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Lower Your Cholesterol With These Foods
By Dr John
High blood cholesterol problem may lead to the critical complicationssuch as cardiac problems that may prove to be fatal in the due courseof time. You may have high blood cholesterol due to several Read more...
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What is Cholesterol?
About Your CholesterolCholesterol
is a type of fat and is part of all animal cells. It is
essential for many of your body’s metabolic processes, including
production and it helps the body use vitamin D.
The body is very good
at making its own cholesterol; you don’t need to help it along. In
fact, too much cholesterol in your diet can lead to heart disease.
Cholesterol is found in all cell
membranes and it is transported around the body via the plasma in your
blood. Trace amounts of cholesterol are also found in membranes of
plants and fungi. Cholesterol
is a combination steroid and alcohol, the name Cholesterol originates
from the Greek chole- (bile) and stereos (solid), and the chemical
suffix -ol for an alcohol.
 |
Most
of our cholesterol is created naturally by the body and some has its
origin in our diet. Cholesterol is more abundant in the tissues of the
liver, the spinal cord and the brain and plays a central role in many
biochemical processes important to a healthy body. Abnormally
high cholesterol levels (hypercholesterolemia) and abnormal proportions
of LDL and HDL are associated with cardiovascular disease by promoting
atheroma development in arteries (atherosclerosis).
|
This
disease process leads to heart attack (myocardial infarction), stroke
and peripheral vascular disease. As high LDL contributes to this
process, it is termed "bad cholesterol", while high levels of HDL
("good cholesterol") offer a degree of protection. The balance can be
redressed with exercise, a healthy diet, and sometimes medication.
We strive to provide only quality articles and
other resources, so if there is a specific topic related to
cholesterol that you would like us to cover, please contact us at
any time.
And again, thank you to those contributing daily to
our cholesterol website.
TheTeam@awareness-guide.com
Thanks
For Stopping by...
Should Statin Therapy Be Allocated on the Basis of Global Risk or on the Basis of Randomized Trial Evidence?
In conclusion, the authors propose an alternative approach for incorporating more recent randomized trial data into future statin allocation algorithms and treatment guidelines. (Source: The American Journal of Cardiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Tight blood pressure control can save kidneys
Kidney function preserved in black people with proteinurea by aggressive BP loweringRelated items from OnMedicaBenefits of statins 'still outweigh risks'Bowel disease raises risk of blood clots threefoldRisk/benefit balance of alteplase shifts quicklyConsider statins for patients at risk of clotHigh salt intake strongly linked to stroke and CVD (Source: OnMedica Latest News)
The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse
In conclusion, in the diabetic Apo-E–/– mouse, rosuvastatin confers renal benefits that are independent of lipid lowering and equivalent or greater to those observed with candesartan. The combination treatment is not superior to monotherapies. (Source: AJP: Renal Physiology)
September Is National Cholesterol Education Month
Source: Centers for Disease Control and Prevention
Related MedlinePlus Page: Cholesterol (Source: MedlinePlus Health News)
Importance of a balanced diet on the physical fitness level of schoolchildren aged 6-12
This article explores the integrated effect of nine nutrients on an individual’s physical fitness level. Two-day dietary records and physical fitness assessments were collected in three primary schools. Cluster analysis allowed compliance with nutrient recommendations to be compared among groups of primary school students with different characteristics. Two clusters were identified statistically. Cluster B, which comprised more schoolchildren at the ‘Good’ and ‘Pass’ levels and fewer at the ‘Excellent’ level, had significantly more participants who met the guidelines for total fat, saturated fat, sodium and cholesterol, compared with Cluster A. This finding reveals the benefits of a balanced diet, with physical fitness level as the outcome measure....
Rosuvastatin-Induced Thrombocytopenia
Since thrombocytopenia can have many different causes, statin therapy might easily have been overlooked as the precipitating factor in this patient taking Rosuvastatin. Southern Medical Journal (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
ESC: Pre-Procedure Statins May Cut MI Risk (CME/CE)
STOCKHOLM (MedPage Today) -- Statins delivered before invasive procedures appear to reduce the occurrence of cardiovascular events, a meta-analysis showed. (Source: MedPage Today Cardiovascular)
Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model.
Conclusion:
The presence of metabolic syndrome in patients with hypertension significantly inflates economic burden and costs are likely to increase in the future due to an aging population and an increase in the prevalence of components of metabolic syndrome. (Source: BMC Public Health - Latest articles)
ESC: Statins Do Not Raise Cancer Rates and Mortality
Statin therapy does not appear to be associated with increased cancer rates and mortality, according
to research presented at the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in Stockholm,
Sweden. (Source: Modern Medicine)
ESC: With MI, Non-Cardiac Surgery, Statins Lower MI Risk
Administration of a pre-procedural statin drug significantly reduces myocardial infarction after both
percutaneous coronary intervention and non-cardiac surgery, and also lowers the risk of atrial fibrillation after
coronary artery bypass grafting, according to research published online Aug. 30 in the Journal of the American
College of Cardiology to coincide with the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in
Stockholm, Sweden. (Source: Modern Medicine)
Statins in women for primary prevention - is there evidence to back up their use??
Authors: Fenton A, Panay N
PMID: 20738236 [PubMed - in process] (Source: Climacteric)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Balanced diet cuts heart risk
Conclusion
This well-conducted trial benefits from its relatively large size, accurate provision of the three randomised diets and high study completion rates (95%). It also featured a reliable study outcome by using the average of a series of blood pressure measures, which is preferable to relying on a single blood pressure reading.
The study found that eight weeks of the DASH diet, which was rich in fruit and vegetables and low in saturated fat, lowered blood pressure and cholesterol. This contributed to a decrease in predicted 10-year CHD risk. The DASH diet reduced this risk by 18% compared to a high-saturated fat ?American? diet and by 11% compared to a diet similar to the American diet but with higher intake of fruit and vegetables.
Some points to note when interpreting this stud...
Findings of a U.S. National Cardiometabolic Screening Program Among 10,084 Psychiatric Outpatients [Articles]
CONCLUSIONS: The prevalence of metabolic syndrome and cardiometabolic risk factors, such as overweight, hypertension, dyslipidemia, and glucose abnormalities, was substantial and frequently untreated in this U.S. national mental health clinic screening program. (Source: Psychiatr Serv)
Data From Mipomersen Phase 3 Trial In heFH Patients Presented At ESC
Genzyme Corp. (NASDAQ: GENZ) and Isis Pharmaceuticals Inc. (NASDAQ: ISIS) announced that data from the phase 3 study of mipomersen in patients with heterozygous familial hypercholesterolemia (heFH) were presented at the European Society of Cardiology's Congress 2010 in Stockholm, Sweden. The study met its primary endpoint with a 28 percent reduction in LDL-cholesterol, compared with an increase of 5 percent for placebo (pThis double-blind, placebo-controlled phase 3 study was designed to test the efficacy and safety of adding mipomersen to stable lipid-lowering therapy... (Source: Health News from Medical News Today)
Heart news digest
Statins and cancer, insomnia, crisps and father and son's 'end to end' cycle ride (Source: BHF National News)
Separating the Contribution of Glucocorticoids and Wakefulness to the Molecular and Electrophysiological Correlates of Sleep Homeostasis
Conclusions: Our findings indicate that corticosterone contributes to the sleep-deprivation–induced changes in brain transcriptome that have been attributed to wakefulness per se. The study identified 78 transcripts that respond to sleep loss independent of corticosterone and time of day, among which genes involved in neuroprotection prominently feature, pointing to a molecular pathway directly relevant for sleep function.
Keywords: Sleep regulation, corticosterone, neuroprotection, microarray, microRNA (Source: Sleep)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
DASH Eating Plan Lowers Long-Term Heart Attack Risk, Especially Among African-Americans
The DASH eating plan, known to reduce blood pressure and bad cholesterol, also reduces the 10-year risk of heart attack, especially among African-Americans, according to research reported in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. The DASH eating plan emphasizes fruits, vegetables and low-fat dairy products as well as whole grains, poultry, fish and nuts. The plan also calls for a reduction in fats, red meat, sweets, and sugar-containing beverages. It is recommended by the U.S. government and American Heart Association... (Source: Health News from Medical News Today)
Simplifying cardiovascular risk estimation using resting heart rate
Conclusion
Addition of RHR to formulas already containing lipid and blood pressure measures does not appreciably improve risk estimation. However, inclusion of RHR in simple systems, which can potentially enhance cost-effectiveness and accessibility of risk estimation, is useful. (Source: European Heart Journal)
Netherlands Study Shows Need For Dose Management Care When Switching To Generic Statins
Research conducted in the Netherlands has highlighted the need for care when switching patients under treatment for high cholesterol from branded to generic drug families. The study shows that much of the switching can result in patients inadvertently receiving non-equivalent doses, potentially leading to an increased risk of downstream heart disease and stroke. Guidelines have been issued by many national healthcare providers to switch patients away from more expensive branded versions of drugs... (Source: Health News from Medical News Today)
Review Finds No Statin-Cancer Link
Title: Review Finds No Statin-Cancer LinkCategory: Health NewsCreated: 8/31/2010 12:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cancer General)
Review Finds No Statin-Cancer Link
Title: Review Finds No Statin-Cancer LinkCategory: Health NewsCreated: 8/31/2010 12:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cholesterol General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
'DASH Diet' Shown to Lower Heart Attack Risk Almost 20%
Title: 'DASH Diet' Shown to Lower Heart Attack Risk Almost 20%Category: Health NewsCreated: 8/31/2010 4:10:00 PMLast Editorial Review: 9/1/2010 (Source: MedicineNet Cholesterol General)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find (Source: Cancercompass News: Other Cancer)
Atherogenic dyslipidemia commonly found with stable coronary disease
A significant proportion of patients with coronary artery disease could benefit from efforts to increase their high-density lipoprotein cholesterol levels and reduce triglycerides, researchers say. (Source: MedWire News - Lipidology)
Editorial - Effect of statins on serum prostate-specific antigen levels
BERKELEY, CA (UroToday.com) - In the online edition of the... (Source: UroToday)
Beyond statin therapy: a review of the management of residual risk in diabetes mellitus
This article will review dyslipidaemia and its role in DM, and will discuss available treatment modalities that address residual cardiovascular risk in this disease. (Source: JRSM)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Angina pill reduces CV death risk for heart failure patients
Ivabradine cut risk of CV death/hospitalisation from heart failure by 18%Related items from OnMedicaIgnored cholesterol blamed for heart attacksHospitals fail women with myocardial infarctionPoor patients more likely to die after heart surgery than richPolypill could halve cardiovascular events NICE should adopt new risk score for heart disease (Source: OnMedica Latest News)
Intracellular molecular effects of insulin resistance in patients with metabolic syndrome
Conclusions In patients with MetS, we found a reduction of mTOR and other mTOR-related molecules involved in insulin resistance, cell repair, coagulation and vasculogenesis. A reduced expression of mTOR may reflect an increased risk of vascular thrombosis. (Source: Cardiovascular Diabetology)
Effects of a sphingolipid-enriched dairy formulation on postprandial lipid concentrations
Authors: L Ohlsson, H Burling, R-D Duan
& Å Nilsson (Source: European Journal of Clinical Nutrition)
The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial
Authors: X Lin, S B Racette, M Lefevre, C A Spearie, M Most, L Ma
& R E Ostlund (Source: European Journal of Clinical Nutrition)
The Effect of Nitric Oxide and Statins on Thrombospondin-1-Induced Chemotaxis in Vascular Smooth Muscle Cells
Vascular smooth muscle cell (VSMC) chemotaxis is important in intimal hyperplasia (IH). Nitric oxide (NO), a diffusible molecule that decreases VSMC chemotaxis to several growth factors, is protective against IH. Thrombospondin-1 (TSP-1), a matricellular glycoprotein that induces VSMC chemotaxis, acts antagonistically to NO in VSMCs. Statins exhibit direct and pleiotropic effects on VSMCs. We showed overnight treatment with lovastatin inhibited TSP-1-induced VSMC chemotaxis by mevalonate pathway inhibition and was Ras dependent. Hypothesis: Short-term statin treatment will inhibit TSP-1-induced VSMC chemotaxis and NO donors will enhance statin inhibitory effects. (Source: Journal of Vascular Surgery)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Regarding ?Preoperative statin therapy is associated with improved outcomes and resource utilization in patients undergoing aortic aneurysm repair?
McNally et al demonstrated, in their retrospective analysis of 401 patients undergoing elective abdominal aortic aneurysm repair, that postoperative mortality rate was significantly decreased in the open repair statin cohort compared with the nonstatin open repair cohort and trended to be decreased in the endovascular repair statin group. Previous meta-analyses, which combined unadjusted odds ratios (ORs) in nonrandomized studies, also suggested that preoperative statin therapy was associated with lower postoperative mortality after vascular surgery. Since these meta-analyses were conducted, however, results of a number of controlled studies have been reported to date. In the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography III (DECREASE III) trial, a recent...
Reply
We read the comments from Takagi et al with great interest. Their letter outlines an interesting and thought-provoking meta-analysis demonstrating the protective benefits of preoperative statin therapy in patients with noncoronary vascular disease. In addition to the studies cited in our manuscript, this letter cites several other important sources which add credence to our hypothesis regarding the influence of statin-class drugs on operative outcomes and resource utilization after aneurysm surgery. Takagi et al should be commended for this analysis, and we would urge the authors to consider a robust publication of the methodology and data. (Source: Journal of Vascular Surgery)
Major study finds no evidence that statins cause cancer
In the largest and most reliable study of its type, researchers in the UK and Australia have demonstrated that statin therapy is not a cause of increased cancer rates and deaths. (Source: ScienceDaily Headlines)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find (Source: The Doctors Lounge - Cardiology)
Review Finds No Statin-Cancer Link
Cancer death rates in 26 trials the same as those taking a placebo, researchers find
Source: HealthDay
Related MedlinePlus Pages: Cancer, Statins (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Statins and cancer
Statins do not raise risk of cancer (Source: BHF National News)
pH-Sensitive mPEG-Hz-Cholesterol Conjugates as a Liposome Delivery System
Hydrazone (Hz)-based pH-sensitive methoxy(polyethylene glycol)-cholesterol conjugates (mPEG-Hz-Chol), were synthesized and used to fabricate liposomes. The structures of the mPEG2000-Hz-Chol conjugate were confirmed by FT-IR and 1H-NMR; they were stable at pH 7.4 but sensitive to mild acid conditions (pH 5.5). Plain liposomes were also prepared with S100PC/ Chol, and the pH-insensitive liposomes with S100PC/Chol/mPEG2000-Chol for comparison; all the liposomes were similar in diameter ~200 nm. In vitro, the pH-sensitive liposomes released more of the model drug, paclitaxel (PTX), than the plain liposomes. The pH-sensitive liposomes were less toxic than the plain liposomes and exhibited higher cellular uptake of PTX compared with pH-insensitive liposomes by human breast cancer cells (MCF-7)....
Prediction of Response to Pegylated Interferon plus Ribavirin by IL28B Gene Variation in Patients Coinfected With HIV and Hepatitis C Virus
Conclusions.?IL28B gene variations independently predict SVR in HIV/HCV?coinfected patients with HCV genotype 1 and non?genotype 1 HCV infection. The association between rs12979860 and plasma low?density lipoprotein cholesterol suggests that the system low?density lipoprotein ligand/receptor might be involved in the effect of this genotype. (Source: Clinical Infectious Diseases Latest Issue)
Clues to Heart Attack, Stroke Risk From Fat-Filled Artery
Title: Clues to Heart Attack, Stroke Risk From Fat-Filled ArteryCategory: Health NewsCreated: 8/30/2010 10:10:00 AMLast Editorial Review: 8/31/2010 (Source: MedicineNet Cholesterol General)
CTT Meta-Analysis: No Cancer Risk With Statins, Low LDL-Cholesterol Levels
Investigators report that statin therapy had no adverse effect on any cancer type, irrespective of how long patients took the cholesterol-lowering medications or their baseline LDL-cholesterol levels. Heartwire (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Measuring quality of diabetes care by linking health care system administrative databases with laboratory data
Background:
Chronic complications of diabetes can be reduced through optimal glycemic and lipid control as evaluated through measurement of glycosylated hemoglobin (A1C) and low-density lipoprotein cholesterol (LDL-C). We aimed to produce measures of quality of diabetes care in Saskatchewan and to identify sub-groups at particular risk of developing complications.FindingsPrevalent adult cases of diabetes in 2005/06 were identified from administrative databases and linked with A1C and LDL-C tests measured in centralized laboratories. A1C results were performed in 33,927 of 50,713 (66.9%) diabetes cases identified in Saskatchewan, and LDL-C results were performed in 12,031 of 24,207 (49.7%) cases identified within the province's two largest health regions. The target A1C of (Source: BioMed C...
Blood Pressure-Lowering Diet May Reduce CHD Risk
In individuals with prehypertension or stage-1 hypertension, a diet high in fruits, vegetables, and
low-fat dairy, and low in fats and cholesterol appears to reduce the long-term risk of coronary heart disease,
according to a study published online Aug. 31 in Circulation: Cardiovascular Quality and Outcomes. (Source: Modern Medicine)
[Reflection and Reaction] Angiotensin-receptor blockade, cancer, and concerns
Ilke Sipahi and colleagues reported an increased risk of cancer, particularly lung cancer, in patients treated with angiotensin-receptor blockers (ARBs) in a recent issue of The Lancet Oncology. This meta-analysis has undoubtedly received a lot of attention and prompted us to consider the class effect of drugs that block the renin-angiotensin system. The ONTARGET trial showed similar and non-significant effects of telmisartan (an ARB) and ramipril?an angiotensin-converting enzyme (ACE) inhibitor?on the incidence of cancer. A significant effect (risk ratio 1·13, 95% CI 1·03?1·24; p=0·011) was recorded when telmisartan was assessed in those receiving ramipril, but the reverse analysis of the effect of ramipril on cancer incidence in those on the ARB has not been done. Of crucial im...
Researchers Tie Cholesterol Levels in Women to Menstrual Cycle Phase
Physicians testing a woman's cholesterol levels may need to take into account the phase of her menstrual cycle, according to a study published in the Journal of Clinical Endocrinology and Metabolism. In a study of more than 250 women ages 18-44 years, researchers from the Eunice Kennedy Shriver National Institute of Child Health and Human Development found that levels of HDL rose in concert with estrogen levels, peaking at the time of ovulation. (Source: AAFP Clinical Care and Research)
C-reactive Protein, Body Mass Index, and Diabetic Retinopathy [Clinical and Epidemiologic Research]
Conclusions.
Persons with diabetes who had higher levels of CRP and BMI were less likely to have DR. Further research is needed to understand the interrelationship role of inflammation, body weight, and microvascular complications. (Source: Investigative Ophthalmology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Impact of Common Medications on Serum Total Prostate-Specific Antigen Levels: Analysis of the National Health and Nutrition Examination Survey [Urologic Oncology]
Conclusion
We found that men using NSAIDs, statins, and thiazide diuretics have reduced PSA levels by clinically relevant amounts. The impact of regularly consuming these common medications on prostate cancer screening is unknown. (Source: Journal of Clinical Oncology)
Heart patients' lives at risk in switch to cheaper drugs
The Government's drive to switch patients to cheaper statins could put lives
at risk, new research has shown. (Source: Telegraph Health)
CTT meta-analysis: No cancer risk with statins, low LDL-cholesterol levels
Investigators report that statin therapy had no adverse effect on any cancer type, irrespective of how long patients took the cholesterol-lowering medications or their baseline LDL-cholesterol levels.
For complete story visit theheart.org. (Source: theHeart.org)
Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study
Conclusion: The results of this study suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate NP formation in combination with the effects of APOE 4. (Source: Neurology)
Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Physical Chemistry B)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: The Journal of Physical Chemistry B)
Low-Dose Omega-3 Fatty Acids Don't Protect Heart Patients
Title: Low-Dose Omega-3 Fatty Acids Don't Protect Heart PatientsCategory: Health NewsCreated: 8/29/2010 10:10:00 AMLast Editorial Review: 8/30/2010 (Source: MedicineNet Cholesterol General)
The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects.
Conclusions:
There is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms. (Source: Lipids in Health and Disease)
Metabolic syndrome predicts vascular changes in whole body magnetic resonance imaging in patients with long standing diabetes mellitus
Conclusion:
In this high-risk diabetic population, WB-MRA revealed large heterogeneity in the degree of systemic atherosclerosis. Presence and number of traits of the MetS are associated with the extent of atherosclerotic burden. These results support the perspective that diabetic patients are a heterogeneous population with increased but varying prevalence of atherosclerosis and risk. (Source: Cardiovascular Diabetology)
Cytotoxic effects of statins and thiazolidinediones on meningioma cells
Abstract Statins are inhibitors of the cholesterol synthesis pathway with pleiotropic effects, while thiazolidinediones (TDZ) are peroxisomal
proliferator activator receptor ? (PPAR-?) agonists with potent proapoptotic activity. For both groups of substances a cytotoxic
effect against several human tumors is presumed. Direct comparison of several statins and TDZ has not been performed on meningioma
cells until now. We compared the antiproliferative/cytotoxic effect of five statins, two TDZ, and their combinations on various
human meningioma cell lines and nontumorous cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT)
assay, cell cycle analysis, and caspase-3 assay. Simvastatin (SMV) and its combination with the TDZ pioglitazone (PGZ) turned
o...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort
Conclusions/interpretation In relatively healthy, middle-aged adults with type 1 diabetes who had been followed for an average of 18.5 years, long-term
metabolic control and microvascular factors are independently associated with a decline in cognitive function specifically
affecting measures of psychomotor efficiency.
Trial registration ClinicalTrials.gov NCT00360893
Funding This study is supported by NIH grant number 5RO1 DK062218-02. The DCCT/EDIC project is supported by contracts with the Division
of Diabetes, Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases,
the National Eye Institute, the National Institute of Neurological Disorders and Stroke, the General Clinical Re...
Physical functional health predicts the incidence of coronary heart disease in the European Prospective Investigation into Cancer-Norfolk prospective population-based study
Conclusions Physical functional health predicts subsequent CHD risk independently of known risk factors in a general population. People with poor physical functional health may benefit from targeted preventive interventions. (Source: International Journal of Epidemiology)
Snack Selection Influences Nutrient Intake, Triglycerides, and Bowel Habits of Adult Women: A Pilot Study
Abstract: Because appropriate snacking can promote a healthy body weight and serve as an important contributor to a healthy diet for women, identification of suitable foods for incorporation between meals is essential. We investigated the influence of short-term (2 weeks) incorporation of 100-kcal servings of snacks of dried plums vs low-fat cookies twice daily on total energy and nutrient intake, biochemical parameters, and bowel habits in a randomized crossover design of two 2-week trials separated by a 2-week wash-out period in 26 women aged 25 to 54 years with a body mass index between 24 and 35. Incorporation of dried plums or low-fat cookies into the diet did not alter energy intake or weight; however, compared to cookies, dried plums promoted greater (P?0.05) intake of fiber, pota...
Dietary Folic Acid Activates AMPK and Improves Insulin Resistance and Hepatic Inflammation in Dietary Rodent Models of the Metabolic Syndrome
Horm Metab ResDOI: 10.1055/s-0030-1263122AbstractThe AMP activated kinase plays an important role in metabolic control, and pharmacologic enhancement of AMPK activity is used to improve insulin resistance. We hypothesized that high dose of folic acid supplementation might improve insulin sensitivity and hepatic inflammation and examined this by a dietary intervention in (a) the high fat fed rat model of the metabolic syndrome, which shows sole hepatic steatosis as well as (b) in rats fed with a high cholesterol, high cholate diet inducing nonalcoholic steatohepatitis (NASH). Male Wistar rats were fed with folic acid supplemented (40 mg/kg) high fat diet [based on lard, fat content 25% (wt/wt)] or NASH inducing diet (containing 15% fat, 1.25% cholesterol, 0.5% sodium cholate). Metabol...
Reimbursement of pharmaceuticals: reference pricing versus health technology assessment
This study focussed on decisions about the initial price and reimbursement status of innovative drugs and
discussed the consequences for market access and cost. Four countries were studied: Germany, The Netherlands, Sweden and the
United Kingdom. These countries have operated one, or both, of the two policies at certain points in time, sometimes in parallel.
Drugs in four groups were considered: cholesterol-lowering agents, insulin analogues, biologic drugs for rheumatoid arthritis
and ?atypical? drugs for schizophrenia. Compared with HTA, reference pricing is a relatively blunt instrument for obtaining
value for money from pharmaceuticals. Thus, its role in making reimbursement decisions should be limited to drugs which are
therapeutically equivalent. HTA is a superior strategy ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Cholesterol rose after taking glucosamine and chondroitin
I took glucosamine and chondroitin for about seven months. I had gotten little relief for my back pain, but I was willing to continue it to see if eventually it would help. Around that time, I had blood work done and found that my cholesterol had jumped from under 200 to 239. I had made no changes in lifestyle or diet other than these supplements. I haven't taken any since. (Source: L.A. Times - Health)
Effects of cholesterol on CCK-1 receptors and caveolin-3 proteins recycling in human gallbladder muscle
The contraction of gallbladders (GBs) with cholesterol stones is impaired due to high cholesterol concentrations in caveolae compared with GBs with pigment stones. The reduced contraction is caused by a lower cholecystokinin (CCK)-8 binding to CCK-1 receptors (CCK-1R) due to caveolar sequestration of receptors. We aimed to examine the mechanism of cholesterol-induced sequestration of receptors. Muscle cells from human and guinea pig GBs were studied. Antibodies were used to examine CCK-1R, antigens of early and recycling endosomes, and total (CAV-3) and phosphorylated caveolar-3 protein (pCAV-3) by Western blots. Contraction was measured in muscle cells transfected with CAV3 mRNA or clathrin heavy-chain small-interfering RNA (siRNA). CCK-1R returned back to the bulk plasma membrane (PM) 30...
ESC: Switching Statins Often Leads to Wrong Doses (CME/CE)
STOCKHOLM (MedPage Today) -- A third of patients on lipid-lowering therapy received inadequate doses of generic simvastatin after being switched from atorvastatin (Lipitor), an analysis of a large pharmacy database showed. (Source: MedPage Today Cardiovascular)
Thyroid Hormone Receptor {beta} (TR{beta}) and Liver X Receptor (LXR) Regulate Carbohydrate-response Element-binding Protein (ChREBP) Expression in a Tissue-selective Manner [Metabolism]
Thyroid hormone (TR) and liver X (LXR) receptors are transcription factors involved in lipogenesis. Both receptors recognize the same consensus DNA-response element in vitro. It was previously shown that their signaling pathways interact in the control of cholesterol elimination in the liver. In the present study, carbohydrate-response element-binding protein (ChREBP), a major transcription factor controlling the activation of glucose-induced lipogenesis in liver, is characterized as a direct target of thyroid hormones (TH) in liver and white adipose tissue (WAT), the two main lipogenic tissues in mice. Using genetic and molecular approaches, ChREBP is shown to be specifically regulated by TRβ but not by TR in vivo, even in WAT where both TR isoforms are expressed. However, this isoty...
Identification of a Novel Distal Control Region Upstream of the Human Steroidogenic Acute Regulatory Protein (StAR) Gene That Participates in SF-1-dependent Chromatin Architecture [Gene Regulation]
StAR (steroidogenic acute regulatory protein) mediates the transport of cholesterol from the outer to the inner mitochondrial membrane, the process of which is the rate-limiting step for steroidogenesis. Transcriptional regulation of the proximal promoter of the human StAR gene has been well characterized, whereas analysis of its distal control region has not. Recently, we found that SF-1 (steroidogenic factor 1) induced the differentiation of mesenchymal stem cells (MSCs) into steroidogenic cells with the concomitant strong induction of StAR expression. Here, we show, using differentiated MSCs, that StAR expression is regulated by a novel distal control region. Using electrophoretic mobility shift (EMSA) and chromatin immunoprecipitation (ChIP) assays, we identified novel SF-1 binding sit...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
TR{beta} and LXR Regulate ChREBP in a Tissue-selective Manner [Metabolism]
Thyroid hormone (TR) and liver X (LXR) receptors are transcription factors involved in lipogenesis. Both receptors recognize the same consensus DNA-response element in vitro. It was previously shown that their signaling pathways interact in the control of cholesterol elimination in the liver. In the present study, carbohydrate-response element-binding protein (ChREBP), a major transcription factor controlling the activation of glucose-induced lipogenesis in liver, is characterized as a direct target of thyroid hormones (TH) in liver and white adipose tissue (WAT), the two main lipogenic tissues in mice. Using genetic and molecular approaches, ChREBP is shown to be specifically regulated by TRβ but not by TR in vivo, even in WAT where both TR isoforms are expressed. However, this isoty...
Identification of a Novel Distal Control Region in Human StAR [Gene Regulation]
StAR (steroidogenic acute regulatory protein) mediates the transport of cholesterol from the outer to the inner mitochondrial membrane, the process of which is the rate-limiting step for steroidogenesis. Transcriptional regulation of the proximal promoter of the human StAR gene has been well characterized, whereas analysis of its distal control region has not. Recently, we found that SF-1 (steroidogenic factor 1) induced the differentiation of mesenchymal stem cells (MSCs) into steroidogenic cells with the concomitant strong induction of StAR expression. Here, we show, using differentiated MSCs, that StAR expression is regulated by a novel distal control region. Using electrophoretic mobility shift (EMSA) and chromatin immunoprecipitation (ChIP) assays, we identified novel SF-1 binding sit...
Do Caveolae Have a Role in the Fidelity and Dynamics of Receptor Activation of G-protein-gated Inwardly Rectifying Potassium Channels? [Membrane Biology]
In atrial and nodal cardiac myocytes, M2 muscarinic receptors activate inhibitory G-proteins (Gi/o), which in turn stimulate G-protein-gated inwardly rectifying K+ channels through direct binding of the Gβ subunit. Despite also releasing Gβ, Gs-coupled receptors such as the β-adrenergic receptor are not able to prominently activate this current. An appealing hypothesis would be if components were sequestered in membrane domains such as caveolae/rafts. Using biochemical fractionation followed by Western blotting and/or radioligand binding experiments, we examined the distribution of the components in stable HEK293 and HL-1 cells, which natively express the transduction cascade. The channel, M2 muscarinic, and A1 adenosine receptors were located in noncaveolar/nonraft fraction...
Purinergic Receptor-mediated Rapid Depletion of Nuclear Phosphorylated Akt Depends on Pleckstrin Homology Domain Leucine-rich Repeat Phosphatase, Calcineurin, Protein Phosphatase 2A, and PTEN Phosphatases [Cell Biology]
Akt is an important oncoprotein, and data suggest a critical role for nuclear Akt in cancer development. We have previously described a rapid (3–5 min) and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream targets, and here we studied mechanisms behind the pAkt depletion. We show that cholesterol-lowering drugs, statins, or extracellular ATP, induced a complex and coordinated response in insulin-stimulated A549 cells leading to depletion of nuclear pAkt. It involved protein/lipid phosphatases PTEN, pleckstrin homology domain leucine-rich repeat phosphatase (PHLPP1 and -2), protein phosphatase 2A (PP2A), and calcineurin. We employed immunocytology, immunoprecipitation, and proximity ligation assay techniques and show that PHLPP and calcineurin tra...
Caveolae and GIRK Channels [Membrane Biology]
In atrial and nodal cardiac myocytes, M2 muscarinic receptors activate inhibitory G-proteins (Gi/o), which in turn stimulate G-protein-gated inwardly rectifying K+ channels through direct binding of the Gβ subunit. Despite also releasing Gβ, Gs-coupled receptors such as the β-adrenergic receptor are not able to prominently activate this current. An appealing hypothesis would be if components were sequestered in membrane domains such as caveolae/rafts. Using biochemical fractionation followed by Western blotting and/or radioligand binding experiments, we examined the distribution of the components in stable HEK293 and HL-1 cells, which natively express the transduction cascade. The channel, M2 muscarinic, and A1 adenosine receptors were located in noncaveolar/nonraft fraction...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
pAkt Depletion by Protein and Lipid Phosphatases [Cell Biology]
Akt is an important oncoprotein, and data suggest a critical role for nuclear Akt in cancer development. We have previously described a rapid (3–5 min) and P2X7-dependent depletion of nuclear phosphorylated Akt (pAkt) and effects on downstream targets, and here we studied mechanisms behind the pAkt depletion. We show that cholesterol-lowering drugs, statins, or extracellular ATP, induced a complex and coordinated response in insulin-stimulated A549 cells leading to depletion of nuclear pAkt. It involved protein/lipid phosphatases PTEN, pleckstrin homology domain leucine-rich repeat phosphatase (PHLPP1 and -2), protein phosphatase 2A (PP2A), and calcineurin. We employed immunocytology, immunoprecipitation, and proximity ligation assay techniques and show that PHLPP and calcineurin tra...
Synthesis of 7-Hydroperoxycholesterol and Its Separation, Identification, and Quantification in Cholesterol Heated Model Systems
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Stem cells converted to liver cells
Conclusion
This laboratory study has developed a method to produce liver cells from skin cells by producing inducible stem cells. The study showed the potential of this technique to produce cell culture models of inherited liver diseases. As the researchers point out, this is likely to be a useful tool to learn more about these diseases and screen for useful drugs.
However, this research was not done with the intention of growing transplantable livers, as suggested by the Daily Mail. A liver is comprised of a complex tissue of different types of cell and it has not been investigated whether the cells developed here could have the potential to be transplanted.
This is promising preliminary research which may lead to advances in the understanding of inherited liver diseases and in treatments...
Use of Evidence-Based Therapy for the Prevention of Cardiovascular Events Among Older people
Evidence-based therapies (EBTs) for the prevention of cardiovascular disease (CVD) are reportedly underutilized in older people. The primary purpose of this study was to evaluate the use of EBTs for the prevention of CVD events in older people and secondarily whether a Home Medicines Review (HMR) service by pharmacists’ predicts the use of these medicines. A retrospective cross-sectional audit of HMR reports pertaining to 608 community-dwelling older people (≥65 years) was conducted. EBTs considered for this audit included four guideline-recommended therapies for CVD: antithrombotic therapy (warfarin ± antiplatelet therapy), β-blockers, statins, and angiotensin agents (angiotensin-converting enzyme inhibitors [ACEI] ± angiotensin II receptor blockers [ARBs]). Th...
Switching to less potent statin after ACS linked to adverse outcomes
Patients with acute coronary syndromes who switch from intensive to moderate statin therapy are at increased risk for mortality, repeat myocardial infarction, and stroke, a study suggests. (Source: MedWire News - Lipidology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Lack of association between cerebral microbleeds and low serum cholesterol in patients with acute intracerebral hemorrhage
Conclusion: In this study, 61% of Turkish ICH patients had CMBs, which was not associated with lipid profiles. Leukoaraiosis was independently associated with CMBs. (Source: Clinical Neurology and Neurosurgery)
Obstetrician-gynecologists' approach to well-woman care.
CONCLUSION:: The majority of obstetrician-gynecologists define well-woman care as overall health and primary care, and their opinions and practices reflect this. LEVEL OF EVIDENCE:: III.
PMID: 20733457 [PubMed - in process] (Source: Obstetrics and Gynecology)
Association of polymorphisms within the transforming growth factor??1 gene with diabetic nephropathy and serum cholesterol and triglyceride concentrations
ABSTRACT (Source: Nephrology)
Statin use and decreased risk of benign prostatic enlargement and lower urinary tract symptoms
(Source: BJU International)
Abstracts of Current Literature
CONCLUSION: In this multi-ethnic cohort, addition of CACS to a prediction model based on traditional risk factors significantly improved the classification of risk and placed more individuals in the most extreme risk categories. (Source: Journal of Vascular and Interventional Radiology : JVIR)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Black Rice Is Cheap Way to Get Antioxidants
Title: Black Rice Is Cheap Way to Get AntioxidantsCategory: Health NewsCreated: 8/27/2010 10:06:00 AMLast Editorial Review: 8/27/2010 10:06:13 AM (Source: MedicineNet Cholesterol General)
Office Management of Peripheral Arterial Disease
Abstract: Patients with peripheral arterial disease are at increased risk for all-cause mortality, cardiovascular mortality, and mortality from coronary artery disease. Smoking should be stopped, and hypertension, diabetes mellitus, and dyslipidemia should be treated. Statins reduce the incidence of intermittent claudication and increase exercise duration until the onset of intermittent claudication in patients with peripheral arterial disease and hypercholesterolemia. Antiplatelet drugs, such as aspirin or clopidogrel, angiotensin-converting enzyme inhibitors, and statins, should be given to all patients with peripheral arterial disease. Beta-blockers should be given if coronary artery disease is present. Exercise rehabilitation programs and cilostazol improve exercise time until the onse...
The Most Important Neurologic Reflex!
A 56-year-old woman was admitted for back surgery. She had a long history of low back pain with an unchanging radiation of pain down the lateral aspect of her right leg to the foot. Two weeks before admission, she developed a sudden weakness of her right foot and foreleg. Notably, the pain was not worse with coughing or sneezing. Her medical history was unremarkable except for hypertension and some elevated lipids found on a screening test 2 years before admission; she was receiving a diuretic and a statin for these conditions. (Source: The American Journal of Medicine)
Correction
Bailey D, Jahagirdar R, Gordon A, et al. RVX-208: A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo. J Am Coll Cardiol 2010;55:2580?9. (Source: Journal of the American College of Cardiology)
[Role of rosuvastatin in lipid-lowering therapy today.]
Authors: Abel T, Fehér J
Statins are the most widely used lipid-lowering therapy. Among them, the rosuvastatin can be well tolerated and effectively helps to reach LDL-cholesterol goals in primary and secondary cardiovascular prevention. In addition, rosuvastatin reduces triglyceride and high-sensitivity C-reactive protein level and increases high-density lipoprotein (HDL) cholesterol, too. Imaging studies demonstrated that rosuvastatin therapy can not only reduce atherosclerosis progression but might induce its regression too.
PMID: 20719717 [PubMed - in process] (Source: Orvosi Hetilap)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Meta-analysis: High-density lipoprotein cholesterol increase and non-cardiovascular mortality
Source: Heart
Area: News
The results of this meta-analysis suggest that increases in high-density lipoprotein (HDL) cholesterol of up to 40% are not associated with higher non-cardiovascular death. The authors note that various observational prospective studies have confirmed the inverse relationship between HDL cholesterol and coronary heart disease. Therefore clinical guidelines for the prevention and treatment of cardiovascular disease acknowledge HDL cholesterol as an independent risk factor. However, trials aiming to demonstrate the potential benefit of improving cardiovascular prognosis by increasing HDL concentration have been mostly unsuccessful. Furthermore, some research has reported an increase in total non-cardiovascular mortality.
The reviewers therefore tried to ...
Anti-hyperlipidemic and insulin sensitizing activities of fenofibrate reduces aortic lipid deposition in hyperlipidemic Golden Syrian hamster.
In this study, we aimed to: a) evaluate hamster as a model for insulin resistance, hyperlipidemia and atherosclerosis; and b) investigate the effect of a PPAR-alpha activator, fenofibrate, in this model. A high fat high cholesterol (HFHC) diet increased serum cholesterol and triglycerides, but inclusion of fenofibrate in the diet decreased cholesterol and proatherogenic lipoproteins, VLDL and LDL, in a time-dependent manner. Concomitantly, serum levels of triglycerides also decreased. These reductions were attributed, in part, to the down-regulation of lipogenic genes and upregulation of lipoprotein lipase. The HFHC diet caused body weight gain and mild insulin resistance, both of which were prevented following the treatments with fenofibrate. Insulin resistance was further investigated in...
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease
Background:
The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up. We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steady-state children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, anti-aggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis.
Methods:
We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counte...
Dietary Folic Acid Activates AMPK and Improves Insulin Resistance and Hepatic Inflammation in Dietary Rodent Models of the Metabolic Syndrome
Horm Metab ResDOI: 10.1055/s-0030-1263122AbstractThe AMP activated kinase plays an important role in metabolic control, and pharmacologic enhancement of AMPK activity is used to improve insulin resistance. We hypothesized that high dose of folic acid supplementation might improve insulin sensitivity and hepatic inflammation and examined this by a dietary intervention in (a) the high fat fed rat model of the metabolic syndrome, which shows sole hepatic steatosis as well as (b) in rats fed with a high cholesterol, high cholate diet inducing nonalcoholic steatohepatitis (NASH). Male Wistar rats were fed with folic acid supplemented (40 mg/kg) high fat diet [based on lard, fat content 25% (wt/wt)] or NASH inducing diet (containing 15% fat, 1.25% cholesterol, 0.5% sodium cholate). Metabol...
Cytomegalovirus Infection Leads to Microvascular Dysfunction and Exacerbates Hypercholesterolemia-Induced Responses.
This study determined whether CMV also impairs microvascular homeostasis and synergizes with hypercholesterolemia to exaggerate these responses. Intravital microscopy was used to assess endothelium-dependent and -independent arteriolar vasodilation and venular leukocyte and platelet adhesion in mice after injection with either mock inoculum or murine CMV (mCMV). Mice were fed a normal (ND) or high-cholesterol (HC) diet beginning at 5 weeks postinfection (p.i.), or a HC diet for the final 4 weeks of infection. mCMV-ND mice exhibited impaired endothelium-dependent vasodilation versus mock-ND at 9 and 12 weeks and endothelium-independent arteriolar dysfunction by 24 weeks. Transient mild leukocyte adhesion occurred in mCMV-ND venules at 7 and 21 weeks p.i. HC alone caused temporary arteriolar...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Researchers Recommend Statins with Your Fries
Restaurant patron: “Gimme the chocolate milk shake and the cheeseburger deluxe.” Waitress: “That’s the cheeseburger with lettuce, tomato, onion, fries and statin pill, coming right up.” [More] (Source: Scientific American - Official RSS Feed)
PSA levels could drop with commonly prescribed drugs
The lowest readings were associated with a combination of statins and thiazide diuretics, a study says. (Source: American Medical News - PROFESSION)
Cognitive decline precedes late-life longitudinal changes in vascular risk factors
Discussion
In old age, cognitive decline precedes declines in total cholesterol levels, HDL cholesterol levels and blood pressure, and not vice versa. Possibly, brain lesions in metabolic and blood pressure regulation centres cause dysregulation of lipid metabolism and blood pressure. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the USA (NHANES)
Conclusions
These results are consistent with the context-specific nature of educational differences in risk factors for CVD and with a non-uniform nature of association of CVD risk factors with education within countries. Our results also demonstrate that social equity in mortality is achieved without uniform equity in all risk factors. (Source: Journal of Epidemiology and Community Health)
BAS/BSCR27 Diesel exhaust particles promote atherosclerosis in apolipoprotein E-deficient mice
Air pollution has been linked to the development of atherosclerosis and cardiovascular disease. Diesel exhaust particulate (DEP) accounts for a substantial proportion of urban air pollution but its effects on atherogenesis are unknown. We hypothesised that DEP will exacerbate plaque formation in a murine model of atherosclerosis.
Apolipoprotein E knockout (ApoE) mice (10–12 weeks; n=16) were fed a ‘Western diet’ (21% cholesterol) for 8 weeks to induce the development of ‘complex’ atherosclerotic plaques. During the last 4 weeks of feeding, mice underwent twice-weekly intratracheal instillation of 35 µl DEP (1 mg/ml; National Institute of Standards and Technology) or vehicle (saline).
Histological sections of the brachiocephalic a...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
BAS/BSCR54 The hypolipidaemic activity of novel indole-2-carboxamides in Triton WR-1339-induced hyperlipidaemic rats: a comparison with bezafibrate
Using Triton WR-1339-induced hyperlipidaemic rats as an experimental model, we investigated whether compound 1 (N-(3-benzoylphenyl)-1H-indole-2-carboxamide) and 2 (N-(4-benzoylphenyl)-1H-indole-2-carboxamide) novel anti-hyperlipidaemic agents have any effect on plasma triglyceride, total cholesterol (TC) and high-density lipoprotein cholesterol levels (HDL-C) levels. Hyperlipidaemia was developed by intraperitoneal injection of Triton WR-1339 (200 mg/kg body weight). At a dose of 15 mg/kg body weight, compounds 1, 2 and bezafibrate (BF) significantly reduced the elevated plasma triglyceride levels after 7 and 24 h. Furthermore, HDL-C levels were remarkably increased in all treated groups after 7 and 24 h compared with the hyperlipidaemic control group. However, only compounds 1 and 2-treat...
YIA2 11{beta}-HSD1 deficiency attenuates atherosclerosis in ApoE-/- mice: role of both glucocorticoid and non-glucocorticoid (oxysterol) factors
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoids, amplifying intracellular actions.1 11β-HSD1 deficiency or inhibition improves metabolic syndrome and attenuates atherosclerosis in vulnerable rodent strains and is a target for drug development.2–4 However, 11β-HSD1 also catalyses conversion of 7-ketocholesterol,5 which accumulates in fatty tissues,6 to potentially more atherogenic 7β-hydroxycholesterol. Whether atheroprotection with 11β-HSD1 deficiency is dependent on glucocorticoid or oxysterol effects is unknown. Male atherosclerosis-prone ApoE–/– and ApoE–/–.11β-HSD1–/– double knockout (DKO) mice underwent adrenalectomy or sham surgery (n=8/group), then received a high (0.2%...
FC2 Activating transcription factor 1 co-regulates iron, lipid and anti-inflammatory target genes to direct a novel atheroprotective human plaque macrophage subset
Conclusions
Our data define the molecular basis of the differentiation of M-haem, a novel atheroprotective macrophage subset. Our data indicate that redirection of macrophage phenotype in atherosclerosis progression is a modality appropriate for therapeutic development. (Source: Heart)
FC4 The alternative pathway is critical for pathogenic complement activation in diet -induced and endotoxin-induced atherosclerosis in low-density lipoprotein receptor-deficient mice
Our previous studies have shown that the early components of the classical complement pathway protect low-density lipoprotein receptor deficient mice (Ldlr–/–) from atherogenesis when fed a low-fat diet. However, the role of the alternative pathway remains unknown. To investigate this, we crossed mice lacking the alternative pathway activator Factor B (Bf–/–) with Ldlr–/– mice. Lipid profiles after 12 weeks on a high-fat diet showed significantly reduced levels of total cholesterol (25.2%±0.9 mmol/l, n=14, vs 40.5%±1.8 mmol/l, n=17, p<0.0001) and lipoproteins (~1.5-fold lower VLDL and LDL) in the Bf–/–.Ldlr–/– mice compared with the Ldlr–/– animals. Consistent with this, high-fat fed Bf&...
BAS/BSCR9 Proteomic characterisation of extracellular space components in the human aorta
Conclusions
We expect this new proteomic method to shed light on the composition and breakdown of extracellular matrix within cardiovascular tissues and provide insights into important pathological processes, such as plaque rupture, aneurysm formation and restenosis. (Source: Heart)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
High-density lipoprotein cholesterol increase and non-cardiovascular mortality: a meta-analysis
Conclusions
Meta-regression analysis results suggest that increases in HDL cholesterol up to 40% are not associated with higher non-cardiovascular death. The increase in adverse events observed in some trials where HDL cholesterol was raised in large amounts could be related with the drug mechanisms more than the HDL cholesterol increase itself. (Source: Heart)
'Grapefruit diabetes cure' unproven
Conclusion
This complex laboratory research suggests that naringenin can affect proteins and genes involved in fat metabolism in liver cells. Although the effect that it has on the cells is similar to the effects of drugs such as the fibrates and glitazones, this does not necessarily mean that naringenin could be used to treat the same conditions as the fibrates and glitazones. In the body different drugs interact with different subsets of the numerous proteins and molecules in the body in different ways. It is these complex interactions which will determine their overall effects. This study has only assessed interactions of naringenin with a small number of proteins in cells in the laboratory, and cannot tell us what the overall balance of positive and negative effects will be on the whol...
Prostate Cancer Treatment Expert Dr. David Samadi, MD Discusses Preventive Medicine Versus Treatment Or Outcome-Based Medicine
Starting in September, President Obama's Affordable Care Act will go into effect. The act mandates free preventative services such as cholesterol or breast cancer screenings and tetanus shots. But the question is, will doctors and patients take advantage of these new preventative services? "Unfortunately, thanks to our American healthcare system, we have been programmed to focus on treatment and not prevention," said Dr... (Source: Health News from Medical News Today)
Expanded Lipoprotein Testing, VAP® Cholesterol Test Discussed At National Lipid Association Summer Clinical Lipid Update
Atherotech Diagnostics Lab will exhibit its VAP® Cholesterol Test in booth 105 at the National Lipid Association (NLA) Summer 2010 Clinical Lipid Update. The meeting takes place August 27-29 at the Mayflower Hotel in Washington, D.C. Expert faculty and thought leaders will share their insights and expand attendees' knowledge of comprehensive lipid testing and emerging therapies for dyslipidemia and related cardiometabolic conditions. Members of Atherotech's Medical Advisory Board, Michael H. Davidson, M.D., and Peter P. Toth, M.D., Ph.D... (Source: Health News from Medical News Today)
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
Human induced pluripotent stem (iPS) cells hold great promise for advancements in developmental biology, cell-based therapy, and modeling of human disease. Here, we examined the use of human iPS cells for modeling inherited metabolic disorders of the liver. Dermal fibroblasts from patients with various inherited metabolic diseases of the liver were used to generate a library of patient-specific human iPS cell lines. Each line was differentiated into hepatocytes using what we believe to be a novel 3-step differentiation protocol in chemically defined conditions. The resulting cells exhibited properties of mature hepatocytes, such as albumin secretion and cytochrome P450 metabolism. Moreover, cells generated from patients with 3 of the inherited metabolic conditions studied in further detail...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Reply to: de Souza JC, de Oliveira CAM, Carneiro EM et al. [letter]
Content Type Journal ArticleDOI 10.1007/s00125-010-1877-7Authors
J. K. Kruit, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Ave, Vancouver, BC Canada V5Z 4H4L. R. Brunham, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Ave, Vancouver, BC Canada V5Z 4H4C. B. Verchere, Child and Family Research Institute, Department of Surgery, University of British Columbia, Vancouver, BC CanadaM. R. Hayden, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Ave, V...
Pharmacomodulation of High-Density Lipoprotein Metabolism as a Therapeutic Intervention for Atherosclerotic Disease
Abstract The high-density lipoproteins (HDLs) are produced by the liver and small intestine as well as on the surface of lipid-enriched
macrophages in the subendothelial space of arterial walls. Unlike the apo B100-containing lipoproteins, the HDLs are uniquely
antiatherogenic. Based on prospective observational studies performed throughout the world, there is a consistent inverse
relationship between serum levels of HDLs and risk for cardiovascular events: low levels of high-density lipoprotein-cholesterol
(HDL-C) are associated with increased risk, whereas high levels are usually associated with reduced risk for myocardial infarction,
ischemic stroke, and cardiovascular mortality. Post hoc analyses of a number of studies using statins and fibrates have shown
that raising...
People At "Intermediate Risk" Of Heart Disease With Elevated HsCRP Benefit From Statin Therapy Even If Cholesterol Levels Are Normal
Women and men with a 10-year cardiovascular disease risk of 5 percent or more and normal cholesterol levels but high levels of hsCRP, a protein associated with inflammation, could reduce their risk substantially with statin therapy, according to new research. The study, published in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, is a new analysis of data from the randomized, placebo-controlled, double blind Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)... (Source: Health News from Medical News Today)
Study Suggests Statins Could Help Some With Normal Cholesterol
Title: Study Suggests Statins Could Help Some With Normal CholesterolCategory: Health NewsCreated: 8/25/2010 12:10:00 PMLast Editorial Review: 8/26/2010 (Source: MedicineNet Cholesterol General)
Study Suggests Statins Could Help Some With Normal Cholesterol
Title: Study Suggests Statins Could Help Some With Normal CholesterolCategory: Health NewsCreated: 8/25/2010 12:10:00 PMLast Editorial Review: 8/26/2010 (Source: MedicineNet Heart General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Study Suggests Statins Could Help Some With Normal Cholesterol
Title: Study Suggests Statins Could Help Some With Normal CholesterolCategory: Health NewsCreated: 8/25/2010 12:10:00 PMLast Editorial Review: 8/26/2010 (Source: MedicineNet Senior Health General)
Lipoprotein levels and cardiovascular risk in HIV infected and uninfected Rwandan women
Background:
Lipoprotein profiles in HIV-infected African women have not been well described. We assessed associations of lipoprotein levels and cardiovascular risk with HIV-infection and CD4 count in Rwandan women.
Methods:
Cross-sectional study of 824 (218 HIV-negative, 606 HIV+) Rwandan women. Body composition by body impedance analysis, CD4 count, and fasting serum total cholesterol (total-C), triglycerides (TG) and high-density lipoprotein (HDL) levels were measured. Low-density lipoprotein (LDL) was calculated from Friedewald equation if TG (Source: AIDS Research and Therapy)
Triglyceride Level Affecting Shared Susceptibility Genes in Metabolic Syndrome and Coronary Artery Disease.
Authors: Kisfali P, Polgár N, Sáfrány E, Sümegi K, Melegh BI, Bene J, Wéber A, Hetyésy K, Melegh B
Metabolic syndrome is characterized primarily by abdominal obesity, high triglyceride- and low HDL cholesterol levels, elevated blood pressure, and increased fasting glucose levels, which are often associated with coronary heart diseases. Several factors, such as physical inactivity, age, and several endocrine and genetic factors can increase the risk of the development of the disease. Gathered evidence shows, that metabolic syndrome is not only a risk factor for cardiovascular disease, but often both of them have the same shared susceptibility genes, as several genetic variants have shown a predisposition to both diseases. Due to the spread of robust genome wide associa...
Lipoprotein levels and cardiovascular risk in HIV infected and uninfected Rwandan women.
CONCLUSIONS: In this cohort of non-obese African women HDL and TG, but not LDL, were adversely associated with HIV infection. As HDL is a strong predictor of cardiovascular (CV) events in women, this HIV-associated difference may confer increased risk for CV disease in HIV-infected women.
PMID: 20796311 [PubMed - as supplied by publisher] (Source: AIDS Research and Therapy)
Pioglitazone-Induced Reductions in Atherosclerosis Occur via Smooth Muscle Cell-Specific Interaction With PPAR{gamma}
Conclusions: Pio attenuates Ang II-induced atherosclerosis via the interaction with SMC-specific PPARgamma, but has no effect on the development of AAAs.
PMID: 20798360 [PubMed - as supplied by publisher] (Source: Circulation Research)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Statin use after stroke rising slowly
NEW YORK (Reuters Health) - Most stroke patients leave the hospital with cholesterol-lowering statin drugs, a nationwide US study shows, in keeping with medical guidelines. (Source: Reuters: Health)
Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization
In conclusion, our findings demonstrate the importance of membrane composition for GHSR activation and desensitization and indicate at least part of the mechanism through which OFAs and cholesterol could affect ghrelin's activity in vivo. (Source: AJP: Endocrinology and Metabolism)
Special Report: Your Lower Cholesterol Toolbox
(Source: WebMD Health)
Statin Use After Stroke Rising Slowly
Most stroke patients leave the hospital with cholesterol-lowering statin drugs, a nationwide US study shows, in keeping with medical guidelines.Source: Reuters Health
Related MedlinePlus Pages: Statins, Stroke (Source: MedlinePlus Health News)
Erratum: Acyl-Chain Mismatch Driven Superlattice Arrangements in DPPC/DLPC/Cholesterol Bilayers
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Physical Chemistry B)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Erratum: Acyl-Chain Mismatch Driven Superlattice Arrangements in DPPC/DLPC/Cholesterol Bilayers
The Journal of Physical Chemistry B, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: The Journal of Physical Chemistry B)
JUPITER: Statin Therapy Effective in Intermediate-Risk, High-CRP Patients
When stratified by the underlying level of absolute risk, JUPITER patients with elevated CRP levels and a 5% to 20% 10-year risk of cardiovascular disease benefited from statin therapy, report investigators. Heartwire (Source: Medscape Today Headlines)
Merck sues generic drugmaker over Vytorin patent infringement
Merck is suing Impax Laboratories to prevent the company from selling a copycat version of Vytorin, the controversial cholesterol-lowering medication.
For complete story visit theheart.org. (Source: theHeart.org)
Study Suggests Statins Could Help Some With Normal Cholesterol
These people have elevated levels of high sensitivity C-reactive protein, researchers say (Source: The Doctors Lounge - Cardiology)
ESC: Statins Cleared of Causing Cancer (CME/CE)
STOCKHOLM (MedPage Today) -- In what may be the final word on the issue, researchers said here that statins neither cause nor prevent cancer. (Source: MedPage Today Cardiovascular)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
People at 'Intermediate Risk' of Heart Disease With Elevated hsCRP Benefit From Statin Therapy Even if Cholesterol Levels are Normal
Study highlights:
-- People at intermediate risk of cardiovascular disease who
have high levels of high sensitivity C-reactive protein (hsCRP), a
blood marker for inflammation, could benefit from
cholesterol-lowering therapy even if their... (Source: Drugs.com - Clinical Trials)
Migraine with aura linked to heart risk
Conclusion
This is a large, cohort study with a lengthy follow-up. There are several limitations that should be taken into account when interpreting this research.
Only people who reported more than one headache a month were asked about their migraine features. Therefore, the people with migraines included in this study may only have been those experiencing high frequency migraine attacks.
The proportion of migraine sufferers who experienced aura is higher than reported in other population studies. The researchers say that this may be due to non-aura-specific visual symptoms such as vision blurring being classified as an aura. They also say that the combination of visual symptoms and headache can be symptoms of transient ischemic attack or mini stroke (a short lasting change in blood...
Migraine with aura and heart risk
Conclusion
This is a large, cohort study with a lengthy follow-up. There are several limitations that should be taken into account when interpreting this research.
Only people who reported more than one headache a month were asked about their migraine features. Therefore, the people with migraines included in this study may only have been those experiencing high frequency migraine attacks.
The proportion of migraine sufferers who experienced aura is higher than reported in other population studies. The researchers say that this may be due to non-aura-specific visual symptoms such as vision blurring being classified as an aura. They also say the combination of visual symptoms and headache can be symptoms of transient ischemic attack or mini stroke (a short lasting change in blood flow...
Circ: Statins acceptable therapy even for intermediate CV risk patients
For certain subsets of patients--those at an ?intermediate risk? for cardiovascular (CV) disease and who have low LDL cholesterol levels and elevated high-sensitivity C-reactive proteins (hsCRP)--the use of rosuvastatin (Crestor, AstraZeneca) significantly decreases CV risk, according to the results of a substudy of the JUPITER trial published in the September edition of Circulation: Cardiovascular Quality Outcomes. (Source: Cardiovascular Business News)
Circ: Statins acceptable even for intermediate CV risk patients
For certain subsets of patients--those at an ?intermediate risk? for cardiovascular (CV) disease and who have low LDL cholesterol levels and elevated high-sensitivity C-reactive proteins (hsCRP)--the use of rosuvastatin (Crestor, AstraZeneca) significantly decreases CV risk, according to the results of a substudy of the JUPITER trial published in the September edition of Circulation: Cardiovascular Quality Outcomes. (Source: Cardiovascular Business News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
People At 'Intermediate Risk' Of Heart Disease With Elevated HsCRP Benefit From Statin Therapy Even If Cholesterol Levels Are Normal
Women and men with a 10-year cardiovascular disease risk of 5 percent or more and normal cholesterol levels but high levels of hsCRP, a protein associated with inflammation, could reduce their risk substantially with statin therapy, according to new research. The study, published in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, is a new analysis of data from the randomized, placebo-controlled, double blind Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)... (Source: Health News from Medical News Today)
Young and healthy? Watch the cholesterol
Young adults out there, take note: The occasional Big Mac, slice of pizza or ice cream cookie binge may be fine — but you'd be wise not to make a habit out of it.
Consistently high levels of low-density lipoprotein (LDL or "bad") cholesterol... (Source: OrlandoSentinel: Medical Research)
GPs call for better checks on pharmacist supply of statins
GPs have called for an overhaul of guidelines for pharmacists supplying simvastatin over the counter, saying they should routinely conduct cholesterol and blood pressure checks. (Source: Pulse)
Migraines With Aura May Raise Stroke Risk
Title: Migraines With Aura May Raise Stroke RiskCategory: Health NewsCreated: 8/25/2010 11:04:00 AMLast Editorial Review: 8/25/2010 11:04:22 AM (Source: MedicineNet Cholesterol General)
Abnormal Heart Rhythms (Heart Rhythm Disorders)
Title: Abnormal Heart Rhythms (Heart Rhythm Disorders)Category: Diseases and ConditionsCreated: 10/15/2007Last Editorial Review: 8/25/2010 (Source: MedicineNet Cholesterol General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Pump Placed in Aorta Doesn't Improve Angioplasty Outcomes: Study
Title: Pump Placed in Aorta Doesn't Improve Angioplasty Outcomes: StudyCategory: Health NewsCreated: 8/24/2010 4:10:00 PMLast Editorial Review: 8/25/2010 (Source: MedicineNet Cholesterol General)
Heart Risks the Same With 2 Diabetes Drugs: Study
Title: Heart Risks the Same With 2 Diabetes Drugs: StudyCategory: Health NewsCreated: 8/24/2010 6:10:00 PMLast Editorial Review: 8/25/2010 (Source: MedicineNet Cholesterol General)
Hypovitaminosis D and cardiometabolic risk factors among non-obese youth
In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic
parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective
clinical intervention studies are needed to validate this hypothesis.
Content Type Journal ArticleDOI 10.2478/s11536-010-0045-2Authors
Nasser M. Al-Daghri, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451 Riyadh, Kingdom of Saudi ArabiaOmar S. Al-Attas, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451 Riyadh, Kingdom of Saudi ArabiaMajed S. Alokail, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451 Riyadh, Kingdom of Saudi ArabiaKhalid M Alkharfy, Clinical Pharmacy Depart...
People at ?intermediate risk? of heart disease with elevated hsCRP benefit from statin therapy even if cholesterol levels are normal
Individuals with a 10-year cardiovascular disease risk of 5 percent or more and normal cholesterol levels but high levels of hsCRP could reduce their risk with statin therapy. (Source: BWH for Journalists)
People at ?intermediate risk? of heart disease with elevated hsCRP benefit from statin therapy even if cholesterol levels are normal
Individuals with a 10-year cardiovascular disease risk of 5 percent or more and normal cholesterol levels but high levels of hsCRP could reduce their risk with statin therapy. (Source: BWH News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
People at "Intermediate Risk" of Heart Disease with Elevated hsCRP Benefit from Statin Therapy Even If Cholesterol Levels Are Normal
Source: American Heart Association
Related MedlinePlus Pages: Heart Diseases--Prevention, Statins (Source: MedlinePlus Health News)
Statin Benefits Those With High hsCRP, Intermediate CVD Risk
Rosuvastatin may reduce the risk of major adverse cardiovascular events in men and women with normal
cholesterol but elevated high-sensitivity C-reactive protein levels who are at intermediate risk for cardiovascular
disease, according to research published online Aug. 24 in Circulation: Cardiovascular Quality and
Outcomes. (Source: Modern Medicine)
Statin Benefits Those With High hsCRP, Intermediate CVD Risk
Rosuvastatin may reduce the risk of major adverse cardiovascular events in men and women with normal
cholesterol but elevated high-sensitivity C-reactive protein levels who are at intermediate risk for cardiovascular
disease, according to research published online Aug. 24 in Circulation: Cardiovascular Quality and
Outcomes. (Source: Modern Medicine)
Differential Response of Endothelial Cells to Simvastatin When Conditioned with Steady, Non-Reversing Pulsatile or Oscillating Shear Stress.
Authors: Rossi J, Jonak P, Rouleau L, Danielczak L, Tardif JC, Leask RL
Few studies have investigated whether fluid mechanics can impair or enhance endothelial cell response to pharmacological agents such as statin drugs. We evaluated and compared Kruppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS), and thrombomodulin (TM) expression in human abdominal aortic endothelial cells (HAAEC) treated with increasing simvastatin concentrations (0.1, 1 or 10 muM) under static culture and shear stress (steady, non-reversing pulsatile, and oscillating). Simvastatin, steady flow, and non-reversing pulsatile flow each separately upregulated KLF2, eNOS, and TM mRNA. At lower simvastatin concentrations (0.1 and 1 muM), the combination of statin and unidirectional steady or pulsatile...
Therapeutic Effects of Marine Collagen Peptides on Chinese Patients With Type 2 Diabetes Mellitus and Primary Hypertension.
CONCLUSIONS:: MCPs supplement may benefit glucose and lipid metabolism, insulin sensitivity, renal function and hypertension management in Chinese patients with T2DM and hypertension.
PMID: 20739874 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
JUPITER: Statin therapy effective in intermediate-risk, high-CRP patients
When stratified by the underlying level of absolute risk, JUPITER patients with elevated CRP levels and a 5% to 20% 10-year risk of cardiovascular disease benefited from statin therapy, report...
For complete story visit theheart.org. (Source: theHeart.org)
Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian population
Conclusion: The association found in this study between allele E2 and lower total cholesterol level had been reported in previous studies. We have also observed that the frequency of genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol (P=0.003 OR 2.4 95% CI; 1.3-4.6). Our data needs to be repeated in a larger population with more information for serum LDL and HDL levels and their subgroups. (Source: Journal of Postgraduate Medicine)
Statins: Cost analysis in Indian scenario from eight major clinical trials
Conclusion: Cost associated with the use of statins is higher in primary prevention as compared to secondary prevention. More studies are needed to confirm the cost-effectiveness of statins to make any decision for health policy. (Source: Journal of Postgraduate Medicine)
In Reply To ?Dialysis Delivery in Canada and the United States?
We appreciate the opportunity to respond to the very important issues raised by Drs Parker, Steinman, and Glassock. Disappointingly, addressing easily measurable and actionable ?low-hanging fruit,? such as adequacy of dialysis, anemia management, and vascular access, has failed to produce a substantial improvement in the mortality outcome measures that Parker et al describe. The explanation for this disconnect is not clear, but likely is related to the fact that mortality in dialysis patients is multifactorial, and producing small but significant improvements in only a handful of risk factors does not have the same impact as it does in more ?normal? populations in which, for example, the use of statins decreases coronary events. (Source: American Journal of Kidney Diseases)
Additional
Resources
Roles Fulfilled By Cholesterol Blockers
By Groshan Fabiola
Cholesterol is a fatty, wax-like substance normally produced by liver, substance which has an important role in maintaining one’s overall health by assisting in a series of cellular processes. While Read more...
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Additional Resources
How Safe Is Your Heart?
By Christy
The level of CRP increases dramatically in case of an inflammation and could thus be used to indicate an inflammation of an artery Read more...
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