Arthritis

joints, hand or some other joint problem? But more importantly, were there any herbal remedies for or just drugs for the pain? I have heard that for joint pain glucosamine has been effective and it could be used for hand arthritis. Research shows that glucosamine is actually a component of cartilage and the body uses it to repair and rebuild the cartilage. Another commonly used dietary supplement is Glucosamine Chondroitin for symptoms and other similar joint problems. It took a bit of time and research to figure out exactly what I needed to do to resolve my joint pain. But to me it was well worth the time and effort that I spent.

No one should have to endure joint ache. There are solutions that don’t require drugs. There are exercises, all natural pain relievers, glucosamine chondroitin, creams and other herbal remedies. Many of the current books on joint problems cite the latest research in causes of joint pain and the wide array of medical and alternative medicine options available to you in the treatment of joint problems. You may need to narrow down the cause of your joint ache or pains because there are over 300 different kinds of problems one can have with joints. Your best solutions for those life interrupting joint problems is not going to be drugs, always start with the natural supplements and herbal remedies.

So if you have any joint problems go to www.ToBe-Healthy.com/forarthritis/ for the non-drug solution I use.I have a short concise e-Book “Arthritis – What You Should Know” I’m giving away free for now. Go Here www.wowgreathealth.com/free/ebook.htm for free e-Book.Cassandra Lee

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Rheumatoid Arthritis Linked to Interstitial Lung Disease
Patients with rheumatoid arthritis are at increased risk for interstitial lung disease, which significantly impacts their survival, researchers report in the February 12th online issue of Arthritis and Rheumatism. Reuters Health Information (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints
Conclusion DKK1 influences inflammatory remodelling of sacroiliac joints by prevention of joint ankylosis. This may indicate an important role of the Wnt signalling pathway in the structural bone changes of axial joint disease. Although this model does not reflect the entire spectrum of ankylosing spondylitis in humans, it helps to explain the pathophysiological processes of sacroiliac joint ankylosis, which is a hallmark of the spondyloarthritides. (Source: Annals of the Rheumatic Diseases)
Genetic control of leucocyte--endothelial cell interaction in collagen-induced arthritis
Conclusion The study describes for the first time QTL controlling the CIA initiating leucocyte&ndash;endothelial cell interaction. (Source: Annals of the Rheumatic Diseases)
Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
Conclusions Th17-related cytokines are expressed in joints of spondyloarthritis as well as RA patients. IL-23 levels, however, correlate with disease activity parameters in RA only. These results point towards a differential regulation of the Th17 cytokine system in spondyloarthritis compared with RA. (Source: Annals of the Rheumatic Diseases)
Relationship between the clinical response to adalimumab treatment and serum levels of adalimumab and anti-adalimumab antibodies in patients with psoriatic arthritis
(Source: Annals of the Rheumatic Diseases)
Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial)
Conclusion Abatacept delayed progression of UA/very early RA in some patients. An impact on radiographic and MRI inhibition was seen, which was maintained for 6 months after treatment stopped. This suggests that it is possible to alter the progression of RA by modulating T-cell responses at a very early stage of disease. Trial registration number NCT00124449. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis
Conclusions Renal dysfunction in RA is quite common and associates with classic cardiovascular risk factors such as advanced age and dyslipidaemia, levels of SUA and the presence of extra-articular disease. Renal dysfunction was not related to other RA-related factors including disease activity and duration, disability and past or present use of nephrotoxic medications. (Source: Annals of the Rheumatic Diseases)
Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR)
Conclusion The rate of TB in patients with RA treated with anti-TNF therapy was three- to fourfold higher in patients receiving INF and ADA than in those receiving ETA. (Source: Annals of the Rheumatic Diseases)
Impact of comorbidity on physical function in patients with rheumatoid arthritis
Conclusion Physical disability becomes worse with increasing levels of comorbidity, irrespective of disease activity. (Source: Annals of the Rheumatic Diseases)
Evaluation of the appropriateness of composite disease activity measures for assessment of psoriatic arthritis
Conclusion Among the currently available indices used in arthritic conditions, the DAREA best reflects the domains found to be important in PsA. (Source: Annals of the Rheumatic Diseases)
Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
Conclusions Genetic markers in the 6q23 region and TRAF1-C5 are associated with rheumatoid arthritis, in particular with positive anti-CCP and RF profile. With the exception of rs6920220, which shows highly consistent results, other proposed markers have high between-study heterogeneity that may reflect unrecognised phenotypic or genetic variability (eg, gene environment interactions) within rheumatoid arthritis. Furthermore, these markers may not be the true causative loci but rather be in linkage disequilibrium with the true ones. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis
Conclusions These data associate the 6q23 region with the rate of joint destruction in ACPA+ RA. (Source: Annals of the Rheumatic Diseases)
Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial
Conclusion In autoantibody-positive patients with arthralgia, dexamethasone treatment decreases ACPA and IgM-RF levels, but does not prevent arthritis development. Trial registration number: ISRCTN73232918. (Source: Annals of the Rheumatic Diseases)
Follow-up standards and treatment targets in rheumatoid arthritis: results of a questionnaire at the EULAR 2008
Conclusion These results suggest the acceptance of ambitious treatment concepts in practice. Although voluntary surveys have limitations, the answers reflect widespread adoption of desirable standards of care. (Source: Annals of the Rheumatic Diseases)
Ankylosing spondylitis: a risk factor for myocardial infarction?
Conclusions These observations indicate that the prevalence of MI is increased in patients with AS. (Source: Annals of the Rheumatic Diseases)
ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
Conclusions This is first confirmation in a non-Caucasian population that genetic polymorphisms in ARTS1 are associated with AS, implicating common pathogenetic mechanisms in Korean and Caucasian patients with AS. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
When does rheumatoid arthritis start and can it be stopped before it does?
(Source: Annals of the Rheumatic Diseases)
Genetic influences modulating the radiological severity of rheumatoid arthritis
This review focuses on the contribution of genetic markers to the severity of radiological damage in rheumatoid arthritis (RA). Currently available biomarkers of more severe disease include elevated erythrocyte sedimentation rates or C-reactive protein levels and rheumatoid factor (RF) or anticyclic citrullinated protein antibodies positivity; however, these biomarkers explain a relatively modest proportion of the variance in radiological damage. An important role of genetic factors on RA severity has recently emerged but studies to date have generally been of low statistical power and many have not been replicated. Genetic markers have a number of advantages over conventional biomarkers; genotypes are stable, measurable at disease onset, remain unchanged by treatment and are amenable to h...
Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study
Conclusion In patients with arthralgia the presence of ACPA (but not of IgM-RF or SE) predicts arthritis development. The risk in ACPA-positive patients may be further increased by the concomitant presence of IgM-RF or high levels of ACPA. (Source: Annals of the Rheumatic Diseases)
The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis
Conclusions Neither remission nor development of RA is delayed by GC treatment. Remission is rare in the first year of very early arthritis, occurring in &lt;20% of the patients. Also, the need to start DMARDs was not influenced by GC treatment. (Source: Annals of the Rheumatic Diseases)
Beneficial effects of a 3-week course of intramuscular glucocorticoid injections in patients with very early inflammatory polyarthritis: results of the STIVEA trial
Conclusion Treatment of patients with very early IP with IM methylprednisolone acetate appears to postpone the prescription of DMARDs and prevent one in 10 patients from progressing into RA. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
UNC Helps Establish The First National Public Health Agenda For Osteoarthritis
Betty Isaacs of Boone, N.C., knows all about the chronic pain of osteoarthritis and the impact it has on her life. "The pain in my knee was so bad, I would just sit around," Isaacs said. Last year, Isaacs participated in the Walk with Ease program administered through the UNC Thurston Arthritis Research Center and developed by the Arthritis Foundation. Walk With Ease is designed to help participants develop a walking plan, stay motivated and learn to exercise safely. "This was a real meaningful program for me," said Isaacs, who has knee OA and was overweight... (Source: Health News from Medical News Today)
UNC Helps Establish The First National Public Health Agenda For Osteoarthritis
Betty Isaacs of Boone, N.C., knows all about the chronic pain of osteoarthritis and the impact it has on her life. "The pain in my knee was so bad, I would just sit around," Isaacs said. Last year, Isaacs participated in the Walk with Ease program administered through the UNC Thurston Arthritis Research Center and developed by the Arthritis Foundation... (Source: Bones / Orthopaedics News From Medical News Today)
Knee replacement in elderly patients shown to improve balance
(American Academy of Orthopaedic Surgeons) Total knee replacement (TKR) successfully relieves pain and improves function in patients with advanced knee arthritis, according to a study presented today at the 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). (Source: EurekAlert! - Medicine and Health)
MRC scientists announce advance in understanding body's natural defenses
(University of Leicester) Medical Research Council scientists at the University of Leicester have made a new advance in understanding how the body fights certain types of cancer and other disease such as lupus and rheumatoid arthritis. (Source: EurekAlert! - Medicine and Health)
Advance in understanding body?s natural defenses
New research offers potential for developing new therapies for lupus, rheumatoid arthritis and certain types of cancer. (Source: ScienceDaily Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Olde Westport Spice Announces a Voluntary Recall of Garden Harvest Special Blend Seasoning
Olde Westport Spice announced that it is voluntarily recalling 5- and 10-oz. jars and 20-oz. bags of Garden Harvest Special Blend Seasoning because an ingredient used in the product has the potential to be contaminated with Salmonella. Salmonella is an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems.Healthy persons infected with Salmonella often experience fever, diarrhea (which may be bloody), nausea, vomiting and abdominal pain. In rare circumstances, infection with Salmonella can result in the organism getting into the bloodstream and producing more severe illnesses such as arterial infections (i.e., infected aneurysms), endocarditis and arthritis. (Source: Food and Drug Administration)
Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis.
Conclusions: Gait analysis allows for pinpointing the initial inflammatory changes in experimental arthritis models such as pristane-induced arthritis. Analysis of early clinically relevant symptoms in arthritis models may facilitate the search for novel therapeutics to interfere with pain, inflammation and joint destruction in patients suffering from inflammatory arthritis. (Source: BioMed Central)
Roche and Biogen Idec decide to suspend Ocrelizumab treatment
Roche and Biogen Idec announced their decision to suspend Ocrelizumab treatment of patients in the Rheumatoid Arthritis (RA) programme. The decision follows the recommendation of the independent Ocrelizumab RA & Lupus Data and Safety Monitoring Board (DSMB) based on their assessment of the studies in RA (SCRIPT, FEATURE, FILM and STAGE) and lupus (BELONG and BEGIN). (Source: World Pharma News)
A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis
Authors: P G Bronson, P P Ramsay, M F Seldin, P K Gregersen, L A Criswell & L F Barcellos (Source: Genes and Immunity)
Pharmacogenetics in treatment of rheumatoid arthritis.
Authors: Kooloos WM, Huizinga TW, Guchelaar HJ, Wessels JA Over the last decades important progress is being made regarding disease modifying anti-rheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA). Nevertheless, a substantial part of the patients fail to achieve a good response and/or experience toxicity, which limits further treatment leading to progression of inflammation and destruction of joints. These high interindividual differences in drug response gave rise to the need for prognostic markers in order to individualize and optimize therapy with these antirheumatic agents. Besides demographic and clinical factors, studies in the research field of pharmacogenetics have reported potential markers associated with clinical response on treatment with methotrexate a...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Anti-TNF Therapy Improves Life with Psoriatic Arthritis (CME/CE)
Treatment with anti-tumor necrosis factor (TNF) agents can significantly improve physical disability and quality of life for patients with psoriatic arthritis, data from an observational study showed (Source: MedPage Today Rheumatology)
Adult pain linked to childhood bad behaviour
Badly behaved children more likely to have adult chronic painRelated items from OnMedicaRCN will appeal if rheumatoid arthritis drug is restricted Regular tipple may halve risk of rheumatoid arthritisHeavy babies risk rheumatoid arthritis in adulthoodChaperonesBereavement (Source: OnMedica Latest News)
Effects of Long-Term Disease-Modifying Antirheumatic Drugs on Endothelial Function in Patients with Early Rheumatoid Arthritis
Rheumatoid arthritis (RA) is associated with enhanced atherosclerosis and impaired endothelial function early after the onset of the disease and cardiovascular (CV) disease represents one of the leading causes of morbidity and mortality. It is well known that disease modifying antirheumatic drugs (DMARDs) are able to improve the course of the disease and the quality of life of these patients, but little is known about the effects of DMARDs on CV risk and endothelial dysfunction. Our goal was to examine the effects of long-term therapy with DMARDs on endothelial function and disease activity in early RA (ERA). Twenty-five ERA patients (mean age 52 ± 14.6 years, disease duration 6.24 ± 4.10 months) without evidence of CV involvement were evaluated for disease activity score (DAS-28), 2D-ec...
Pathophysiology of TMD pain &#x2013; basic mechanisms and their implications for pharmacotherapy
This article discusses the pathophysiology of temporomandibular disorders (TMD)-related pain and its treatment with analgesic drugs. Temporomandibular disorders are comprised of a group of conditions that result in temporomandibular joint pain (arthralgia, arthritis) and/or masticatory muscle pain (myofascial TMD). In at least some patients with TMD, a peripheral mechanism contributes to this pain. However, there is often a poor correlation between the severity of TMD-related pain complaints and evidence of definitive tissue pathology. This has led to the concept that pain in some patients with TMD may result from altered central nervous system pain processing and further that this altered pain processing may be attributable to specific genes that are heritable. Psychosocial stressors are ...
Medication Fears Lead to Worse Side Effects
It may not be surprising, but a new study offers some proof that patients who are worried about their medications are more likely to have side effects from them.Source: Reuters Health Related MedlinePlus Pages: Medicines, Rheumatoid Arthritis (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Early syphilis mimicking tuberculous meningoencephalitis in an HIV-positive patient
A man previously treated for tuberculous arthritis presented with acute meningoencephalitis. Cerebrospinal fluid tests suggested infection with Mycobacterium tuberculosis, but a diagnosis of early neurosyphilis was subsequently made. (Source: International Journal of STD and AIDS)
Long-Term Abatacept Safe, Usually Effective for Juvenile Idiopathic Arthritis
Four out of five children with juvenile idiopathic arthritis had a good clinical response to abatacept during a long-term open-label extension trial. The safety profile was good, and the level of response often increased as treatment went on, the researchers report. Reuters Health Information (Source: Medscape Medical News Headlines)
Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis [Immunology]
There is increasing appreciation of the important role of B cells in many autoimmune diseases and consequently, increasing interest in... (Source: Proceedings of the National Academy of Sciences)
New Biologic for Treating Rheumatoid Arthritis: Clinical Trial Experience With Tocilizumab
Tocilizumab, the first IL-6 receptor antagonist, has demonstrated efficacy in patients with moderate to severe RA refractory to anti-TNF therapy. International Journal of Clinical Rheumatology (Source: Medscape Rheumatology Headlines)
Growth retardation and delayed puberty in children and adolescents with juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is the most common joint disorder in developing children. Juvenile idiopathic arthritis is difficult to diagnose and treat. In some patients, signs and symptoms can be frustratingly inconsistent, contradictory or idiosyncratic. Short stature in patients with JIA is usually due to reduced growth in the lower extremities, and only rarely due to reduced growth in the spinal column. In some studies, children with JIA were found to have infantile body proportions. Puberty is delayed in children with JIA. In children with chronic arthritic disorders, there is a strong correlation between the activity of the disease and the age of puberty. The main goals in reducing growth retardation in children with JIA are promoting timely remission and reducing the duration...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Low prevalence of anti-RNA polymerase III antibodies in a French scleroderma population Anti-RNA polymerase III scleroderma.
CONCLUSIONS: Anti-RNAP III was rarely detected in a French population of SSc patients. Their prevalence was even lower than the one observed in rheumatoid arthritis controls. Therefore local immunologic profiles should be established before deciding a change in clinical practice for SSc immune screening. PMID: 20206882 [PubMed - as supplied by publisher] (Source: European Journal of Internal Medicine)
Free radical scavenging activity of
Rathod N R, Raghuveer I, Chitme H R, Chandra RIndian Journal of Pharmaceutical Sciences 2009 71(6):615-621Swarnabhasma , an Ayurvedic preparation containing Calotropis gigantea R. Br. (Asclepiadaceae) is extensively used by Ayurvedic physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report the effect of chloroform extracts of Calotropis gigantea leaf and flower on free radical scavenging activity, and lipid profile in streptozotozin-induced diabetic rats. The lipid peroxidation, superoxide dismutase, and catalase were measured in liver homogenate and serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, lipid profile were measured in blood serum. Administration ...
No Survival Improvement in RA (CME/CE)
Despite decades of dramatic advances in treatment of rheumatoid arthritis, survival has not improved for these patients, a Dutch study found. (Source: MedPage Today Geriatrics)
Revolutionary hip operation that's left patients crippled for life
It's supposed to be the cutting edge answer to arthritis. But as this shocking report reveals, hip resurfacing can wreak havoc with your body. (Source: the Mail online | Health)
Comparison of hyaluronan effects among normal, osteoarthritis, and rheumatoid arthritis cartilages stimulated with fibronectin fragment.
This study was aimed to compare the inhibitory effects of HA on nitric oxide (NO) production by COOH-terminal heparin-binding fibronectin fragment (HBFN-f) between normal and diseased cartilages. When articular cartilage explants from normal, OA, or RA joints were incubated with HBFN-f, the RA and OA cartilages produced higher levels of NO compared with normal cartilage. Pretreatment with 2700 kDa HA resulted in significant suppression of HBFN-f-stimulated NO production in OA and RA cartilages. While CD44 was up-regulated in OA and RA cartilages, anti-CD44 antibody reversed HA inhibition of HBFN-f action in those cartilages. The present results clearly demonstrated that HA blocked HBFN-f actions in OA and RA cartilages through interaction with CD44. HA, which targets CD44 highly expressed ...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Hyaluronan Inhibits Prostaglandin E(2) Production via CD44 in U937 Human Macrophages.
This study was aimed to investigate the inhibitory mechanism of HA on lipopolysaccharide (LPS)-stimulated PGE(2) production in U937 human macrophages. Stimulation of U937 macrophages with LPS enhanced PGE(2) production in association with increased protein levels of cyclooxygenase-2 (COX-2). Pretreatment with HA of 2,700 kDa resulted in suppression of the LPS-mediated induction of COX-2, leading to a decrease in PGE(2) production. Likewise, the LPS-stimulated PGE(2) production was inhibited by the pretreatment with a specific COX2 inhibitor, NS-398, or a specific inhibitor of nuclear factor (NF)-kappaB, BAY11-7085. HA also decreased the degree of phosphorylation and nuclear translocation of NF-kappaB enhanced by LPS. Fluorescence cytochemistry demonstrated that HA bound to CD44, the princi...
Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System.
Authors: Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M Enzyme-linked immunosorbent assays (ELISA) have been widely used to determine quantitatively autoantibodies. However, the processes for the purification and immobilization of antigens in conventional ELISA methods include multiple steps, which have hampered the application for screening of autoantibodies. Here, we have developed a novel ELISA system using the plates pre-coated with glutathione casein to capture recombinant proteins fused to N-terminal glutathione S-transferase (GST). The GST-fused proteins were synthesized with the wheat germ cell-free protein production system. Thus, the present system combined the GST-capture ELISA with the cell-free...
Treating Psoriasis If Enbrel Fails
Title: Treating Psoriasis If Enbrel FailsCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/9/2010 10:10:12 AM (Source: MedicineNet Arthritis General)
Thumb arthritis: Self-care measures can ease pain
Thumb arthritis &mdash; Comprehensive overview covers symptoms, treatment of osteoarthritis in your basal (carpometacarpal) joint. (Source: MayoClinic.com Full Feed)
Arthritis: Side Effect-Free Treatment
(Ivanhoe Newswire) -- Electromagnetic pulses were found to significantly decrease pain and inflammation associated with osteoarthritis of the knee. (Source: Medical Headlines From Ivanhoe.com)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells
Conclusion: These data show that a proapoptotic fibronectin matrix induces ubiquitination and degradation of p53 in the proteasome as part of a novel mechanism of apoptosis associated with inflammatory diseases. (Source: Journal of Periodontal Research)
Investigational rheumatoid arthritis treatment ocrelizumab suspended following safety concerns
Source: Reuters Health Area: News Roche and Biogen are suspending their experimental rheumatoid arthritis and lupus treatment ocrelizumab following reports of serious infections in studies and some fatalities. Roche will be examining the data to gain an increased understanding of the causes of the infections. Ocrelizumab was expected to succeed rituximab when its patent expired and Roche had announced in 2009 that a late-stage trial showed that it reduced the signs and symptoms of rheumatoid arthritis, but was associated with a higher number of serious infections. Ocrelizumab is still being evaluated for relapsing remitting multiple sclerosis and a phase II study is on-going. (Source: NeLM - News)
Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests
IntroductionAnalysis of autoantibodies (AAB) by indirect immunofluorescence (IIF) is a basic tool for the serological diagnosis of systemic rheumatic disorders. Automation of AAB IIF reading including pattern recognition may improve intra- and inter-laboratory variability and meet the demand for cost-effective assessment of large numbers of samples. Comparing automated and visual interpretation, the usefulness for routine laboratory diagnostics was investigated. Methods: Autoantibody detection by IIF on human epithelial-2 (HEp-2) cells was conducted in a total of 1222 consecutive sera of patients with suspected systemic rheumatic diseases from a university routine laboratory (n=924) and a private referral laboratory (n=298). IIF results from routine diagnostics were compared with a novel a...
Developments in the Scientific and Clinical Understanding of Fibromyalgia
Research over the past decade has yielded significant progress in understanding fibromyalgia. Arthritis Research & Therapy (Source: Medscape Rheumatology Headlines)
56. The effect of pain on cognitive abilities of patients with rheumatoid arthritis
The aim was to examine the impact of the pain on the cognitive abilities in the patients with rheumatoid arthritis (RA). Material and methods: we investigated 60 patients with RA and 30 healthy subjects. The intensity of pain was determined by VAS, cognitive abilities by the Wechsler memory scale, functional ability by HAQ questionnaire, and disease activity by DAS28 score. (Source: Clinical Neurophysiology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
57. Anxiety in the patients with rheumatoid arthritis
The aim was to identify the frequency and level of anxiety in the patients with rheumatoid arthritis (RA). In 60 patients with RA, aged 49.87±7.56 yrs., we evaluated: disease activity by DAS28 score, functional ability by the HAQ, and anxiety by Spielberger test (state and trai anxiety). (Source: Clinical Neurophysiology)
Roche, Biogen stop arthritis drug program
Roche and Biogen Idec pulled the plug on a late-stage rheumatoid arthritis treatment program after a review panel found sometimes-fatal infections. (BIIB) (Source: bizjournals.com Health Care:Biotechnology headlines)
Roche, Biogen suspends arthritis drug after deaths
ZURICH (Reuters) - Swiss drugmaker Roche Holding AG and U.S. biotechnology company Biogen Idec are suspending experimental rheumatoid arthritis and lupus treatment ocrelizumab after deaths following its use, casting doubt over its future. (Source: Reuters: Health)
NicOx announces FDA Advisory Committee to discuss naproxcinod on May 12
Sophia Antipolis, France, March 8, 2010. -NicOx S.A. today announces that on Wednesday, May 12, 2010, the US Food and Drug Administration (FDA) plans to hold a meeting of the Arthritis Drugs Advisory Committee and the Drug Safety and Risk... (Source: Drugs.com - New Drug Applications)
Roche, Biogen suspend arthritis drug after deaths
ZURICH (Reuters) - Swiss drugmaker Roche Holding AG and U.S. biotechnology company Biogen Idec are suspending rheumatoid arthritis and lupus treatment ocrelizumab after it caused deaths, casting doubt over the drug's future. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Roche Suspends Arthritis Drug Study After Deaths
From Associated Press (March 8, 2010) &nbsp; BASEL, Switzerland -- Swiss pharmaceutical company Roche Group said Monday it has suspended a late-stage trial for a new rheumatoid arthritis and lupus drug after several patients died from... (Source: Drugs.com - Pharma News)
Arthritis drug development halted
Development of a drug used to treat arthritis has been halted by Roche and Biogen. (Source: Pharmacy Europe)
Roche and Biogen Idec Decide to Suspend Ocrelizumab Treatment - Rheumatoid Arthritis Development Programme on Hold
Future of the Ocrelizumab RA clinical programme under evaluation Basel, Switzerland,&nbsp;March 8,&nbsp;2010--Roche and Biogen Idec announced today their decision to suspend Ocrelizumab treatment of patients in the Rheumatoid Arthritis (RA)... (Source: Drugs.com - Pharma News)
Pain Relief For Osteoarthritis Provided By Electromagnetic Pulses
Electromagnetic pulses significantly decrease pain and inflammation associated with osteoarthritis of the knee, according to Henry Ford Hospital researchers... (Source: Pain / Anesthetics News From Medical News Today)
Pain Relief For Osteoarthritis Provided By Electromagnetic Pulses
Electromagnetic pulses significantly decrease pain and inflammation associated with osteoarthritis of the knee, according to Henry Ford Hospital researchers. In the double-blind, randomized placebo-controlled study, 34 patients used a portable battery-operated device that emits a low-intensity pulsating electromagnetic frequency and experienced more than 40 percent pain relief on their first day. "Our results show pulsed electromagnetic fields caused a significant decrease in pain" says Fred Nelson, M.D... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Experimental Vaccine Protects Monkeys Against Chikungunya
Imagine a mosquito-borne virus that has already infected millions of people in recent outbreaks in South and Southeast Asia, the islands of the Indian Ocean, Africa and northern Italy. Although seldom fatal, it causes highly painful arthritis-like symptoms that can linger for months or even years. It's capable of adapting to spread through a mosquito species common in much of North America. And no vaccine or treatment exists to protect humans from its effects. The scenario may sound like something dreamed up as a training exercise by public health authorities, but the virus is all too real... (Source: Health News from Medical News Today)
Experimental Vaccine Protects Monkeys Against Chikungunya
Imagine a mosquito-borne virus that has already infected millions of people in recent outbreaks in South and Southeast Asia, the islands of the Indian Ocean, Africa and northern Italy. Although seldom fatal, it causes highly painful arthritis-like symptoms that can linger for months or even years. It's capable of adapting to spread through a mosquito species common in much of North America... (Source: Immune System / Vaccines News From Medical News Today)
Electromagnetic Pulses May Stem Arthritic Knee Pain
Title: Electromagnetic Pulses May Stem Arthritic Knee PainCategory: Health NewsCreated: 3/6/2010 12:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Chronic Pain General)
Electromagnetic Pulses May Stem Arthritic Knee Pain
Title: Electromagnetic Pulses May Stem Arthritic Knee PainCategory: Health NewsCreated: 3/6/2010 12:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Senior Health General)
Electromagnetic Pulses May Stem Arthritic Knee Pain
Title: Electromagnetic Pulses May Stem Arthritic Knee PainCategory: Health NewsCreated: 3/6/2010 12:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Roche And Biogen Idec Decide To Suspend Ocrelizumab Treatment - Rheumatoid Arthritis Development Programme On Hold
Roche and Biogen Idec announced recently their decision to suspend Ocrelizumab treatment of patients in the Rheumatoid Arthritis (RA) programme. (Source: Pharmaceutical Online News)
Roche and Biogen Idec decide to suspend Ocrelizumab treatment - Rheumatoid Arthritis development programme on hold
Roche and Biogen Idec announced today their decision to suspend Ocrelizumab treatment of patients in the Rheumatoid Arthritis (RA) programme. (Source: Roche Media News)
Roche and Biogen Idec decide to suspend Ocrelizumab treatment - Rheumatoid Arthritis development programme on hold
Roche and Biogen Idec announced today their decision to suspend Ocrelizumab treatment of patients in the Rheumatoid Arthritis (RA) programme. (Source: Roche Investor Update)
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
IntroductionSurfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA. Methods: One-hundred-and-sixty DMARD naive RA patients with disease duration less than 6 months were studied prospectively for 4 years (CIMESTRA trial) including disease activity measures (C-reactive protein, joint counts and Health Ass...
Electromagnetic pulses may ease osteoarthritis pain
A battery-operated device that emits electromagnetic pulses could provide significant pain relief to people with osteoarthritis of the knee, scientists have claimed. (Source: Arthritis Research Campaign)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
SMC does not recommend ketoprofen/omeprazole (Axorid®) for rheumatoid arthritis, ankylosing spondylitis and osteoarthritis
Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) does not recommend ketoprofen/omeprazole (Axorid®) for use within NHS Scotland for the symptomatic treatment of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in patients with a previous history or who are at risk of developing NSAID associated gastric ulcers, duodenal ulcers and gastroduodenal erosions in whom continued treatment with ketoprofen is essential. &nbsp; The drug advice notes that the manufacturer did not present a sufficiently robust economic analysis to gain acceptance by the SMC.&nbsp; The licence holder has indicated their intention to resubmit.&nbsp; Please see the link below for details. (Source: NeLM - Drug Specific Reviews)
Feasibility and Outcomes of a Home-Based Exercise Program on Improving Balance and Gait Stability in Women With Lower-Limb Osteoarthritis or Rheumatoid Arthritis: A Pilot Study. - Williams SB, Brand CA, Hill KD, Hunt SB, Moran H.
OBJECTIVE: To evaluate the feasibility and gait stability and balance outcomes of a 4-month individualized home exercise program for women with arthritis. DESIGN: Pre-post interventional study. SETTING: General community. PARTICIPANTS: Women (N=49) (volunt... (Source: SafetyLit: All (Unduplicated))
Studies Detail Possible Benefits Of Omega-3 Fatty Acids For Dogs With Arthritis
A series of studies published in the Journal of the American Veterinary Medical Association (JAVMA) offers new insights into the possible benefits derived from feeding foods containing high omega-3 fatty acid concentrations to dogs with osteoarthritis. The results of the three studies, according to contributing author Dr. Kevin Hahn, director of research and chief medical officer at Hill's Pet Nutrition Inc., show that the dogs that were fed the foods experienced less pain associated with the disease and greater mobility... (Source: Health News from Medical News Today)
Studies Detail Possible Benefits Of Omega-3 Fatty Acids For Dogs With Arthritis
A series of studies published in the Journal of the American Veterinary Medical Association (JAVMA) offers new insights into the possible benefits derived from feeding foods containing high omega-3 fatty acid concentrations to dogs with osteoarthritis. The results of the three studies, according to contributing author Dr... (Source: Veterinary News From Medical News Today)
Electromagnetic Pulses May Stem Arthritic Knee Pain
New device could improve life quality without side effects, expert says Source: HealthDay Related MedlinePlus Pages: Knee Injuries and Disorders, Osteoarthritis (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
UCB Rheumatoid Arthritis Family Scholarship Deadline
Applications are being accepted until March 19, 2010 for the UCB Rheumatoid Arthritis Family Scholarship. (Source: Disabled World)
Early Combination Therapy Best in RA (CME/CE)
Combination therapy with methotrexate and the tumor necrosis factor inhibitor etanercept (Enbrel) provided significantly greater clinical and radiographic benefits in early rheumatoid arthritis than treatment with methotrexate alone, an international double-blind study confirmed. (Source: MedPage Today Geriatrics)
We Must No Longer Ignore the Cruelty of Our Eating (Opinion)
(NaturalNews) The more forcefully we ignore something, the more power it has over us and the more strongly it influences us. Taking a clear look at the foods produced by modern methods and what we have been conditioned to accept, we find misery, cruelty and exploitation. Therefore, we avoid looking deeply at our food, if of animal origin, and continue floating in that big river in Egypt (the Nile). This practice of avoidance and denial, applied to eating, carries over automatically into our entire private and public life. We know, deep down, that we cannot look deeply anywhere. If we do, we will have to look deeply into the enormous suffering our food choices directly cause.So, we learn to stay shallow and to be willingly blind to the connections we see. Otherwise, our remorse and guilt wo...
Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran.
Authors: Hashemi M, Moazeni-Roodi AK, Fazaeli A, Sandoughi M, Bardestani GR, Kordi-Tamandani DM, Ghavami S Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 healthy subjects was determined using tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment length polymorphism (RFLP) methods. We found no significant differences between rheumatoid arthritis patients and control subjects regarding PON1 Q19...
McCormick & Company Initiates Recall Due to Possible Health Risk from HVP Ingredient
McCormick & Company, Incorporated (NYSE:MKC) is initiating a recall of products manufactured with HVP (hydrolyzed vegetable protein) supplied by Basic Food Flavors of Las Vegas, Nevada, because the ingredient has the potential to be contaminated with Salmonella. "Consumption of products containing Salmonella can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Healthy persons infected with Salmonella often experience fever, diarrhea (which may be bloody), nausea, vomiting and abdominal pain. In rare circumstances, infection with Salmonella can result in the organism getting into the bloodstream and producing more severe illnesses such as arterial infections (i.e., infected aneurysms) endocarditis and arthriti...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
N-(tert)-Butyloxycarbonyl)-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives.
Authors: Mollica A, Feliciani F, Stefanucci A, Cacciatore I, Cornacchia C, Torino D, Pinnen F It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimer's disease (AD), prion disease (CJD) and Parkinson's disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Also furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic beta,beta-dialkylsubstituted, fully protected, cysteine derivative as a suitable inter...
[Rheumatoid arthritis and autoimmune hemolysis : B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease.]
We report on a 68-year-old female patient with established, long-standing rheumatoid arthritis, who complained of progressive weakness and worsening of her arthralgia under therapy with leflunomide. Physical and laboratory examination revealed autoimmune hemolysis due to cold agglutinin disease. As hemolysis and arthritis were refractory to steroid treatment, B-cell depletion with rituximab was performed leading to a marked reduction of hemolytic parameters as well as remission of her rheumatoid arthritis. PMID: 20213090 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)
Hydroxychloroquine for Rheumatoid Arthritis, Lupus Linked to Retinopathy
In patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), long-term hydroxychloroquine therapy increases the risk of retinopathy, according to a February 12th online publication in Arthritis Care & Research. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Merck "could face 500 Vioxx claims"
US pharmaceutical giant Merck could be bracing itself for hundreds of lawsuits in Australia after a judge ruled its arthritis drug Vioxx doubled the risk of a heart attack. (Source: Pharmacy Europe)
Epidemiology, clinical manifestations, and diagnosis of chikungunya fever: Lessons learned from the re-emerging epidemic
Mohan Alladi, Kiran D.H.N, Manohar I Chiranjeevi, Kumar D PrabathIndian Journal of Dermatology 2010 55(1):54-63Chikungunya fever, caused by &#x0026;amp;quot;Chikungunya virus,&#x0026;amp;quot; is an arbovirus disease transmitted by the bite of infected mosquitoes belonging to the genus &#x0026;lt;i&#x0026;gt;Aedes&#x0026;lt;/i&#x0026;gt;. Chikungunya fever epidemics have been reported from several countries around the world. The disease that was silent for nearly 32 years re-emerged in the October 2005 outbreak in India that is still ongoing. The incubation period ranges from 3 to 12 days. The onset is usually abrupt and the acute stage is characterized by sudden onset with high-grade fever, severe arthralgias, myalgias, and skin rash. Swollen tender joints and crippling arthritis are usua...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Mucocutaneous manifestations of Chikungunya fever
Bandyopadhyay Debabrata, Ghosh Sudip KumarIndian Journal of Dermatology 2010 55(1):64-67Chikungunya fever (CF) is an arboviral acute febrile illness transmitted by the bite of infected &#x0026;lt;i&#x0026;gt;Aedes&#x0026;lt;/i&#x0026;gt; mosquitoes. After a quiescence of more than three decades, CF has recently re-emerged as a major public health problem of global scale. CF is characterized by an acute onset of high fever associated with a severe disabling arthritis often accompanied by prominent mucocutaneous manifestations. The disease is usually self-limiting, but the joint symptoms and some of the cutaneous features may persist after the defervescence. A wide range of mucocutaneous changes has been described to occur in association with CF during the current epidemic. Besides a morbill...
Inflammatory Bowel Disease Serologies in Ankylosing Spondylitis Patients: A Pilot Study
Mucosal dysregulation may play a significant role in ankylosing spondylitis, according to this pilot study. Arthritis Research & Therapy (Source: Medscape Today Headlines)
Salmonella Scare Prompts Wide Product Recall
Title: Salmonella Scare Prompts Wide Product RecallCategory: Health NewsCreated: 3/4/2010 8:10:00 PMLast Editorial Review: 3/5/2010 (Source: MedicineNet Arthritis General)
Certain Bone Drugs May Lower Breast Cancer Risk
Title: Certain Bone Drugs May Lower Breast Cancer RiskCategory: Health NewsCreated: 3/5/2010 10:10:00 AMLast Editorial Review: 3/5/2010 (Source: MedicineNet Arthritis General)
NICE Asks For More Data On New Drug For Rheumatoid Arthritis
NICE's independent appraisal committee has asked Roche, the manufacturer of tocilizumab (RoActemra), a new treatment for moderate to severe active rheumatoid arthritis, for further additional information on its product. The committee is minded not to recommend the use of the drug but the additional information it has asked for today (4 March) could result in the final guidance being positive at specific stages of the treatment pathway. This draft guidance has been issued for consultation: NICE has not yet issued final guidance to the NHS... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
NICE Asks For More Data On New Drug For Rheumatoid Arthritis
NICE's independent appraisal committee has asked Roche, the manufacturer of tocilizumab (RoActemra), a new treatment for moderate to severe active rheumatoid arthritis, for further additional information on its product... (Source: Arthritis News From Medical News Today)
Topical NSAID Therapy for Musculoskeletal Pain
Conclusions. Topical NSAIDs may vary significantly in their absorption kinetics and pharmacodynamic effects, based on NSAID molecule and the formulation chosen. Some topical NSAID formulations have been shown to be more effective than placebo in multiple studies, or to have comparable efficacy and a better safety profile than oral NSAIDs for single joint osteoarthritis and acute muscle injuries. In acute and chronic low back pain, widespread musculoskeletal pain, and in peripheral neuropathic pain syndromes, the current evidence does not support the use of topical NSAIDs. (Source: Pain Medicine)
The Protective Effect of Bee Venom against Ethanol-Induced Hepatic Injury via Regulation of the Mitochondria-Related Apoptotic Pathway
In conclusion, bee venom treatment in ethanol-induced hepatocyte apoptosis occurred through the regulation of Bcl family with subsequent inactivation of the Caspase and PARP. These results suggest that bee venom could be an effective agent to reduce ethanol-induced hepatocyte apoptosis. (Source: Basic and Clinical Pharmacology and Toxicology)
[Seminar] Bacterial septic arthritis in adults
Symptoms and signs of septic arthritis are an important medical emergency, with high morbidity and mortality. We review the changing epidemiology of septic arthritis of native joints in adults, encompassing the increasing frequency of the disorder and its evolving antibiotic resistance. We discuss various risk factors for development of septic arthritis and examine host factors (tumour necrosis factor ?, interleukins 1 and 10) and bacterial proteins, toxins, and enzymes reported to be important determinants of pathogenesis in mouse models. Diagnosis of disease is largely clinical, guided by investigations and the opinion of skilled clinicians. We emphasise the need for timely medical and surgical intervention?most importantly, through diagnostic aspiration of relevant joints, choice of ...
TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis; two large longitudinal studies
Conclusions: The TRAF1/C5 region is not associated with an increased mortality risk. (Source: Arthritis Research and Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Football 'good for bone health'
Adults who play football on a regular basis are likely to benefit from improved bone health, new research suggests. (Source: Arthritis Research Campaign)
NICE requests more information on rheumatoid arthritis drug tocilizumab
The National Institute for Health and Clinical Excellence (NICE) has asked the manufacturer of a drug called tocilizumab (RoActemra) for more information on its efficacy before publishing its final guidance on the rheumatoid arthritis treatment. (Source: Arthritis Research Campaign)
NICE publishes draft guidance on rheumatoid arthritis drugs after initial anti-TNF use
The National Institute for Health and Clinical Excellence (NICE) has published preliminary recommendations on the management of rheumatoid arthritis after initial treatment with an anti-TNF drug has failed. (Source: Arthritis Research Campaign)
Fibrillary glomerulonephritis in rheumatoid arthritis
(Source: Nephrology)
Promotion of arthritis and allergy in mice by aminoglycoglycerophospholipid, a membrane antigen specific to Mycoplasma fermentans
Mycoplasmas, which lack a cell wall and are the smallest self-replicating bacteria, have been linked to some chronic diseases, such as AIDS, rheumatoid arthritis (RA), and oncogenic transformation of cells. Their membrane components (lipoproteins and glycolipids) have been identified as possible causative factors in such diseases. Glycoglycerophospholipid (GGPL)-III, a unique phosphocholine-containing aminoglycoglycerophospholipid, is a major specific antigen of Mycoplasma fermentans, and has been detected in 38% of RA patients. Unlike those of lipoproteins, which induce inflammation via Toll-like receptor 2 (TLR2), the pathologic effects of GGPL-III are poorly understood. RA and metal allergies are chronic inflammatory diseases in which autoantigens have been implicated. Here, we examined...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Just Do It to Live!
Let's face it, fad-diets and anti- aging products may seem like the answer to all the noticeable, unwanted side effects of aging. The truth is, once a man hits 40, the risk of heart disease, cancer, strokes, and arthritis increases dramatically, and... (Source: OrlandoSentinel: Medical Research)
Lancet Seminar: Bacterial septic arthritis in adults
Source: Lancet Area: News The authors of this Seminar review the changing epidemiology of septic arthritis of native joints in adults, including the increasing frequency of the disorder and its evolving antibiotic resistance. They also discuss the various risk factors for the development of this condition and the importance of timely diagnosis and management. (Source: NeLM - News)
Exploring Tai Chi in rheumatoid arthritis: a quantitative and qualitative study
Conclusions: Improved muscle function in lower limbs was also reflected when patient experiences with Tai Chi were studied in depth in this explorative study. The combination of qualitative and quantitative research methods shows that Tai Chi has beneficial effects on health not related to disease activity and standardised health status assessment, and may contribute to an understanding of how Tai Chi exerts its effects.Trial registration: NCT00522054 (Source: BMC Musculoskeletal Disorders)
Pharmacists may help to fight osteoporosis
Pharmacists could play an important role in encouraging people to take care of their bone health, new research suggests. (Source: Arthritis Research Campaign)
Rosiglitazone reduces a wide range of proinflammatory profiles in synovial fibroblast SW982 under spheroid culture.
Authors: Song JS, Kim CH, Heo JY, Cho YS Rosiglitazone (RSG) has been known to play a role in the modulation of inflammatory responses. Therefore, we sought to elucidate the underlying molecular mechanism by which RSG regulates the development of rheumatoid arthritis. Firstly, we examined the preventive effect of RSG on the inflammatory mediators induced by spheroid culture of synovial sarcoma SW982. Expression of proinflammatory cytokines under spheroid culture was more elevated than that under monolayer culture while RSG abolished inflammatory responses. The upregulation of inflammation-related genes by spheroid culture was closely associated with NFkappaB (NFkappaB) activation. Also, activation of p38 and c-Jun N-terminal kinase (JNK) by spheroid culture was abrogated with RSG treat...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.
Authors: Kim MK, Chung SW, Kim DH, Kim JM, Lee EK, Kim JY, Ha YM, Kim YH, No JK, Choi JS, Yu BP, Yokozawa T, Kim YJ, Chung HY Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on proinflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Needs experimental protocols: animal feeding and cell system. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment s...
Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis.
Authors: Auci DL, Mangano K, Destiche D, White SK, Huang Y, Boyle D, Frincke J, Reading CL, Nicoletti F HE3286 (17alpha-ethynyl-5-androstene-3beta, 7beta, 17beta-triol) is an orally bio-available synthetic derivative of naturally occurring androstene-3beta, 7beta, 17beta-triol. Our present data show that oral treatment with HE3286, favourably influenced the course of arthritis in the rat model of adjuvant-induced arthritis (reduced cumulative disease scores and paw edema), and in the mouse model of collagen antibody-induced arthritis (reduced clinical paw scores). Importantly, HE3286 was not immune suppressive in human mixed lymphocyte reaction or in animals challenged with Coxsackie B3 virus. HE3286 is currently in phase I/II clinical trials in rheumatoid arthritis and ulcerative coli...
NICE Reassessment Of Switching Decision Brings Little Hope For Rheumatoid Arthritis Patients
The National Rheumatoid Arthritis Society (NRAS) has expressed their frustration at NICE's provisional decision not to allow patients with rheumatoid arthritis to routinely switch from one Anti-TNF drug to another. This is the second time NICE has appraised the sequential effectiveness of multiple biologic therapies following NRAS's successful appeal of negative NICE guidance on switching in 2007. Over time, some patients find that whichever Anti-TNF they have been taking becomes less effective and have found benefit from being able to switch to another Anti-TNF... (Source: Health News from Medical News Today)
New 'Work Charter' Launched To Help 6.5m People With Musculoskeletal Conditions To Stay In Work, UK
Today the Arthritis and Musculoskeletal Alliance (ARMA), backed by leading policymakers and employers, is calling for positive action to ensure people with musculoskeletal disorders (MSDs) are properly supported to access employment and remain in their jobs... (Source: Health News from Medical News Today)
New 'Work Charter' Launched To Help 6.5m People With Musculoskeletal Conditions To Stay In Work, UK
Today the Arthritis and Musculoskeletal Alliance (ARMA), backed by leading policymakers and employers, is calling for positive action to ensure people with musculoskeletal disorders (MSDs) are properly supported to access employment and remain in their jobs... (Source: Bones / Orthopaedics News From Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
NICE Reassessment Of Switching Decision Brings Little Hope For Rheumatoid Arthritis Patients
The National Rheumatoid Arthritis Society (NRAS) has expressed their frustration at NICE's provisional decision not to allow patients with rheumatoid arthritis to routinely switch from one Anti-TNF drug to another. This is the second time NICE has appraised the sequential effectiveness of multiple biologic therapies following NRAS's successful appeal of negative NICE guidance on switching in 2007... (Source: Arthritis News From Medical News Today)
NICE Consults On Draft Recommendations For Treating Rheumatoid Arthritis After Treatment With A TNF Inhibitor Has Failed
The National Institute for Health and Clinical Excellence (NICE) is currently appraising a number of drugs as possible treatments for rheumatoid arthritis after treatment with a tumour necrosis factor (TNF) inhibitor has failed. This is a part review of NICE technology appraisal guidance 36, and a review of NICE technology appraisal guidance 126 and 141. NICE has put its initial draft guidance on the NICE website, and this is now open for public consultation... (Source: Health News from Medical News Today)
NICE Consults On Draft Recommendations For Treating Rheumatoid Arthritis After Treatment With A TNF Inhibitor Has Failed
The National Institute for Health and Clinical Excellence (NICE) is currently appraising a number of drugs as possible treatments for rheumatoid arthritis after treatment with a tumour necrosis factor (TNF) inhibitor has failed. This is a part review of NICE technology appraisal guidance 36, and a review of NICE technology appraisal guidance 126 and 141... (Source: Arthritis News From Medical News Today)
Arthritis drug 'too costly' for England (but not Scotland)
Thousands of rheumatoid arthritis sufferers in England could be condemned to a lifetime of pain after the drugs rationing body turned down a &#8216;last chance&#8217; treatment available in Scotland. (Source: the Mail online | Health)
A case of emphysematous pyelonephritis in a patient with rheumatoid arthritis taking corticosteroid and low-dose methotrexate
In this report, we describe a case of emphysematous pyelonephritis in a patient with RA associated with AA amyloidosis and steroid-induced diabetes mellitus who was taking corticosteroid and low-dose methotrexate. (Source: APLAR Journal of Rheumatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Combination of etanercept and methotrexate 'effective' in early rheumatoid arthritis
Combination therapy with etanercept and methotrexate is an effective treatment for patients with early active rheumatoid arthritis, new trial data show. (Source: Arthritis Research Campaign)
Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus
Authors: C Rintisch, T Kelkka, U Norin, J C Lorentzen, P Olofsson & R Holmdahl (Source: Genes and Immunity)
Moderators of the Negative Effects of Catastrophizing in Arthritis
Conclusions. Collectively, educational achievement and positive social interactions may protect against some of the deleterious effects of catastrophizing. The design of future interventions to reduce catastrophizing or ameliorate its impact on pain outcomes may benefit from further study of these subgroups of patients. (Source: Pain Medicine)
NICE issues third Appraisal Consultation Document on tocilizumab for rheumatoid arthritis
Source: NICE Area: News NICE has issued its third Appraisal Consultation Document on tocilizumab which contained the following preliminary recommendations: &nbsp; Tocilizumab is not recommended for the treatment of moderate to severe active rheumatoid arthritis in people whose disease has responded inadequately to: &nbsp; .&nbsp;One or more previous DMARDs before, or as an alternative to, treatment with TNF blockers. &nbsp; .&nbsp;One or more previous TNF blocker before, or as an alternative to, treatment with rituximab. &nbsp; .&nbsp;Previous TNF blockers and who are intolerant to, or unsuitable for, treatment with rituximab. &nbsp; The Committee recommends that NICE requests cost-effectiveness analyses from the manufacturer of tocilizumab for the scenarios involving ...
Influence of TNF blockers on cancer incidence in patients with rheumatoid arthritis and prior malignancy
Source: Arthritis Care & Research Area: News No previous published studies have been able to address the question as to whether anti-TNF therapy influences the rate of malignancy in patients with prior malignancy. Using data from the British Society for Rheumatology Biologics Register (BSRBR), researchers conducted this study in an attempt to answer this question. &nbsp; A total of 293 patients with a prior malignancy were identified from over 14,000 patients with rheumatoid arthritis (RA) and the rates of incident malignancy were analysed in 177 anti-TNF treated patients and 117 patients with active RA treated with traditional DMARDs, all with prior malignancy. &nbsp; The rates of incident malignancy were 25.3 events/ 1000 person years in the anti-TNF cohort and 38.3 / 1000 perso...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy.
Authors: Bondeson J The great success of targeted biologic therapy against rheumatoid arthritis (RA) in recent years has meant that much research has been devoted to investigating the pathophysiology of osteoarthritis (OA) in the hope of defining novel therapeutic targets. In contrast to RA, with its pannus and erosions, OA has long been thought of as a degenerative disease of cartilage, with secondary bony damage and osteophytes. But in recent years, the importance of the synovium, and in particular the synovial macrophages, in OA, has been highlighted in both in vitro and in vivo studies. This review will discuss the potential of synovial macrophages and their mediators, in particular the proinflammatory cytokines tumour necrosis factor alpha and interleukin-1, as potential therapeut...
Smoking, Use of Moist Snuff and Risk of Chronic Inflammatory Diseases.
CONCLUSION: Smokeless tobacco does not increase the risk of chronic inflammatory diseases, suggesting that inhaled non-nicotinic components of cigarette smoke are more important than nicotine itself in the aetiology of these diseases. PMID: 20203245 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Continuing Professional Development Is Associated With Increasing Physical Therapists' Roles in Arthritis Management in Canada and the Netherlands.
CONCLUSIONS:/b&gt; This exploratory analysis highlights the association between participation in arthritis-related CPD courses and the roles assumed by physical therapists in OA and RA management. Further research is needed to understand the effects of CPD activities on other areas of physical therapist practice and on patients' outcomes. PMID: 20203095 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Qualitative Research Ethics: Enhancing Evidence-Based Practice in Physical Therapy.
CONCLUSIONS:/b&gt; These findings build on previous research and discussion in physical therapy and other disciplines that urge a flexible approach to qualitative research ethics and recognize that ethics are embedded in an unfolding research process involving the role of the subjective researcher and an active participant. We suggest reflexivity as a way to recognize ethical moments throughout qualitative research and to help build methodological and ethical rigor in research relevant to physical therapist practice. PMID: 20203093 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Effects of a 6-Week, Individualized, Supervised Exercise Program for People With Bleeding Disorders and Hemophilic Arthritis.
CONCLUSIONS:/b&gt; A professionally designed and supervised, individualized exercise program is feasible, safe, and beneficial for people with bleeding disorders, even in the presence of concomitant disease. A longitudinal study with a larger sample size, a blinded examiner, and a control group is needed to confirm the results. PMID: 20203091 [PubMed - as supplied by publisher] (Source: Physical Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
The Relationship Between Mental and Physical Health
People with depression often have worse physical health, as well as worse self-perceived health, than those without depression. Depression and other physical health conditions have separate but additive effects on well-being. For example, the combination of heart disease and depression can cause twice the reduction in social interaction than either condition alone. Patients with both depression and physical health problems are at particular risk: The physical problem can complicate depression&#8217;s assessment and treatment by masking or mimicking its symptoms. It can work the other way as well. People with any chronic physical disease tend to feel more psychological distress than do healthy people. Poor physical health brings an increased risk of depression, as do the social and relati...
Capacity planning in rheumatology day units
A comparison of the administration regimens for two rheumatoid arthritis drugs across three hospital day units has highlighted an opportunity for substantial time savings for healthcare providers and patients. (Source: HSJ)
Tim's Cascade Snacks Recalls 'Hawaiian® Kettle Style Potato Chips - Sweet Maui Onion' and 'Hawaiian- Sweet Maui Onion Rings' Because of Possible Health Risk
Out of regard and concern for our consumers, Tim?s Cascade Snacks of Algona, Washington is recalling ?HAWAIIAN® Kettle Style Potato Chips - SWEET MAUI ONION? AND ?HAWAIIAN - SWEET MAUI ONION RINGS? because they have the potential to be contaminated with Salmonella, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Healthy persons infected with Salmonella often experience fever, diarrhea (which may be bloody), nausea, vomiting and abdominal pain. In rare circumstances, infection with Salmonella can result in the organism getting into the bloodstream and producing more severe illnesses such as arterial infections (i.e., infected aneurysms), endocarditis and arthritis. (Source: Foo...
Rheumatologists Have Plenty Of Choice Among Biologic Agents For RA - Where Will Actemra Find Its Niche?
BioTrends Research Group released topline findings from LaunchTrends®: ACTEMRA, Wave 1, highlighting the market uptake of the product at one month post launch. Actemra (tocilizumab), marketed by Roche-Genentech, is a new IL-6 inhibitor with monthly dosing by IV infusion. The study results are based on an on-line survey completed by 77 rheumatologists in late February... (Source: Arthritis News From Medical News Today)
Rheumatologists Have Plenty Of Choice Among Biologic Agents For RA - Where Will Actemra Find Its Niche?
BioTrends Research Group released topline findings from LaunchTrends®: ACTEMRA, Wave 1, highlighting the market uptake of the product at one month post launch. Actemra (tocilizumab), marketed by Roche-Genentech, is a new IL-6 inhibitor with monthly dosing by IV infusion. The study results are based on an on-line survey completed by 77 rheumatologists in late February... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
RCN joins call for positive action for those with musculoskeletal disorders
The Royal College of Nursing is joining with other members of the Arthritis and Musculoskeletal Alliance (ARMA) to call for positive action to ensure people with musculoskeletal disorders are properly supported to access employment and remain in their jobs. (Source: Royal College of Nursing - UK- National News)
Anti-arthritic Action Mechanisms of Natural Chondroitin Sulfate in Human Articular Chondrocytes and Synovial Fibroblasts.
Authors: Imada K, Oka H, Kawasaki D, Miura N, Sato T, Ito A To clarify the exact anti-arthritic action mechanisms of chondroitin sulfate (CS), we evaluated the effects of CS derived from shark cartilage (CS-SC) composed mainly of chondroitin-6-sulfate and porcine trachea cartilage (CS-PC) composed mostly of chondrotin-4-sulfate on the functions of human articular chondrocytes and synovial fibroblasts. Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts. In addition, CS-SC and CS-PC overcame the IL-1beta-mediated...
Does Vitamin D Deficiency Cause Symptoms?
Title: Does Vitamin D Deficiency Cause Symptoms?Category: Doctor's ViewsCreated: 3/3/2010 1:48:00 PMLast Editorial Review: 3/3/2010 1:48:43 PM (Source: MedicineNet Arthritis General)
More workplace help' needed for people with musculoskeletal disorders
Campaign groups, policymakers and employers have called for people with musculoskeletal disorders (MSDs) to receive more support to help them stay at work. (Source: Arthritis Research Campaign)
Study finds fat types have different effects on bone health
A new study has found that the bone health of obese teenage girls may depend on the type of fat they carry. (Source: Arthritis Research Campaign)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
NICE issues preliminary recommendations (ACD) on drugs for treatment of rheumatoid arthritis after failure of a TNF inhibitor
Source: NICE Area: News NICE has been asked to produce guidance on using adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a TNF inhibitor in the NHS in England and Wales. The Appraisal Committee has issued an Appraisal Consultation Document (ACD), which includes the following preliminary recommendations: &nbsp; 1.1 Rituximab in combination with methotrexate is recommended as an option for the treatment of adults with severe active rheumatoid arthritis: .&nbsp;that has responded inadequately to other disease-modifying anti-rheumatic drugs (DMARDs), including treatment with at least one tumour necrosis factor (TNF) inhibitor, or .&nbsp;who are intolerant of other DMARDs. &nbsp; 1.2 Treatment with rituximab in ...
Arthritis Prevalence Is Higher in U.S. Than in Canada
Arthritis is significantly more prevalent in the United States than in Canada, especially in American women, according to a study published in the March issue of Arthritis Care &amp; Research. Authors of the study postulate increase may be due to higher rates of obesity and physical inactivity. (Source: Modern Medicine)
Autoantibodies in Autoimmune Diseases.
Authors: Eggert M, Zettl UK, Neeck G The occurrence of autoantibodies is a common feature of autoimmune diseases. This review is intended to give an overview of the most important autoantibodies and their role in diagnosis, disease activity and prognosis in rheumatoid arthritis (RA), systemic lupus erythematodes (SLE) and multiple sclerosis (MS). Whereas in RA and SLE these antibodies are meaningful for diagnosis and partially for the prognosis of the disease, the situation is quite different in the case of MS. Up to date, no specific antibody is known to be exclusively present in the serum or cerebrospinal fluid (CSF) of MS-patients compared to the respective fluids of healthy individuals. Nevertheless, there are some antigens that are reported to be bound significantly more often by ...
Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium.
Authors: Hueber AJ, Asquith DL, Miller AM, Reilly J, Kerr S, Leipe J, Melendez AJ, McInnes IB The proinflammatory cytokine IL-17A is considered a crucial player in rheumatoid arthritis (RA) pathogenesis. In experimental models of autoimmune arthritis, it has been suggested that the cellular source of IL-17A is CD4(+) T cells (Th17 cells). However, little is known about the source of IL-17 in human inflamed RA tissue. We explored the cellular sources of IL-17A in human RA synovium. Surprisingly, only a small proportion of IL-17-expressing cells were T cells, and these were CCR6 negative. Unexpectedly, the majority of IL-17A expression colocalized within mast cells. Furthermore, we demonstrated in vitro that mast cells produced RORC-dependent IL-17A upon stimulation with TNF-alpha, IgG c...
Primary Care Doctors Ordering Unnecessary Scans
Title: Primary Care Doctors Ordering Unnecessary ScansCategory: Health NewsCreated: 3/1/2010 4:10:00 PMLast Editorial Review: 3/2/2010 (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Get the very latest Swine Flu news via the MedWorm <b><a href="http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29&t=Swine+Flu&f=infectiousdiseases&r=Any&o=d" target ="_self">Swine Flu RSS news feed</a></b> - updated hourly from thousands of authoritative health and news sources.</p></div>
Tuesday 2 March
Back-pain help for workers: Employers need to do more to help people with back and joint pain stay in work, according to experts. The Arthritis and Musculoskeletal Alliance called for a range of measures and rights to tackle the issue, which costs society an estimated £7bn a year. The alliance, an umbrella group representing 34 charities and health bodies including the National Osteoporosis Society, Royal College of Nursing and Chartered Society of Physiotherapy, believes more should be done to help those already suffering ill-health. (Source: Royal College of Nursing News Alert)
The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study
Conclusions: Biologic therapy retards RA progression, but its effect is far less than is seen in clinical trials. In the community, cost-effectiveness is substantially less than that estimated from clinical trial data. The study results represent the incremental benefit of adding biologic therapy to optimum non-biologic therapy. (Source: Arthritis Research and Therapy)
Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages
Conclusions: The application of more physiologic oxygen percentage during specific phases of differentiation culture enhanced the biosynthetic activity and reduced the activity of catabolic enzymes implicated in cartilage breakdown. Modulation of the oxygen percentage during HAC culture may be used to study pathophysiological events occurring in osteoarthritis and to enhance properties of in vitro engineered cartilaginous tissues. (Source: Arthritis Research and Therapy)
Distribution of candidate genes for experimentally induced arthritis in rats
Conclusions: From the genome wide CGC search, we conclude that candidate genes for arthritis in rat are randomly distributed between QTL and non-QTL regions. We do however find certain pairs of QTLs that share a large number of functionally connected candidate genes, suggesting that these QTLs contain a number of genes involved in similar functions contributing to the arthritis phenotype. (Source: BMC Genomics - Latest articles)

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