Arthritis

treatments under study and how x-rays are inadequate for diagnosis- Rheumatoid - New treatments, associated complications, and important preventative strategies for this form of that affects 1% of all Americans- Systemic Lupus Erythematosus - Medications, pregnancy, birth control pills, and controlling heart disease and stroke risks"Medical research, such as that I have reviewed, is essential for improving the health of those suffering from arthritis. has dramatic effects on the function and well-being of hundreds of millions of people worldwide," notes Dr.

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Interposition Arthroplasty Options for Carpometacarpal Arthritis of the Thumb
Carpometacarpal (CMC) arthritis of the thumb affects half of postmenopausal women and up to 25% of elderly men. This disease can cause significant disability in affected patients often necessitating surgical intervention. Various surgical options have been used to treat refractory CMC arthritis. Any successful surgical intervention must address three goals: removal of diseased joint surfaces, reconstruction of ligamentous stabilizers, and preservation of the joint space. In this article we will discuss various interposition arthroplasty options for CMC arthritis of the thumb. (Source: Hand Clinics)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Implant Arthroplasty of the Carpometacarpal Joint of the Thumb
Resection arthroplasty with or without ligament reconstruction for thumb trapeziometacarpal arthritis can be complicated by thumb shortening and pinch-strength weakness. Implant arthroplasties have been developed to limit loss of thumb length, improve strength, and limit postoperative convalescence. The ideal thumb carpometacarpal implant should be strong and stable, provide full range of motion, and prevent loosening. Unfortunately, no current prosthesis accomplishes all of these goals. Until the ideal implant is developed, clinical acumen must be used to determine appropriate patients and implants. (Source: Hand Clinics)
ITGAM Arg77His Is Associated with Disease Susceptibility, Arthritis, and Renal Symptoms in Systemic Lupus Erythematosus Patients from a Sample of the Polish Population
DNA and Cell Biology , Vol. 0, No. 0. (Source: DNA and Cell Biology)
The Effects of a Physical Activity Program on Sleep-and Health-Related Quality of Life in Older Persons With Arthritis
Few studies have examined the effects of physical activity on sleep in older adults. The purpose of this study was to examine the short- and long-term effects of an 8-week, low-to-moderate-intensity physical activity program on improvements in sleep and health-related quality of life (HRQOL) in a sample of community-based older adults with arthritis (N = 346). Participants were randomly assigned to an intervention group or control group that received the intervention on a delayed basis. Sleep and HROQL were assessed with self-report instruments at baseline and 8 weeks using intention-to-treat (ITT) and as-treated (AT) analyses. The intervention group was also assessed at 3 and 6 months. At 8 weeks, the intervention group reported fewer days waking up tired (ITT and AT results) and fewer da...
Leap forward in efforts to develop treatments for Huntington's disease
Research reveals that an enzyme linked with multiple disorders -- including stroke, cancer and rheumatoid arthritis -- is also involved in the generation of toxic protein fragments in Huntington's disease. (Source: ScienceDaily Headlines)
Could Drinking Help Thwart Rheumatoid Arthritis?
Early study suggests it might, but that's no reason to imbibe heavily, experts say (Source: The Doctors Lounge - Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Alcohol Use Lowers RA Risk (CME/CE)
(MedPage Today) -- Alcohol consumption was associated with a significant and dose-related reduction in susceptibility to rheumatoid arthritis, a retrospective British study found. (Source: MedPage Today Geriatrics)
Alcohol can lessen arthritis symptoms, study claims
Results show that teetotallers are four times more likely to develop rheumatoid arthritis than those who drink alcohol on more than ten days a month. (Source: the Mail online | Health)
New Study Reveals UK Patients Are Less Likely To Receive Innovative Medicines
One of the most comprehensive reports comparing the use of medicines in the UK with that in other countries has been published by the Department of Health. The report shows that the UK still lags behind comparable countries in Europe and elsewhere on its use of newer cancer treatments and medicines for chronic diseases such as rheumatoid arthritis, multiple sclerosis and dementia... (Source: Health News from Medical News Today)
Rheumatoid Arthritis Severity Reduced By Alcohol
Drinking alcohol may reduce the severity of rheumatoid arthritis according to new research justg published. It is the first time that this effect has been shown in humans. The study also finds that alcohol consumption reduces the risk of developing the disease, confirming the results of previous studies. The study which is published online in the journal Rheumatology, looked at 873 patients with rheumatoid arthritis and compared them with 1004 people without RA (the control group)... (Source: Health News from Medical News Today)
Alcohol and arthritis link examined
Conclusion This study appears to show an association between a higher frequency of alcohol consumption and both reduced risk of developing rheumatoid arthritis and decreased severity of the disease. However, there are limitations to this study (many of which the researchers highlight), which mean that the conclusions should be interpreted cautiously: This study required the patients to recall their own alcohol consumption, meaning the patients and controls may have over- or under-estimated the amount of alcohol they had consumed. The study asked the participants about the frequency of their drinking rather than about how much they typically drank. As we cannot tell what quantities of alcohol were consumed, it is therefore possible that some individuals who drank less frequently might...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Alcohol reduces the severity of rheumatoid arthritis, study finds
Drinking alcohol may reduce the severity of rheumatoid arthritis, according to new research. It is the first time that this effect has been shown in humans. The study also finds that alcohol consumption reduces the risk of developing the disease, confirming the results of previous studies. (Source: ScienceDaily Headlines)
Rheumatologic Manifestations of Sarcoidosis
We present two cases of sarcoidosis with rheumatologic manifestations. Our intent is to encourage a multidisciplinary, translational approach to meet the challenges and difficulties in understanding and treating sarcoidosis.[...]© Thieme Medical PublishersGet connected:Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Managing Gout in the Primary Care Setting: What You and Your Patients Need to Know
Abstract: The US prevalence of gout, a rapidly progressive inflammatory arthritic condition linked to serum uric acid levels, has grown in recent years, in part due to the increasing prevalence and incidence of predisposing factors in the population, such as metabolic syndrome, obesity, and the use of diuretics. Left untreated, gout can be debilitating and cause deformity. Although a definitive diagnosis requires joint aspiration, only ?11% of patients with suspected gout undergo this procedure, and a presumptive diagnosis based on patient medical history and presentation with characteristic symptoms and comorbidities is a reasonable guidelines-based approach that has utility in the primary care setting, where approximately 70% of all cases and nearly 3,000,000 visits occur. The therapeu...
Study: Alcohol Helps Rheumatoid Arthritis Symptoms
Rheumatoid arthritis patients who drink alcohol tend to have less severe symptoms than those who don?t, a new study finds. (Source: WebMD Health)
Septic arthritis: Stopping the pain, damage to your joint
Septic arthritis &mdash; Comprehensive overview covers symptoms and treatment of joint infections caused by bacteria. (Source: MayoClinic.com Full Feed)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Subchondral Bone Changes Contribute to Cartilage Damage and Loss
This study looks at the issue. Arthritis & Rheumatism Research News Alerts (Source: Medscape Rheumatology Headlines)
Leap forward in efforts to develop treatments for Huntington's disease
(Buck Institute for Age Research) Research reveals that an enzyme linked with multiple disorders -- including stroke, cancer and rheumatoid arthritis -- is also involved in the generation of toxic protein fragments in Huntington's disease. (Source: EurekAlert! - Medicine and Health)
Alcohol can 'lessen' arthritis
Drinking alcohol can reduce the severity of rheumatoid arthritis symptoms, a study has found (Source: BBC News | Health | UK Edition)
A regular tipple may ease rheumatoid arthritis symptoms
DRINKING alcohol reduces the severity of the symptoms of rheumatoid arthritis, a pioneering new study has revealed. (Source: Scotsman.com News - Health)
Alcohol may fight rheumatoid arthritis
Moderate drinking has been linked to a variety of health benefits, including a reduced risk of heart disease, stroke, and diabetes. According to a new study, drinking alcohol may also ease the pain of -- and lower the risk of developing -- rheumatoid arthritis, a potentially crippling autoimmune disorder. (Source: CNN.com - Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Metabolic panniculitis: alpha-1 antitrypsin deficiency panniculitis and pancreatic panniculitis
Panniculitis can be the initial presentation of both alpha-1 antitrypsin deficiency and pancreatic disease. They can both present with abscess-like draining nodules, but may present like other forms of panniculitis with erythematous nodules. It is important to consider these in the differential diagnosis of patients presenting with panniculitis. Alpha-1 antitrypsin deficiency is a relatively common disorder mainly affecting the lungs and liver. It frequently goes undiagnosed, yet critical interventions can be made to minimize disease progression. Panniculitis associated with alpha-1 antitrypsin deficiency can be difficult to treat. Pancreatic panniculitis occurs in less than 3% of patients with underlying pancreatic disease and is often associated with arthritis. Diagnosis and treatment of...
Tocilizumab for rheumatoid arthritis
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Tocilizumab, a new biologic that inhibits interleukin-6, is approved for treatment of rheumatoid arthritis (RA) in Europe, Japan and the US. &nbsp; Objectives To assess the efficacy and safety of tocilizumab in patients with RA using the data from published randomized or quasi-randomized controlled trials (RCTs). &nbsp; &nbsp; Search strategy We performed a search of the following databases: the Cochrane Central Register of Controlled Trials (CENTRAL) up to issue 3, 2009; OVID MEDLINE(1966 to 1 October 2009); CINAHL(1982 to 2009); EMBASE (1980 to week 39, 2009); Science Citation Index (Web of Science) (1945 to 2009) and Current Controlled Trials. &nbsp; Selection criteria Tocilizumab al...
CADTH Review: Biological agents for rheumatoid arthritis
Source: CADTH Area: News The Canadian Agency for Drugs and Technologies in Health (CADTH) has conducted a therapeutic review to evaluate the comparative effectiveness, harms, and cost-effectiveness of biologic response modifier agents for adults with rheumatoid arthritis. (Source: NeLM - News)
Drinking Alcohol May Thwart Rheumatoid Arthritis
Drinking alcohol appears to be protective against the development of rheumatoid arthritis and to be associated with less severe symptoms in those who have the condition, according to research published online July 28 in Rheumatology. (Source: Modern Medicine)
Osteoarthritis and a high-fat diet: the full 'osteoarthritis syndrome' in a small animal model
Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue shows that a high-fat diet leads to obesity and OA in part of the studied animals and that this is related to alterations in locomotor function. Furthermore, a high-fat diet leads to pain sensitization and depression/anxiety-like behavior unrelated to structural OA changes in the knee. Their findings demonstrate that the majority of features of the human "OA syndrome" can be reproduced in a small animal model. (Source: Arthritis Research and Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Drinking alcohol can reduce the severity of rheumatoid arthritis
Non-drinkers are four times more likely to develop RA than regular drinkersRelated items from OnMedicaHyaluronate gets thumbs up for chronic shoulder painAdult pain linked to childhood bad behaviourHeavy babies risk rheumatoid arthritis in adulthoodRegular tipple may halve risk of rheumatoid arthritisRCN will appeal if rheumatoid arthritis drug is restricted (Source: OnMedica Latest News)
Ross Operation in a Patient With Juvenile Rheumatoid Arthritis [CASE REPORTS]
A 32-year-old woman with juvenile rheumatoid arthritis underwent a redo aortic valve replacement 7 years after a Ross procedure for severe aortic valve regurgitation. Interestingly, the cause of autograft failure was not related to the rheumatoid inflammation process. (Source: The Annals of Thoracic Surgery)
Clinical Trials Update: July 27, 2010
Iron Deficiency Anemia Hepatitis C Rheumatoid Arthritis (Source: The Doctors Lounge - Health News)
Rheumatoid Arthritis of the Hand: Monitoring with a Simplified MR Imaging Scoring Method--Preliminary Assessment [MUSCULOSKELETAL IMAGING]
Although Simplified Rheumatoid Arthritis Magnetic Resonance Imaging Score (SAMIS) must be further validated in more patients and longitudinal studies, our results indicated that damage to joints in patients with rheumatoid arthritis could be reliably evaluated with SAMIS; SAMIS was closely correlated with and as reproducible as Rheumatoid Arthritis Magnetic Resonance Imaging Score, while being less time-consuming. (Source: Continuous Publishing articles)
Safety of rituximab in rheumatoid arthritis.
Authors: Covelli M, Sarzi-Puttini P, Atzeni F, Macchioni P Rheumatoid arthritis (RA) is a chronic disease that requires a long-term administration of immunomodulatory drugs with a greater risk of side effects like malignancies, serious infections and cardiovascular diseases. Furthermore, patients with RA are more prone than general population to these manifestations. Safety of rituximab has been evaluated in the short-term (6 months) and in the medium-term (up to 10 years) in patients who had been previously treated with antagonists of tumor necrosis factor (a-TNF) and/or with methotrexate (MTX) and in patients who were not. Data obtained from clinical trials demonstrated that rituximab is well tolerated either after a single course or after multiple courses. The overall rate of advers...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Horizon Pharma, Inc. Announces Results Of Phase 3 Study Of LODOTRA® Demonstrate 12-Month Sustained Efficacy And Safety In Rheumatoid Arthritis
Horizon Pharma, Inc. announced the results from the extended open label portion of The Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) Phase 3 European registration study of LODOTRA®, a programmed release formulation of low-dose prednisone, which showed sustained improvement in reducing the duration of morning stiffness in patients with Rheumatoid Arthritis (RA) over a 12 month period... (Source: Health News from Medical News Today)
Pleurisy (Pleuritis)
Title: Pleurisy (Pleuritis)Category: Diseases and ConditionsCreated: 2/20/2002 11:32:00 AMLast Editorial Review: 7/27/2010 (Source: MedicineNet Arthritis General)
Study Explores Links Between Obesity and Chronic Pain
Title: Study Explores Links Between Obesity and Chronic PainCategory: Health NewsCreated: 7/26/2010 12:10:00 PMLast Editorial Review: 7/27/2010 (Source: MedicineNet Arthritis General)
Adherence to recommended exercise improves physical function, reduces pain for OA patients
(Wiley-Blackwell) Patients with osteoarthritis of the knee or hip who adhere to the recommended home physical therapy exercises and physically active lifestyle experience more improvement in pain, physical function, and self-perceived effect according to a study from researchers in the Netherlands. Details of the study are available online and will publish in the August print issue of Arthritis Care & Research, a journal of the American College of Rheumatology. (Source: EurekAlert! - Medicine and Health)
'I start my day by thinking about what we're going to have for dinner'&#x2013; a qualitative study on approaches to food-related activities among elderly men with somatic diseases
Scand J Caring Sci; 2010'I start my day by thinking about what we're going to have for dinner'[ndash] a qualitative study on approaches to food-related activities among elderly men with somatic diseases The aim of this study was to address the question of how older men with somatic diseases living in their own home approach the question of food-related activities (FRA). Further, any adaptations of these activities necessitated by effects of diseases and of altered life circumstances were explored. Interviews were conducted with a purposeful sample of 18 co-living and single-living men, 64[ndash]84 years old. They were diagnosed with Parkinson's disease, rheumatoid arthritis or stroke. In the analysis, a thematic framework was used. The findings revealed three food-related approaches, namel...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
No evidence of association between anti-TNF treatment and mortality in patients with rheumatoid arthritis
Source: Arthritis and Rheumatism Area: News According to research published early online in Arthritis and Rheumatism, compared to patients treated with standard DMARDs, the addition of anti-TNF therapy was not associated with an increase in mortality. &nbsp; Researchers prospectively followed 12,672 patients starting anti-TNF therapy and 3522 biologic-naive patients receiving DMARDs until 31 July 2008 or death, whichever was sooner. Patients for this study were participants in the British Society for Rheumatology Biologics Register (BSRBR), which recruits patients with a physician diagnosis of RA starting one of the three available anti-TNF therapies etanercept, infliximab and adalimumab. The primary aim of the BSRBR is to assess the long-term safety of these agents in patients with R...
Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity
Abstract&nbsp;&nbsp;Soluble interleukin-6 receptor ? subunit (sIL-6R) is primarily generated by shedding of the membrane-bound form. This process is influenced by the single nucleotide polymorphism rs8192284 (A&nbsp;&gt;&nbsp;C) resulting in an aspartic acid to alanine substitution (D358A) at the proteolytic cleavage site. The aim of this study was to determine whether plasma levels of sIL6R are influenced by the rs8192284 polymorphism in patients with rheumatoid arthritis and to assess the association between plasma sIL-6R levels and disease activity as reflected by anti-CCP status. Thirty-nine patients were randomly selected from a cohort of patients with RA of Spanish descent. Plasma sIL-6R concentrations were measured using sandwich ELISA. Genotyping of the rs8192284 (A&nbsp;&gt;...
Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study
Abstract&nbsp;&nbsp;Immune system and bone are interacting in a complex way. Rheumatoid arthritis is characterized not only by joint destruction, but also by development of systemic osteopenia and osteoporosis. The CD20-depleting antibody Rituximab (Rtx) is a novel therapeutic option able significantly to slow the destructive joint process of rheumatoid arthritis. However, there are little data whether Rtx influences systemic bone remodeling. In the present prospective study, we evaluated the influence of Rtx on markers of bone metabolism with a follow-up of 3?15&nbsp;months after Rtx therapy (2 dose of each 1,000&nbsp;mg) in 13 patients with rheumatoid arthritis. There was no significant change of the bone formation markers bone alkaline phosphatase and c-terminal propeptide of co...
Risk Factors for Hip Problems Among Assembly Plant Workers
Conclusions Hip disorders are associated with a history of biomechanical trauma to the hip but also from gait abnormalities such as pes planus. Content Type Journal ArticleDOI 10.1007/s10926-010-9259-zAuthors Robert A. Werner, University of Michigan Health System Department of Physical Medicine and Rehabilitation Ann Arbor MI USANancy Gell, University of Michigan Health System Department of Physical Medicine and Rehabilitation Ann Arbor MI USAAnne Hartigan, University of Michigan Health System Department of Physical Medicine and Rehabilitation Ann Arbor MI USANeal Wiggermann, University of Michigan Center for Ergonomics, Industrial and Operations Engineering Ann Arbor MI USAMonroe Keyserling, University of Michigan Center for Ergonomics, Industrial and Operations Engineering Ann Ar...
San Antonio researcher wins $450,000 grant to advance arthritis treatments
Southwest Foundation for Biomedical Research scientist Lorena M. Havill has been awarded major financial support for her research into the genetic causes of osteoarthritis. (Source: bizjournals.com Health Care:Health Insurance headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
San Antonio researcher wins $450,000 grant to advance arthritis treatments
Southwest Foundation for Biomedical Research scientist Lorena M. Havill has been awarded major financial support for her research into the genetic causes of osteoarthritis. (Source: bizjournals.com Health Care:Biotechnology headlines)
New Drugs for Rheumatoid Arthritis: What's in the Pipeline
The latest on research and development about oral biologics to treat rheumatoid arthritis. (Source: WebMD Health)
Treating Your RA: Is It Time for a Biologic?
Learn about your options for rheumatoid arthritis treatment, including what your doctor looks for, and the benefits and alternatives to a biologic. (Source: WebMD Health)
Obesity at Age 18 Years Linked to Greater Risk for Psoriatic Arthritis
In a case series, adiposity was associated with higher levels of inflammatory cytokines involved in psoriasis; early management of obesity may decrease the risk for psoriatic arthritis. Medscape Medical News (Source: Medscape Today Headlines)
Dosing patterns and costs of tumor necrosis factor inhibitor use for rheumatoid arthritis.
Conclusion Dose increases with TNF inhibitors commonly occurred in RA patients in the clinical setting and were associated with greater costs of anti-TNF therapy. PMID: 20651319 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
'Miracle' tea is the choice of celebrities but fears of side-effects linger
It's been hailed as the miracle tea that can do everything, promising to fight cancer, ward off infections, treat arthritis and even help you lose weight. (Source: the Mail online | Health)
Docs May Be Slow to Diagnose Arthritis of Back, Study Suggests
Title: Docs May Be Slow to Diagnose Arthritis of Back, Study SuggestsCategory: Health NewsCreated: 7/23/2010 4:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Chronic Pain General)
Docs May Be Slow to Diagnose Arthritis of Back, Study Suggests
Title: Docs May Be Slow to Diagnose Arthritis of Back, Study SuggestsCategory: Health NewsCreated: 7/23/2010 4:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Senior Health General)
New Pain Drug May Be Alternative to Oxycodone
Title: New Pain Drug May Be Alternative to OxycodoneCategory: Health NewsCreated: 7/26/2010 10:11:00 AMLast Editorial Review: 7/26/2010 10:11:03 AM (Source: MedicineNet Arthritis General)
Irritable Bowel Syndrome in the Brain
Title: Irritable Bowel Syndrome in the BrainCategory: Health NewsCreated: 7/26/2010 9:34:00 AMLast Editorial Review: 7/26/2010 9:34:40 AM (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Docs May Be Slow to Diagnose Arthritis of Back, Study Suggests
Title: Docs May Be Slow to Diagnose Arthritis of Back, Study SuggestsCategory: Health NewsCreated: 7/23/2010 4:10:00 PMLast Editorial Review: 7/26/2010 (Source: MedicineNet Arthritis General)
NETAG appraisal and recommendations on tocilizumab (RoActemra®) for juvenile idiopathic arthritis
Source: North East Treatment Advisory Group Area: Evidence > Drug Specific Reviews The North East Treatment Advisory Group (NETAG) has published an appraisal report and associated recommendations regarding the use of tocilizumab (RoActemra®) for juvenile idiopathic arthritis. &nbsp; The group's recommendations are as follows: &nbsp; .&nbsp;Tocilizumab is recommended within NHS North East as an alternative to anakinra for the treatment of systemic-onset juvenile idiopathic arthritis in those who have already received treatment with etanercept and adalimumab.&nbsp; .&nbsp;Tocilizumab is not recommended within NHS North East for the treatment of polyarticular juvenile idiopathic arthritis.&nbsp; The decision summary notes that individual patients in exceptional circumstances may b...
Back Pain Diagnostic Blocks Delay Pain Relief, Add Cost
Performing one or more temporary diagnostic nerve blocks to establish arthritis as the cause of back pain before treatment with radiofrequency denervation results in unnecessary tests, delayed pain relief, and added cost, according to a study in the August issue of Anesthesiology. (Source: Modern Medicine)
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
IntroductionSystemic lupus erythematosus (SLE) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and clinical manifestations. SLE-associated autoantibodies and high serum interferon alpha (IFN-alpha) are important heritable phenotypes in SLE which are correlated with each other, and play a role in disease pathogenesis. These two heritable risk factors are shared between ancestral backgrounds. The aim of the study was to detect genetic factors associated with autoantibody profiles and serum IFN-alpha in SLE. Methods: We undertook a case-case genome-wide association study of SLE patients stratified by ancestry and extremes of phenotype in serology and serum IFN-alpha. Single nucleotide polymorphisms (SNPs) in seven loci were selected f...
Calgary man receives historic live cartilage transplant
A Calgary man has made history after receiving the first transplant of live cartilage into his shoulder. Researchers hope the technique will one day lead to a treatment for arthritis. (Source: CTV Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
'Miracle' tea is the choice of celebrities but fears on side effects linger
It's been hailed as the miracle tea that can do everything, promising to fight cancer, ward off infections, treat arthritis and even help you lose weight. (Source: the Mail online | Health)
Price regulation, new entry, and information shock on pharmaceutical market in Taiwan: a nationwide data-based study from 2001 to 2004
Conclusions: Our empirical study found that new drug entry was the main driving force behind escalating drug spending, especially by altering the market share. (Source: BMC Health Services Research)
Cold and heat pattern of rheumatoid arthritis in traditional Chinese medicine: distinct molecular signatures indentified by microarray expression profiles in CD4-positive T cell
Abstract&nbsp;&nbsp;The research is aimed to explore the distinct molecular signatures in discriminating the rheumatoid arthritis patients with traditional Chinese medicine (TCM) cold pattern and heat pattern. Twenty patients with typical TCM cold pattern and heat pattern were included. Microarray technology was used to reveal gene expression profiles in CD4+ T cells. The signal intensity of each expressed gene was globally normalized using the R statistics program. The ratio of cold pattern to heat pattern in patients with RA at more or less than 1:2 was taken as the differential gene expression criteria. Protein?protein interaction information for these genes from databases was searched, and the highly connected regions were detected by IPCA algorithm. The significant pathways we...
Serum cystatin C level in patients with rheumatoid arthritis after single infusion of infliximab
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00296-010-1572-5Authors M. Kopec-Medrek, Medical University of Silesia Department of Internal Medicine and Rheumatology Katowice PolandM. Widuchowska, Medical University of Silesia Department of Internal Medicine and Rheumatology Katowice PolandA. Kotulska, Medical University of Silesia Department of Internal Medicine and Rheumatology Katowice PolandE. Zycinska-D?bska, Medical University of Silesia Department of Internal Medicine and Rheumatology Katowice PolandE. J. Kucharz, Medical University of Silesia Department of Internal Medicine and Rheumatology Katowice Poland Journal Rheumatology InternationalOnline ISSN 1437-160XPrint ISSN 0172-8172 (Source: Rheumatology International)
Influence of sex on surgical time in primary total knee arthroplasty.
Conclusion: Total knee arthroplasty in men requires more time than in women because of the complexity of exposure and to achieve the desired alignment of the components. Our data may allow a better resolution of surgery time planning, which could lead to better use of health system resources. PMID: 20646400 [PubMed - in process] (Source: Canadian Journal of Surgery)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Possible Protective Role of Chloramphenicol in TSST-1 and Coagulase-Positive Staphylococcus aureus-Induced Septic Arthritis with Altered Levels of Inflammatory Mediators
Abstract&nbsp;&nbsp;Chloramphenicol is mostly used against coagulase-negative Staphylococcus aureus, and its protective role against coagulase-positive S. aureus is not well studied. In our study, arthritis was induced in mice by S. aureus (Apollo Gleneagles 33 (AG-33) or American Type Culture Collection 25923 (ATCC-25923)) infection. Chloramphenicol was administered after 2&nbsp;h of infection. Mice were killed at 1, 3, 5&nbsp;days post-infection. Mice inoculated with pathogenic Staphylococci (AG-33) expressing coagulase and Toxic shock syndrome toxin-1 (TSST-1), displayed severe arthritis with enhanced bacterial burden in the spleen, cytokine production in serum and synovial tissue, neutrophil recruitment, and cyclooxegenase-2 expression in synovial tissue compared with ATCC-25923-in...
Assessment of cardiac and pulmonary function in children with juvenile idiopathic arthritis
In this study, children with JIA had higher systolic and diastolic blood pressures, resting heart rate, left ventricle systolic size and volume (4.35&nbsp;±&nbsp;0.68 vs. 3.92&nbsp;±&nbsp;0.28, P value&nbsp;=&nbsp;0.02). On Doppler and tissue Doppler analysis, the JIA group had lower peak early filling velocity (E, m/s), higher peak atrial filling velocity (A, m/s) and prolonged diastolic E and A waves deceleration times and isovolumic relaxation time (IRT) compared to control. Regarding pulmonary function tests, children with JIA showed significant decrease in FVC, PEF, Pimax, Pemax and DLCO compared to normal controls. This decrease was not related to age, height or weight of these patients. There was significant inverse correlation between lung function parameters and the rheuma...
Immune complex reaction after successful treatment of meningococcal disease: an excellent response to IVIG
We report excellent response to intravenous immunoglobulin in a child with immune complex reaction following meningococcal sepsis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00296-010-1555-6Authors Rashna Dass, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences Department of Pediatric Disciplines Room no. 218, PO: Mawdiangdiang Shillong Meghalaya 793018 IndiaHimesh Barman, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences Department of Pediatric Disciplines Room no. 218, PO: Mawdiangdiang Shillong Meghalaya 793018 IndiaSaurabh Gohain Duwarah, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences Department of Pediatric Disciplines Room no. 218, PO: Mawdiangdiang Shillong Meghalaya 79301...
IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis
In conclusion, IL-6 inhibition preferentially suppresses the induction of Th17 cells and does not seem to impact on cytokine production of already differentiated Th17 cells. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00296-010-1552-9Authors Hiroto Yoshida, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd. Product Research Department 1-135, Komakado Gotemba, Shizuoka 412-8513 JapanMisato Hashizume, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd. Product Research Department 1-135, Komakado Gotemba, Shizuoka 412-8513 JapanMasahiko Mihara, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd. Product Research Department 1-135, Komakado Gotemba, Shizuoka 412-8513 Japan Journal Rheumatology International...
Diagnostic "Guidelines" A Barrier To Prompt Relief For Some Back Pain
Slavishly following long-held guidelines for diagnosing the cause of arthritis-related back pain is resulting in excessive tests, delays in pain relief and wasteful spending of as much as $10,000 per patient, new Johns Hopkins-led research suggests. Arthritis is a common cause of back pain, though difficult to precisely diagnose, experts say, because of the poor correlation between a finding of arthritis on an X-ray or MRI and the degree of a patient's back pain... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
The changing face of rheumatoid arthritis: sustained remission for all?
Nature Reviews Immunology 10, 605 (2010). doi:10.1038/nri2804 Author: John D. Isaacs Earlier diagnosis and treatment, plus biological therapies, have transformed the outlook for many patients with rheumatoid arthritis. In the future, new biomarkers for diagnosis, prognosis and therapeutic response will further improve outcomes. Additionally, preclinical diagnosis and tolerogenic therapies could provide sustained remission for some individuals, (Source: Nature Reviews Immunology)
Swiss Consensus Statement: Recommendations for optimising re-treatment with MabThera(R) (rituximab) in rheumatoid arthritis.
Authors: Dudler J, Finckh A, Kyburz D, Möller B, Schmiedel U, Villiger P, Walker U Rituximab is an effective treatment of rheumatoid arthritis (RA), which has been approved for the treatment of moderate to severe disease in patients with an inadequate response to anti-TNF therapies. Rituximab differs from other available biological agents for RA by way of its unique mode of action and unrivalled long dosing interval. The efficacy of rituximab subsides progressively over time and re-therapy is generally required to maintain long term disease control. The timing of re-treatment is currently not well established and varies widely in clinical practice. The present document is a concise recommendation regarding re-treatment with rituximab, based on validated outcomes such as the DAS28 an...
Ultrasonography in early assessment of elderly patients with polymyalgic symptoms: a role in predicting diagnostic outcome?
Conclusions: US and PDUS can be useful in distinguishing, at onset of disease, pure PMR from other diseases mimicking this condition. PMID: 20653466 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Docs May Be Slow to Diagnose Arthritis of Back, Study Suggests
As first step, radiofrequency denervation would slash costs, researchers say (Source: The Doctors Lounge - Health News)
Doubt cast on common back pain management
NEW YORK (Reuters Health) - Many people with arthritis-related back pain might be prevented from getting long-lasting pain relief under the current management guidelines, US researchers said Friday. (Source: Reuters: Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Doubt Cast on Common Back Pain Management
Many people with arthritis-related back pain might be prevented from getting long-lasting pain relief under the current management guidelines, US researchers said Friday.Source: Reuters Health Related MedlinePlus Pages: Arthritis, Back Pain (Source: MedlinePlus Health News)
[A cutaneous infection by Mycobacterium chelonae in a patient with rheumatoid arthritis]
Authors: Ferreira O, Duarte AF, Baudrier T, Mota A, Simões JS, Azevedo F There are no pathognomonic findings for cutaneous infection caused by Mycobacterium chelonae. The type and duration of therapy varies considerably among reports and no single antibiotic is considered the treatment of choice. A 61-year-old patient, suffering from rheumatoid arthritis (treated with metotrexate and salazopyrine), presented with violaceous nodules of the right leg that had been evolving for 6 months. She was underwent several skin biopsies. Tissue culture of the last showed an atypical mycobacteria, identified as M. chelonae. Despite improvement after a two-week course of treatment with clarithromycin, a switch to ciprofloxacin was made because of gastrointestinal intolerance. After 3 months, only ...
Study: No nerve blocks, just RF to treat arthritic back pain
Relying on nerve blocks to diagnose arthritis-related back pain prior to treatment may result in excessive tests, delay pain relief and increase costs, according to a study published in the August edition of Anesthesiology. (Source: Health Imaging News)
Study: No nerve blocks, just RF to treat arthritic back pain
Relying on nerve blocks to diagnose arthritis-related back pain prior to treatment may result in excessive tests, delay pain relief and increase costs, according to a study published in the August edition of Anesthesiology. (Source: Health Imaging News)
Study: No nerve blocks, just RF to treat arthritic back pain
Relying on nerve blocks to diagnose arthritis-related back pain prior to treatment may result in excessive tests, delay pain relief and increase costs, according to a study published in the August edition of Anesthesiology. (Source: Health Imaging News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Study: No nerve blocks, just RF to treat arthritic back pain
Relying on nerve blocks to diagnose arthritis-related back pain prior to treatment may result in excessive tests, delay pain relief and increase costs, according to a study published in the August edition of Anesthesiology. (Source: Health Imaging News)
Horizon Pharma, Inc. Announces Results of Phase 3 Study of Lodotra Demonstrate 12-Month Sustained Efficacy and Safety in Rheumatoid Arthritis
- Results published in July Issue of Annals of Rheumatic Diseases - NORTHBROOK, Ill., July 23 /PRNewswire/ -- Horizon Pharma, Inc. announced today the results from the extended open label portion of The Circadian Administration of Prednisone in... (Source: Drugs.com - Clinical Trials)
Cat's Claw
This fact sheet provides basic information about the herb cats claw&#8212;common names, uses, potential side effects, and resources for more information. Cats claw grows wild in many countries of Central and South America, especially in the Amazon rainforest. The use of this woody vine dates back to the Inca civilization.What Cat's Claw Is Used ForCat's claw has been used for centuries in South America to prevent and treat disease.It has been used for a variety of health conditions, including viral infections (such as herpes and HIV), Alzheimer's disease, cancer, and arthritis.Cat's claw has been used to support the immune system and promote kidney health, as well as to prevent and abort pregnancy. (Source: NCCAM Featured Content)
Inflammatory Arthritis Patients Lacking in Preventive Care (CME/CE)
Older patients with inflammatory arthritis are not receiving the full range of age-related preventive care they need, despite their being at increased risk for cardiovascular events, infection, and osteoporosis, a new study found. (Source: MedPage Today State Required CME)
Horizon Pharma, Inc. Announces Results of Phase 3 Study of LODOTRA(R) Demonstrate 12-Month Sustained Efficacy and Safety in Rheumatoid Arthritis
Results published in July Issue of Annals of Rheumatic Diseases NORTHBROOK, Ill., July 23 (HSMN NewsFeed) -- Horizon Pharma, Inc. announced today the results from the extended open label portion of The Circadian Administration of Prednisone in Rheumat... BiopharmaceuticalsHorizon Pharma, LODOTRA, Rheumatoid Arthritis (Source: HSMN NewsFeed)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway [Gene Regulation]
Recent studies suggest that active resolution of the inflammatory response in animal models of arthritis may involve leukotriene B4 (LTB4)-dependent stimulation of "intermediate" prostaglandin production, which in turn favors the synthesis of "downstream" anti-inflammatory and pro-resolving lipoxins, resolvins, and protectins. We explored a putative mechanism involving LTB4-dependent control of cyclooxygenase-2 (COX-2) expression, the rate-limiting step in inflammatory prostaglandin biosynthesis. Indeed, LTB4 potently up-regulated/stabilized interleukin-1&beta;-induced COX-2 mRNA and protein expression under conditions of COX-2 inhibitor-dependent blockade of PGE2 release in human synovial fibroblasts (EC50 = 16.5 &plusmn; 1.7 nm for mRNA; 19 &plusmn; 2.4 nm for protein, n = 4). The latter...
Horizon Pharma, Inc. Announces Results Of Phase 3 Study Of LODOTRA&reg; Demonstrate 12-Month Sustained Efficacy And Safety In Rheumatoid Arthritis
Horizon Pharma, Inc. announced today the results from the extended open label portion of The Circadian Administration of Prednisone in Rheumatoid Arthritis-1 (CAPRA-1) Phase 3 European registration study of LODOTRA, a programmed release formulation of low-dose prednisone, which showed sustained improvement in reducing the duration of morning stiffness in patients with Rheumatoid Arthritis (RA) over a 12 month period. (Source: Pharmaceutical Online News)
Inflammatory myofibroblastic tumor of bone: two cases occurring in long bone
We present two examples of IMT arising in a long bone: one in the humerus and one in the femur. In both cases, imaging shows a poorly delineated osteolytic lesion with cortical bone destruction that aggressively extends into surrounding soft tissue. Histologically, the lesion is dominated by differentiated spindle cells with aprominent collagenous stroma and an inflammatory component including plasma cells and lymphocytes, and with positive immunoreactivity for anaplastic lymphoma kinase. The absence of cytologic atypia helps differentiate this lesion from malignant spindle cell tumors. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00256-010-0998-xAuthors Jianyu Chen, The Second Affiliated Hospital, Sun Yat-sen University Department of Radiology 107 Yanjiangxi Rd....
Comparative Effectiveness of Rheumatoid Arthritis Therapies
Abstract&nbsp;&nbsp;Physicians and patients must choose between several therapeutic interventions for rheumatoid arthritis and need to compare the available therapeutic options. Although randomized, placebo-controlled trials are essential to establish the efficacy of a new treatment, they are not much help when it comes to selecting the best therapy for an individual patient. Comparative effectiveness research (CER) is set to provide direct comparisons between therapeutic strategies. CER attempts to weigh the benefits against the potential harms of a particular intervention. Furthermore, CER may help identify specific patient subgroups that are more likely to benefit from a particular therapy or at increased risk of adverse events. Several study designs are available for CER, includi...
Arboviral Encephalitides: Transmission, Emergence, and Pathogenesis
Abstract&nbsp;&nbsp;Arthropod-borne viruses (arboviruses) are of paramount concern as a group of pathogens at the forefront of emerging and re-emerging diseases. Although some arboviral infections are asymptomatic or present with a mild influenza-like illness, many are important human and veterinary pathogens causing serious illness ranging from rash and arthritis to encephalitis and hemorrhagic fever. Here, we discuss arboviruses from diverse families (Flaviviruses, Alphaviruses, and the Bunyaviridae) that are causative agents of encephalitis in humans. An understanding of the natural history of these infections as well as shared mechanisms of neuroinvasion and neurovirulence is critical to control the spread of these viruses and for the development of effective vaccines and treatmen...<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Candidal arthritis in revision knee arthroplasty successfully treated with sequential parenteral-oral fluconazole and amphotericin B-loaded cement spacer
We present a case of a patient with preoperative cutaneous candidiasis, who developed candidal infection during stage revision knee arthroplasty. The patient received intravenous fluconazole for 6&nbsp;weeks and resection arthroplasty with an amphotericin B-loaded cement spacer and continuous oral fluconazole therapy for 9&nbsp;weeks. Revision surgery was successful. Content Type Journal ArticleCategory KneeDOI 10.1007/s00167-010-1211-4Authors Meng-Huang Wu, Chang Gung Memorial Hospital at Chiayi Department of Orthopedic Surgery Chiayi TaiwanKuo-Yao Hsu, Chang Gung Memorial Hospital at Linkou Department of Orthopedic Surgery 5th, Fu-Hsin St. Kweishan, Taoyuan 333 Taiwan, ROC Journal Knee Surgery, Sports Traumatology, ArthroscopyOnline ISSN 1433-7347Print ISSN 0942-2056 (Sou...
Travel Medicine: Healthcare When Traveling Abroad
Title: Travel Medicine: Healthcare When Traveling AbroadCategory: Doctor's ViewsCreated: 3/31/2006Last Editorial Review: 7/23/2010 (Source: MedicineNet Arthritis General)
Insurance Woes Can Add to Burden of Psoriasis
Title: Insurance Woes Can Add to Burden of PsoriasisCategory: Health NewsCreated: 7/22/2010 2:10:00 PMLast Editorial Review: 7/23/2010 (Source: MedicineNet Arthritis General)
Evaluation of telomerase expression in chronic periodontitis
Conclusion : Various mechanisms have been explained to account for telomerase elevation in chronic periodontitis .This study helps us understand the role of telomerase in the pathogenesis of periodontal disease. It could be concluded that telomerase could be used as a marker to assess the severity of inflammation in chronic periodontitis. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Diagnostic 'guidelines' a barrier to prompt relief for some back pain
(Johns Hopkins Medical Institutions) Slavishly following long-held guidelines for diagnosing the cause of arthritis-related back pain is resulting in excessive tests, delays in pain relief and wasteful spending of as much as $10,000 per patient, new Johns Hopkins-led research suggests. (Source: EurekAlert! - Medicine and Health)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Juvenile Rheumatoid Arthritis Awareness Month
July is juvenile rheumatoid arthritis awareness month. Learn more on the MedlinePlus juvenile rheumatoid arthritis topic page. (Source: What's New on MedlinePlus)
High BMI in late teens linked to increased psoriatic arthritis risk
People with psoriasis who are obese in their late teenage years are at increased risk for developing psoriatic arthritis later in life, researchers report. (Source: MedWire News - Dermatology)
Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity
Activation of the alpha7 receptor ([alpha]7nAChR) has been shown to be important in inflammation and immune regulation, and is also essential in the neural cholinergic anti-inflammatory pathway. The aim of this study was to investigate the role of [alpha]7nAChR in the development of experimental arthritis and immune activation. Mice lacking the [alpha]7nAChR were immunized with collagen II and the development of arthritis was assessed. Another group of [alpha]7nAChR-deficient mice was immunized with ovalbumin, spleen and lymph node cells were isolated and the proliferative responses to restimulation with ovalbumin or concanavalin A were investigated. We could demonstrate significantly milder arthritis and less cartilage destruction, together with a decrease of T cell content in lymph nodes...
Hylan G-F 20 versus methylprednisolone for hip osteoarthritis
Source: BioSpace Area: News According to the results of a prospective, double-blind study, intra-articular hylan G-F 20 was comparable to intra-articular methylprednisolone acetate (MPA) at improving pain and function in patients with hip osteoarthritis (OA).&nbsp; &nbsp; The study included 313 patients with symptomatic Kellgren-Lawrence grade (KLG) 2 or 3 hip OA, who were randomised to receive either two injections of hylan G-F 20 two weeks apart (n=150) or one injection of 40mg MPA followed by a sham injection two weeks later (n=155).&nbsp; Response was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) domain A - at week 26 this improved by 16.6 mm for hylan G-F 20 versus 13.6 mm for MPA.&nbsp; Response rates were higher with hylan G-F 20 versus MP...
Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus
Conclusions: Percentages IL-17 expressing T-cells correlate with disease activity. Further, these cells show increased expression of costimulatory markers such as CD134 and CD80. The presence of CD134+ T-cells in renal biopsies of lupus nephritis patients suggest that these cells migrate to the kidney and might contribute to inflammatory processes through IL-17 secretion. (Source: Arthritis Research and Therapy)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Bcl-xL affects the development of functional CD4 regulatory T cells
None (letter) (Source: Arthritis Research and Therapy)
Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.
Authors: Westman M, Saha S, Morshed M, Lampa J Summary Activation of the alpha7 receptor (alpha7nAChR) has been shown to be important in inflammation and immune regulation, and is also essential in the neural cholinergic anti-inflammatory pathway. The aim of this study was to investigate the role of alpha7nAChR in the development of experimental arthritis and immune activation. Mice lacking the alpha7nAChR were immunized with collagen II and the development of arthritis was assessed. Another group of alpha7nAChR-deficient mice was immunized with ovalbumin, spleen and lymph node cells were isolated and the proliferative responses to restimulation with ovalbumin or concanavalin A were investigated. We could demonstrate significantly milder arthritis and less cartilage destruction, togeth...
Black Cohosh
This fact sheet provides basic information about the herb black cohosh&#8212;common names, uses, potential side effects, and resources for more information. Black cohosh, a member of the buttercup family, is a plant native to North America. It was used in Native American medicine and was a home remedy in 19th-century America.What Black Cohosh Is Used ForBlack cohosh has a history of use for rheumatism (arthritis and muscle pain) but has been used more recently to treat hot flashes, night sweats, vaginal dryness, and other symptoms that can occur during menopause.Black cohosh has also been used for menstrual irregularities and premenstrual syndrome, and to induce labor. (Source: NCCAM Featured Content)
Clinical Trials Update: July 22, 2010
Rheumatoid Arthritis Pediatric Migraine Type 2 Diabetes (Source: The Doctors Lounge - Health News)
Stone Research Foundation Study Reveals Biologic Joint Repair May Delay Or Prevent The Need For Artificial Knee Joint Replacement
The Stone Research Foundation released findings of the longest and largest study of its kind on biologic knee joint repair. The study is published in July's issue of The British Journal of Bone & Joint Surgery. Study findings indicate that arthritic patients can forestall, or in some cases, avoid, total knee replacement with artificial joints by opting for meniscal allograft transplantations performed concurrently with articular cartilage repair. The techniques replace worn meniscus with donated tissue and use the patient's own stem cells for repair... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
PsoriasisDX Genetic Test For Psoriatic Arthritis Now Available In Europe As A CE Marked In Vitro Diagnostic Medical Device
Molecular dermatology research and development innovator DermaGenoma, Inc. today announced that the PsoriasisDX Genetic Test for Psoriatic Arthritis (PsA) is now available as a CE Marked product under the European In Vitro Diagnostic Directive. CE Marking is required for certain product groups to indicate conformity with the essential requirements set out in European Directives. The PsoriasisDX Genetic Test for Psoriatic Arthritis complies with the essential requirements of the European IVD Directive... (Source: Health News from Medical News Today)
Congestive Heart Failure
Title: Congestive Heart FailureCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 7/22/2010 (Source: MedicineNet Arthritis General)
Childhood psoriasis
Sunil Dogra, Inderjeet KaurIndian Journal of Dermatology, Venereology, and Leprology 2010 76(4):357-365Psoriasis is a common dermatosis in children with about one third of all patients having onset of disease in the first or second decade of life. A chronic disfiguring skin disease, such as psoriasis, in childhood is likely to have profound emotional and psychological effects, and hence requires special attention. Psoriasis in children has been reported to differ from that among adults being more frequently pruritic; plaque lesions are relatively thinner, softer, and less scaly; face and flexural involvement is common and guttate type is the characteristic presentation. Whether onset in childhood predicts a more severe form of psoriasis is a matter of controversy, it may cause significant ...
Tophi as first manifestation of gout
Sankha Koley, Atul Salodkar, Sanjiv Choudhary, Arvind Bhake, Kailash Singhania, Manoj ChoudhuryIndian Journal of Dermatology, Venereology, and Leprology 2010 76(4):393-396Chronic tophaceous gout classically occurs after 10 years or more of recurrent polyarticular gout. However, tophi can also occur as first sign of the disorder. Here we report a 20-year-old male presenting with multiple subcutaneous nodules on bilateral feet and toes, left palm, right elbow, helix of left ear since last one and half year prior to any other manifestation of gout. He was having mild intermittent arthritis since last six months. Fine Needle Aspiration Cytology of one tophus showed monosodium urate crystals, which are pathognomonic for gout. His serum uric acid was normal and ultrasound revealed bilateral neph...
First-line DMARD Choice in Early Rheumatoid Arthritis - Do Prognostic Factors Play a Role?
What are the best treatment choices for patients with early rheumatoid arthritis? Rheumatology (Source: Medscape Rheumatology Headlines)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
Conclusions: Significant changes occur in the BM niche with the establishment and progression of RA-like disease. Those changes may be responsible for aspects of the disease, including advance of osteoporosis. An understanding of the molecular mechanisms leading to those changes may lead to new strategies for therapeutic intervention. (Source: Arthritis Research and Therapy)
[Stress and rheumatoid arthritis.]
Authors: Malysheva O, Pierer M, Wagner U, Baerwald CG Rheumatoid arthritis (RA) is a chronic rheumatic disease of unknown aetiology and variable severity. It is now well known that several risk factors are involved in its pathogenesis, including genetic factors and sex hormones as well as environmental factors, i.e. infections and stress. In particular stress is now recognised as an important risk factor for the onset and even more for the modulation of disease activity in RA. Many studies have clearly shown that chronic mild stress (family or professional stress) may lead to proinflammatory effects, increasing disease activity. Furthermore, a positive correlation between the stress level at the onset of RA and radiological progression could be demonstrated. The onset of RA was associa...
Predictive factors of response to rituximab therapy in rheumatoid arthritis: What do we know today?
Authors: Benucci M, Manfredi M, Puttini PS, Atzeni F Interest in the role of B cells in the pathogenesis of rheumatoid arthritis (RA) has increased over recent years. Rituximab (RTX), a chimeric monoclonal antibody specific for human CD20 targeting B lymphocytes, has been used to treat RA patients, and its efficacy has been clearly demonstrated in controlled clinical trials and open-label observational studies. However, it is still not known which sub-group(s) of patients will respond to RTX therapy or whether there are any factors predicting a response. The aim of this review is to discuss the most important predictive factors that are so far known. It is known that the clinical response to RTX therapy is associated with lower interferons (IFN-gamma) and B-cell activating factor (BAFF...
Health Tip: Signs That You May Have Hand Arthritis
Here are some common symptoms (Source: The Doctors Lounge - Health News)
Health Tip: Signs That You May Have Hand Arthritis
Here are some common symptomsSource: HealthDay Related MedlinePlus Pages: Arthritis, Hand Injuries and Disorders (Source: MedlinePlus Health News)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis
Conclusions ICOS costimulation is not mandatory for the differentiation of Th1 or Th17 cells. Instead, the lack of ICOS costimulation results in reduced survival of G6PI-specific Th cells irrespective of their functional differentiation. This study demonstrates that a thorough examination of the quantity and the quality of antigen-specific immune responses is useful to determine ex vivo correlates of efficacy for immunomodulating treatments. (Source: Annals of the Rheumatic Diseases)
Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis
Conclusions Tregs control the transition from acute self-limiting to non-remitting destructive G6PI-induced arthritis already in the preclinical disease stage. Once established, non-remitting destructive arthritis is not controlled by restoration of normal Treg numbers. These findings question the rationale of therapeutic approaches augmenting Treg number or function in established arthritis. (Source: Annals of the Rheumatic Diseases)
The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity
Conclusion In vivo Treg expansion is a feasible and effective approach in the treatment of autoimmune diseases. (Source: Annals of the Rheumatic Diseases)
Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells
Conclusions Rabeximod suppresses arthritis by preventing activation of inflammatory cells, most likely macrophages, in a time dependent fashion, downstream of TLR2 and TLR4 stimulation. (Source: Annals of the Rheumatic Diseases)
Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
Conclusions In a large European RA cohort further evidence for the association of 18 markers with RA development has been obtained. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis
Conclusion Epitope spreading with an increase in the recognition of citrullinated antigens occurs before the onset of RA. Immunological differences in ACPA fine specificity between UA&ndash;UA patients and UA&ndash;RA patients are present at baseline and are associated with the future disease course. (Source: Annals of the Rheumatic Diseases)
Role of IL-17 in the Th1 systemic defects in rheumatoid arthritis through selective IL-12R{beta}2 inhibition
Conclusion In RA, IL-12 hyporesponsiveness is associated with IL-17R-mediated downregulation of IL-12R&beta;2 expression. IL-17 may reinforce Th17 lineage commitment and proinflammatory and destructive effects through Th1 inhibition and positive feedback effects in RA synovial cells. Anti-inflammatory effects of IL-17/IL-17R antagonism may include the restoration of protective Th1 responses. (Source: Annals of the Rheumatic Diseases)
HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis
(Source: Annals of the Rheumatic Diseases)
Impact of anti-tumour necrosis factor therapy on the weight of patients with rheumatoid arthritis
(Source: Annals of the Rheumatic Diseases)
Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population
(Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
From bone biology to clinical outcome: state of the art and future perspectives
In the last decade progress has been made in our understanding of bone biology. In particular, the relation between inflammation and bone has become much clearer, leading to bone-targeting therapies in inflammatory rheumatic diseases. The clinical sequelae of the influences of both inflammation and immobility (due to arthritis) on bone for different rheumatic diseases (such as rheumatoid arthritis, systemic lupus erythematosus and spondyloarthritides) have also now captured the attention of clinicians. In the last decade the well-known negative influences of glucocorticoids on bone have become more treatable as a result of new drugs that stimulate osteoblasts and restore the negative bone balance. (Source: Annals of the Rheumatic Diseases)
Application of the DAREA/DAPSA score for assessment of disease activity in psoriatic arthritis
Conclusion The analyses of this study provide evidence of the utility and validity of the DAREA for PsA disease activity assessment. A second name should therefore be assigned to this score: DAPSA (for &lsquo;Disease Activity index for PSoriatic Arthritis&rsquo;). (Source: Annals of the Rheumatic Diseases)
Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
Conclusions Over 2 years, no treatment achieved a clinically important difference in WOMAC pain or function as compared with placebo. However, glucosamine and celecoxib showed beneficial but not significant trends. Adverse reactions were similar among treatment groups and serious adverse events were rare for all treatments. (Source: Annals of the Rheumatic Diseases)
Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis
Conclusion Spinal mobility impairment in AS is independently determined both by irreversible spinal damage and by reversible spinal inflammation. Spinal mobility impairment is more influenced by spinal inflammation in early disease, and by structural damage in later disease. (Source: Annals of the Rheumatic Diseases)
A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis
Conclusion This is the first report of a CLEC16A association with JIA and a split of the RA association according to anti-CCP status. Different causative variants underlie the rheumatic versus the organ specific diseases. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial
Conclusion The subgroup of patients with longer disease duration, ANA negativity, higher disability and presence of wrist activity were significantly associated with a poorer response to a 6-month MTX course. (Source: Annals of the Rheumatic Diseases)
Exploring The Possibility That Adult Stem Cells Could Help Heal Joints
Bioengineers from Rice University's BioScience Research Collaborative have won a $1.7 million grant from the National Institutes of Health to develop an injectable mix of polymers and adult stem cells that can spur the growth of new cartilage in injured knees and other joints. "Millions of people live with pain, limited mobility and arthritis that often result from cartilage injuries, particularly those to the knee," said Rice researcher Kurt Kasper, a principal investigator on the new five-year grant... (Source: Health News from Medical News Today)
Health Tip: Signs That You May Have Hand Arthritis
Title: Health Tip: Signs That You May Have Hand ArthritisCategory: Health NewsCreated: 7/21/2010 8:10:00 AMLast Editorial Review: 7/21/2010 (Source: MedicineNet Chronic Pain General)
Health Tip: Signs That You May Have Hand Arthritis
Title: Health Tip: Signs That You May Have Hand ArthritisCategory: Health NewsCreated: 7/21/2010 8:10:00 AMLast Editorial Review: 7/21/2010 (Source: MedicineNet Senior Health General)
'Get Moving' Can Be Vital Advice for Seniors
Title: 'Get Moving' Can Be Vital Advice for SeniorsCategory: Health NewsCreated: 7/20/2010 4:10:00 PMLast Editorial Review: 7/21/2010 (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Health Tip: Signs That You May Have Hand Arthritis
Title: Health Tip: Signs That You May Have Hand ArthritisCategory: Health NewsCreated: 7/21/2010 8:10:00 AMLast Editorial Review: 7/21/2010 (Source: MedicineNet Arthritis General)
AJC Editor's Consensus: Rheumatoid Arthritis and Atherosclerotic Cardiovascular Disease
This continuing medical education activity is supported by an educational grant from Amgen, Thousand Oaks, California. Dr. Friedewald has received speaker's honoraria from Novartis, Bridgewater, New Jersey. Dr. Friedewald is a consultant for AstraZeneca, Wilmington, Delaware; and NiCox, Warren Township, New Jersey. Dr. Ganz has received speaker's honoraria from Pfizer, New York, New York. Dr. Kremer has received speaker's honoraria from Amgen; Bristol-Myers Squibb, New York, New York; and Wyeth, Madison, Wisconsin. Dr. Mease has received research grants (investigator), consulting fees, and speaker's honoraria from Abbott Laboratories, Abbott Park, Illinois; Amgen; Biogen Idec, Cambridge, Massachusetts; Bristol-Myers Squibb; Centocor, Horsham, Pennsylvania; Genentech, South San Francisco, ...
Obesity in Young Adults May Predict Later PsA (CME/CE)
Obesity in early adulthood is an independent risk factor for the development of psoriatic arthritis, a large case series found. (Source: MedPage Today Dermatology)
Obesity in early adulthood associated with increased risk of psoriatic arthritis
Among persons with psoriasis, those who reported being obese at age 18 had an increased risk of developing psoriatic arthritis, according to a report in the July 19 issue of Archives of Dermatology, one of the JAMA/Archives journals. (Source: ScienceDaily Headlines)
Diagnostic value of anti-modified citrullinated vimentin in rheumatoid arthritis
Conclusion: Anti-CCP antibodies have higher diagnostic specificity and positive predictive value than RF and anti-MCV antibodies. RF has the highest sensitivity when compared to anti-CCP and anti-MCV antibodies. Thus anti-MCV antibody is not a better marker when compared to RF or anti-MCV antibody in the diagnosis of RA patients. (Source: APLAR Journal of Rheumatology)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Significant differences between the Borrelia-infection and Borrelia-vaccination and -infection models of Lyme arthritis in C3H/HeN mice
The immunological events leading to the development of Lyme arthritis in humans are partially understood. Much of this information has been gained by studying the course of infection of naïve or vaccinated mice with Borrelia burgdorferi. However, the Borrelia-vaccination and -infection model has not been described using the organismal parameters commonly used in the widely accepted Borrelia-infection model. This is the first comparison between the Borrelia-infection and the Borrelia-vaccination and -infection models of arthritis. Borrelia-vaccinated and -infected C3H/HeN mice develop acute inflammation comparable to that of nonvaccinated, Borrelia-infected C3H/HeN mice. The duration and severity of arthritis in Borrelia-vaccinated and -infected mice was slightly increased compared with Bo...
Study: Obesity Predicts Psoriatic Arthritis
Body mass index at age 18 helps determine who may develop psoriatic arthritis later in adulthood, researchers say. WebMD Health News (Source: Medscape Today Headlines)
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis [Immunology]
Osteoclasts are bone-eroding cells that develop from monocytic precursor cells in the presence of receptor activator of NF-B ligand (RANKL)... (Source: Proceedings of the National Academy of Sciences)
Older people with HIV face multiple disadvantages, study finds
This report clearly shows that the problems many of us face in later life, such as financial pressures, deteriorating health and isolation are all exacerbated by the impact of HIV on people?s lives. Now people are living far longer with HIV than ever before, we need to shift the focus on support services to improving quality of life. To achieve this, it is vital that we increase awareness and understanding of the needs of this group across a range of health, social care, housing and advice services.?The full ?50 Plus? report will be available from October 2010 on The Joseph Rowntree Foundation website and both Terrence Higgins Trust and Age UK will be using the findings to inform future service development.EndsNotes to Editors'50 Plus? research was conducted through an online and...
Protecting Knees Now Might Prevent Pain Later
Taking a few small steps toward protecting your knees when you are younger might help you avoid debilitating problems when you get older. Studies have shown that nearly half of adults will get knee arthritis in at least one knee by age 85. For obese people, the risk is even greater. "Every time you take a step you apply three times your body weight to the knee," said Dr. William J. Bryan, an orthopedic surgeon with the Methodist Center for Sports Medicine in Houston. "When you run it's five times, when you jump it's seven times... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Study: Obesity Predicts Psoriatic Arthritis
Title: Study: Obesity Predicts Psoriatic ArthritisCategory: Health NewsCreated: 7/20/2010 11:03:00 AMLast Editorial Review: 7/20/2010 11:03:38 AM (Source: MedicineNet Chronic Pain General)
Study: Obesity Predicts Psoriatic Arthritis
Title: Study: Obesity Predicts Psoriatic ArthritisCategory: Health NewsCreated: 7/20/2010 11:03:00 AMLast Editorial Review: 7/20/2010 11:03:38 AM (Source: MedicineNet Skin General)
Study: Obesity Predicts Psoriatic Arthritis
Title: Study: Obesity Predicts Psoriatic ArthritisCategory: Health NewsCreated: 7/20/2010 11:03:00 AMLast Editorial Review: 7/20/2010 11:03:38 AM (Source: MedicineNet Senior Health General)
Obesity Predicts Psoriatic Arthritis
Study: Obesity Predicts Psoriatic Arthritis (Source: eMedicineHealth.com)
Study: Obesity Predicts Psoriatic Arthritis
Title: Study: Obesity Predicts Psoriatic ArthritisCategory: Health NewsCreated: 7/20/2010 11:03:00 AMLast Editorial Review: 7/20/2010 11:03:38 AM (Source: MedicineNet Arthritis General)<div id="medworm"><p><b><i>MedWorm Message:</i></b> Register for <b><a href="http://www.medmatcha.com" target ="_self">MedMatcha, MedWorm's medical advertising network</a></b>, and receive $5 free advertising.</p></div>
Marfan Syndrome
Title: Marfan SyndromeCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 7/20/2010 (Source: MedicineNet Arthritis General)
Arthritis detection tool developed
A device allowing doctors and nurses to test for and monitor osteoarthritis has been developed by scientists at Lancaster University (Source: Nursing in Practice)
Tai Chi for Arthritis Relief
Gentle movements of the ancient Chinese exercise tai chi are one of many alternatives to help elderly people find pain relief. (Source: WebMD Health)
ARTHRITIS (Arnica Montana, Bryonia, Hypericum Perforatum) Liquid [Apotheca Company]
Updated Date: Jul 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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