risk factor, less than 50%, irrespective of cardiovascular risk status, are screened for high cholesterol levels. Heartwire (Source: Medscape Today Headlines)
Half of young adults have CHD risk factors
Although half of young adults have at least one CHD risk factor, less than 50%, irrespective of cardiovascular risk status, are screened for high cholesterol levels. For complete story visit theheart.org. (Source: theHeart.org)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
HDL Loses Power After LDL Lowering (CME/CE)
The predictive value of HDL cholesterol all but disappeared with treatment-induced low levels of LDL, according to a new analysis of data from a large trial of lipid-lowering therapy. (Source: MedPage Today Cardiovascular)
Some on Statins May Not Need Boost in ?Good? Cholesterol
High-dose users with very low 'bad' cholesterol don't benefit, researchers say (Source: The Doctors Lounge - Cardiology)
Some on Statins May Not Need Boost in 'Good' Cholesterol
High-dose users with very low 'bad' cholesterol don't benefit, researchers say (Source: U.S. News - Health)
New Links Between Cholesterol And Depression In The Elderly
Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one's risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. However, new findings by French researchers, published in Biological Psychiatry, suggest the link between increased cholesterol and depression may be complicated... (Source: Health News from Medical News Today)
+294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians.
Authors: Jguirim-Souissi I, Jelassi A, Hrira Y, Najah M, Slimani A, Addad F, Hassine M, Hamda KB, Maatouk F, Rouis M, Slimane MN Peroxisome proliferator-activated receptor delta (PPAR-delta) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we investigated a possible association of this polymorphism with plasma lipid and lipoprotein levels and with risk and outcome of CAD in a normolipidemic Tunisian population. Genotyping was performed by PCR-RFLP in 112 CAD patients and 113 healthy volunteers. The C-allele was ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Antioxidants help arteries stay healthy in people at risk for heart disease
(NaturalNews) Antioxidants are substances that protect cells against the effects of free radicals -- molecules produced when the body breaks down food or is exposed to environmental toxins and radiation. Free radicals are believed to play a role in heart disease, cancer and other disorders. So it makes sense that antioxidants could help protect or even treat many health problems. However, some poorly designed studies have given antioxidants mixed results (http://www.naturalnews.com/023357_pharmas_antioxidants_vitamins.html) and resulted in the mainstream media reporting that antioxidants are virtually worthless. But new research provides hard evidence that taking antioxidant supplements long-term produces dramatic benefits in people with multiple cardiovascular risk factors.That's the conc...
Can Ozone Cause Heart Attacks?
Title: Can Ozone Cause Heart Attacks?Category: Health NewsCreated: 7/22/2010 8:10:00 AMLast Editorial Review: 7/22/2010 (Source: MedicineNet Cholesterol General)
Some on Statins May Not Need Boost in 'Good' Cholesterol
Title: Some on Statins May Not Need Boost in 'Good' CholesterolCategory: Health NewsCreated: 7/22/2010 8:10:00 AMLast Editorial Review: 7/22/2010 (Source: MedicineNet Cholesterol General)
Some on Statins May Not Need Boost in 'Good' Cholesterol
Title: Some on Statins May Not Need Boost in 'Good' CholesterolCategory: Health NewsCreated: 7/22/2010 8:10:00 AMLast Editorial Review: 7/22/2010 (Source: MedicineNet Heart General)
Some on Statins May Not Need Boost in 'Good' Cholesterol
Title: Some on Statins May Not Need Boost in 'Good' CholesterolCategory: Health NewsCreated: 7/22/2010 8:10:00 AMLast Editorial Review: 7/22/2010 (Source: MedicineNet Senior Health General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Administration Announces Regulations Requiring New Health Insurance Plans to Provide Free Preventive Care
July 20, 2010 - The Departments of Health and Human Services (HHS), Labor, and the Treasury issued new regulations, requiring new private health plans to cover evidence-based preventive services and eliminate cost sharing requirements for such services.  The new rules will help Americans gain easier access to services such as blood pressure, diabetes, and cholesterol tests; many cancer screenings; routine vaccinations; pre-natal care; and regular wellness visits for infants and children. (Source: NurseZone.com Nursing News)
Combination Therapy With Prescription Omega-3-Acid Ethyl Esters and Statin Improves Non-HDL-C More Effectively Than Statin Alone
Synergistic effects on dyslipidemia by a dynamic-drug-duo are discussed. Clinical Lipidology (Source: Medscape Cardiology Headlines)
Cholesterol Study: Low HDL May Not Be So Bad
Patients on statin drugs who reduce their LDL ''bad'' cholesterol to very low levels may not need to be so concerned about boosting their HDL ''good" cholesterol levels for protection against cardiovascular disease, according to a new study. (Source: WebMD Health)
Your 'good' cholesterol helps keep heart healthy
A high HDL cholesterol level helps fight heart disease. Here's how to raise your HDL. (Source: MayoClinic.com Full Feed)
Good cholesterol may mean little for statin users
CHICAGO (Reuters) - People with high levels of the so-called good cholesterol HDL tend to have fewer heart attacks but HDL may offer little protective benefit in people who take statins to lower harmful LDL cholesterol, U.S. researchers said on Wednesday. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Effects of aerobic and strength-based training on metabolic health indicators in older adults
Conclusion: The training programs produced significant benefits on metabolic health indicators of sedentary older women and men. (Source: BioMed Central)
HDL-cholesterol levels no longer predictive of risk in intensively statin-treated patients?
Source: Lancet Area: News Analysis of data from the JUPITER study indicated that in patients treated with rosuvastatin to achieve very low LDL-cholesterol levels, the level of HDL-cholesterol was no longer predictive of cardiovascular risk. &nbsp; The JUPITER primary prevention study randomised patients with no previous history of cardiovascular disease and no diabetes to treatment with rosuvastatin 20mg daily or placebo. The primary outcome of the trial was a composite of first non-fatal myocardial infarction or stroke, hospitalisation for unstable angina, arterial revascularisation, or cardiovascular death: this analysis examined whether there was an association between HDL-cholesterol levels and the rate of the primary outcome in the two study groups. &nbsp; There were 17,802 p...
Effectiveness of staged diabetes management on the quality of diabetes care in Mexico
The aim of this study was to investigate the effectiveness of staged diabetes management, a structured programme developed by the International Diabetes Center in Minneapolis, USA, on the quality of outpatient diabetes care at the primary level in Mexico.A prospective study was conducted in patients treated at outpatient diabetes clinics established in public health centres in 2001-2007 in Hidalgo, Mexico. Diabetes care was provided by multidisciplinary teams which included general physicians and nurses as a minimum. Organisational arrangements were made to reduce waiting times, avoid rotation of staff, and provide adequate time for baseline and follow-up visits. Process and outcomes indicators of quality of diabetes care included body mass index, blood pressure, fasting/casual blood gluco...
When LDL After Statin is Very Low, HDL Not a Risk Factor
Low high-density lipoprotein levels are associated with increased cardiovascular risk in patients untreated by statins, but in treated patients who achieve very low low-density lipoprotein levels, high-density lipoprotein level is no longer associated with level of risk, according to research published online July 22 in The Lancet. (Source: Modern Medicine)
Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid [beta]-peptide accumulation
To test the hypothesis that narrowing of cranial blood vessels in cholesterol-fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk.Four groups of New Zealand White rabbits were studied. Six were fed a normal diet, 19 were fed a 2% cholesterol diet with 0.12 ppm copper in the drinking water for 8 weeks, 10 weeks, or 12 weeks. Time-of-flight (TOF) MR angiography (MRA) at 3 Tesla was used to measure arterial diameters in 11 vessels. Previously published data for amyloid [beta]-peptide (A[beta]) accumulation in the brains measured postmortem were correlated to vessel diameters. Ventricular volumes of rabbits were measured on group-averaged data.Several vessel d...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Effect of Ezetimibe on Incretin Secretion in Response to the Intestinal Absorption of a Mixed Meal.
Authors: Yang L, Li X, Ji Y, Kohan AB, Wang DQ, Howles PN, Hui DY, Lai J, Tso P Ezetimibe is a potent inhibitor of cholesterol absorption by enterocytes. Although ezetimibe minimally affects the absorption of triglyceride, it is unknown if ezetimibe affects the secretion of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). It has been shown that ezetimibe-treated mice are protected from diet-induced insulin resistance. Since GIP and GLP-1 promote the actions of insulin, we hypothesized that ezetimibe may affect the secretion of GIP and GLP-1 by enteroendocrine cells into lymph in response to the intestinal absorption of a mixed meal (Ensure(R)). To test this hypothesis, we used the lymph fistula rat model to determine GIP and ...
Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success.
Authors: Steenbergen RH, Joyce MA, Lund G, Lewis J, Chen R, Barsby N, Zhu LF, Tyrrell L, Kneteman NM Although multiple determinants for HCV infection are known, it remains partly unclear what determines the human specificity of HCV infection Presumably, the presence of appropriate entry receptors is essential, and this may explain why HCV is unable to infect non-human hepatocytes. However, using mice with chimeric human livers, we show in this study that the presence of human hepatocytes, and therefore human entry receptors, is not sufficient for HCV infection. In successfully transplanted SCID/Alb-uPA mice, infection with HCV is only reliable when ~70-80% of the liver consists of human hepatocytes. We show that chimeric mice, which are hard to infect with HCV, have significant groups ...
Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT is Upregulated in Rats with Diabetes Mellitus Induced by Low-Doses of Streptozotocin.
Authors: Annaba F, Ma K, Kumar P, Dudeja AK, Kineman RD, Shneider BL, Saksena S, Gill RK, Alrefai WA Increased intestinal bile acid absorption and expansion of the bile acid pool has been implicated in the hypercholesterolemia associated with diabetes mellitus. However, the molecular basis of the increase in bile acid absorption in diabetes mellitus is not fully understood. The ileal Apical Sodium-Dependent Bile Acid Transporter (ASBT) is primarily responsible for active reabsorption of majority of bile acids. Current studies were designed to investigate the modulation of ASBT function and expression in streptozotocin (stz)-induced diabetes mellitus in rats and to examine the effect of insulin on rat ASBT promoter by insulin. Diabetes mellitus was induced in Sprague-Dawley rats by intr...
TRAF5 Deficiency Accelerates Atherogenesis in Mice by Increasing Inflammatory Cell Recruitment and Foam Cell Formation.
Conclusions: Unexpectedly, TRAF5 deficiency accelerates atherogenesis in mice, an effect likely mediated by increased inflammatory cell recruitment to the vessel wall and enhanced foam cell formation. PMID: 20651286 [PubMed - as supplied by publisher] (Source: Circulation Research)
Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats.
Authors: Birari R, Javia V, Bhutani KK The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300mg/kg/day to the high fat diet (HFD) induced obese rats for two weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity. PMID: 20655993 [PubMed - as supplied by publisher] (Source: Fitoterapia)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
More from JUPITER: HDL not predictive of risk at very low LDL levels
A new post hoc analysis of the JUPITER trial has shown that when patients have very low concentrations of LDL cholesterol attained through the use of potent statin therapy, "good" HDL cholesterol may... For complete story visit theheart.org. (Source: theHeart.org)
Good Cholesterol May Mean Little for Statin Users
People with high levels of the so-called good cholesterol HDL tend to have fewer heart attacks but HDL may offer little protective benefit in people who take statins to lower harmful LDL cholesterol, U.S. researchers said on Wednesday.Source: Reuters Health Related MedlinePlus Pages: Cholesterol, Heart Attack, Statins (Source: MedlinePlus Health News)
New Links Between Cholesterol and Depression in the Elderly
July 21, 2010 (EurekAlert) - Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one's risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. read more (Source: Diabetes News from dLife.com)
New Links Between Cholesterol and Depression in the Elderly
July 21, 2010 (EurekAlert) - Most people know that high cholesterol levels place them at increased risk for heart disease and stroke. Prior research has shown that particular types of strokes contribute to one's risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. read more (Source: Diabetes News from dLife.com)
Highly Sensitive Fluorescent Method for the Detection of Cholesterol Aldehydes Formed by Ozone and Singlet Molecular Oxygen
Analytical Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Analytical Chemistry)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Lancet: HDL cholesterol in statin takers not predictive of CV risk
Among patients on high-doses of statin therapy who achieve low levels of LDL cholesterol, HDL cholesterol concentrations are not predictive of cardiovascular risk, according to a sub-study of the JUPITER trial published July 21 in the Lancet. (Source: Cardiovascular Business News)
Acyl-Chain Mismatch Driven Superlattice Arrangements in DPPC/DLPC/Cholesterol Bilayers
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Physical Chemistry B)
Statins and cholesterol
Boosting 'good' cholesterol is always good for your heart health (Source: BHF National News)
You?re Better Off Eating a Cardboard Box
Dear Health Conscious Reader, The other day G.S. came to my office for a visit. I won?t get into his personal medical issue, but the subject of fiber came up. He said, ?Dr. Sears, I?m getting all the fiber I need. Every morning I have my whole wheat toast or a big bowl of Frosted Mini-Wheats.? I?m telling you this because it?s kind of typical. My patients believe they?re getting the right kind of fiber from whole grains. The truth is all fiber is not created equal. You could call a cardboard box ?fiber,? because it?s cellulose and your body wouldn?t digest it. But it?s not the type of fiber nature intended for you to have in your body. There are different types of fiber. Some are natural to your diet, and others ? like the fibers you get from grains ? are not na...
Statin-treated dyslipidemia patients ?often not at goal?
A significant proportion of high-risk dyslipidemic individuals are not achieving their treatment goals despite using statins, a French team has found. (Source: MedWire News - Lipidology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Procedure Rejuvenates Aging Arteries in Pigs
Title: Procedure Rejuvenates Aging Arteries in PigsCategory: Health NewsCreated: 7/21/2010 8:10:00 AMLast Editorial Review: 7/21/2010 (Source: MedicineNet Cholesterol General)
Administration Announces Regulations Requiring New...
July 20, 2010 - The Departments of Health and Human Services (HHS), Labor, and the Treasury issued new regulations, requiring new private health plans to cover evidence-based preventive services and eliminate cost sharing requirements for such services.  The new rules will help Americans gain easier access to services such as blood pressure, diabetes, and cholesterol tests; many cancer screenings; routine vaccinations; pre-natal care; and regular wellness visits for infants and children. (Source: NurseZone.com Nursing News)
All Red Yeast Rice Products Are Not Created Equal?or Legal
Discussion? section ends with the recommendation ?Producing red yeast rice under controlled conditions could provide a widely available and safe dietary supplement for lowering cholesterol.? (Source: The American Journal of Cardiology)
Comparison of Atorvastatin 80 mg/day Versus Simvastatin 20 to 40 mg/day on Frequency of Cardiovascular Events Late (Five Years) After Acute Myocardial Infarction (from the Incremental Decrease in End Points Through Aggressive Lipid Lowering [IDEAL] Trial)
Previous studies have demonstrated that benefits of intensive statin therapy compared to standard statin therapy begin shortly after an acute event and are continued up to 2 years of follow-up. However, whether efficacy and safety of intensive statin therapy in patients with a recent cardiac event are maintained in longer-term follow-up has not been evaluated. We conducted a post hoc analysis of a subgroup of 999 patients who had a first acute myocardial infarction (MI) (Source: The American Journal of Cardiology)
New links between cholesterol and depression in the elderly
(Elsevier) Prior research has shown that particular types of strokes contribute to one's risk for depression, and that abnormal blood lipid levels can increase the risk of depression in the elderly. However, new findings by French researchers, published in Biological Psychiatry, suggest the link between increased cholesterol and depression may be complicated. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Addressing modifiable risk factors for coronary heart disease in primary care: an evidence-base lost in translation
Conclusions. There appears to be an evidence-base lost in translation. Different guidelines calculate risk differently, and even when the same guideline is used, variation in implementation leads to further variation. Education and development of improved risk calculators should enable the most appropriate calculator to be used for an individual patient; accreditation of implementation could be achieved through the use of a standard set of test cases. (Source: Family Practice)
Reductions in risk factors for secondary prevention of coronary heart disease by ethnic group in south-west London: 10-year longitudinal study (1998-2007)
Conclusions. From 1998 to 2007, risk factor control among patients with CHD improved, with reductions in their mean blood pressure and cholesterol across all ethnic groups. Widespread policy change has helped to improve the quality and equity of primary care for heart disease patients. Health improvements predated implementation of the Quality and Outcomes Framework and have since continued. Our findings illustrate how a national health care system with universal coverage can significantly reduce inequalities and improve chronic disease care for all ethnic groups. (Source: Family Practice)
Differences in the primary care management of patients with psychosis from two ethnic groups: a population-based cross-sectional study
Conclusions. Measurable aspects of physical health care of patients with psychosis were similar, regardless of ethnicity. Increased use of the depot antipsychotic medication in black patients needs further exploration. (Source: Family Practice)
Statin use lowers after gastric bypass surgery
Long-term data from a retrospective cohort study showed that hyperlipidemic obese patients had more than a 90% reduction in their need of lipid-lowering therapy following laparoscopic gastric-bypass surgery, MedPage Today reported. (Source: Drug Topics - Top News)
Synergistic Activation of the Mc2r Promoter by FOXL2 and NR5A1 in Mice.
Authors: Yang WH, Gutierrez N, Wang L, Ellsworth BS, Wang CM FOXL2 is the earliest ovarian marker and plays an important role in regulation of cholesterol and steroid metabolism, inflammation, apoptosis, and ovarian development and function. Mutations and deficiencies of the human FOXL2 gene have been shown to cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) as well as premature ovarian failure. Although Foxl2 interacts with Nr5a1 and up-regulates cyp19a1a gene transcription in fish, FOXL2 represses the transcriptional activity of the gene that codes for steroidogenic acute regulatory protein (Star) in mice. Most of the recent studies have heavily focused on the FOXL2 target genes (Star and Cyp19a1) in the ovaries. Hence, it is of importance to search for other downstr...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Nuclear Receptors as Drug Targets for Metabolic Disease.
Authors: Schulman IG Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiation, and homeostasis. Over the last 15years a growing number of nuclear receptors have been identified that coordinate genetic networks regulating lipid metabolism and energy utilization. Several of these receptors directly sample the levels of metabolic intermediates including fatty acids and cholesterol derivatives and use this information to regulate the synthesis, transport, and breakdown of the metabolite of interest. In contrast, other family members sense metabolic activity via the presence or absence of interacting proteins. The ability of these nuclear receptors to impact metabolism will be discussed and the challenges facing dru...
Organic Cation Transporter 1 Polymorphisms Predict the Metabolic Response to Metformin in Women with the Polycystic Ovary Syndrome.
Conclusions: Genetic variation in OCT1 may be associated with heterogeneity in the metabolic response to metformin in women with PCOS. PMID: 20660041 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
New Treasure From Old Trials for Seniors and Obese Patients
Henry Black, MD, looks at new results from PROGESS and JUPITER, which report on treating hypertensive obese patients and statins for older patients with elevated CRP and low LDL-C. Medscape Cardiology (Source: Medscape Today Headlines)
Calculation of the benchmark duration of shift work associated with the development of impaired glucose metabolism: a 14-year cohort study on 7104 male workers
Conclusion These results suggest that special attention should be paid to middle-aged workers whose years of shift work exceeds these threshold times. (Source: Occupational and Environmental Medicine)
Cochrane review finds statin therapy effective in children with FH
Statin therapy is effective for lowering lipid levels in children with familial hypercholesterolemia, a Cochrane review has found. (Source: MedWire News - Lipidology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Quality of US Primary Care Delivered by Resident and Staff Physicians
Conclusions&nbsp;&nbsp;Primary care provided by resident physicians is of similar or higher quality than that provided by staff physicians. Significant opportunity remains to improve quality of outpatient care provided by all physicians. Residency training programs should devote attention to improving outpatient quality of care delivered by residents. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s11606-010-1456-0Authors Leah Zallman, Department of Medicine, Cambridge Health Alliance and Harvard Medical School Cambridge MA USAJun Ma, Palo Alto Medical Foundation Research Institute Palo Alto CA USALan Xiao, Palo Alto Medical Foundation Research Institute Palo Alto CA USAKaren E. Lasser, Boston Medical Center Section of General Internal Medicine 801 Massachus...
Ecklonia Cava: Brown Algae for Better Health?
I received literature in the mail promoting Ecklonia cava as a supplement for high blood pressure, high cholesterol, and as an antioxidant.&nbsp;Is there any evidence that this supplement can help in all of these areas?&nbsp; (Source: Dr. Weil Q and A)
Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin ? JUPITER Controversy A Critical Reappraisal
This article critically reviews the trial JUPITER which reported a substantial decrease in the risk of cardiovascular diseases among patients without coronary heart disease and with normal or low cholesterol levels. Concern was expressed that the trial was flawed as it was discontinued (according to prespecified rules) after fewer than 2 years of follow-up, with no differences between the 2 groups on the most objective criteria. The authors concluded that the results of the trial do not support the use of statin treatment for primary prevention of cardiovascular diseases, while raising concerning questions about the role of commercial sponsors. : Systematic Review: Vitamin D and Calcium Supplementation in Prevention of Cardiovascular Events Renal outcomes with different fixed-dose combina...
Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.
In conclusion, Sim and Lov both seem to reverse mesangial cell hypocontractility. The process of Sim reversal of mesangial cell hypocontractility may involve F-actin, TCP-1beta, and GRP78. PMID: 20627192 [PubMed - in process] (Source: Translational Research : the journal of laboratory and clinical medicine)

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